Results 71 to 80 of about 30,590 (168)
Verotoxin A Subunit Protects Lymphocytes and T Cell Lines against X4 HIV Infection in Vitro
Toxins, 2012 Our previous genetic, pharmacological and analogue protection studies identified the glycosphingolipid, Gb3 (globotriaosylceramide, Pk blood group antigen) as a natural resistance factor for HIV infection. Gb3 is a B cell marker (CD77), but a fraction of
Pei Lin Shi +8 more
doaj +1 more source
Gb3-binding lectins as potential carriers for transcellular drug delivery
Expert Opinion on Drug Delivery, 2016 Objectives: Epithelial cell layers as well as endothelia forming the blood-brain barrier can drastically reduce the efficiency of drug targeting. Our goal was to investigate lectins recognizing the glycosphingolipid globotriaosylceramide (Gb3) for their potential as carriers for transcytotic drug delivery.
Stefan K. Müller +8 more
openaire +4 more sources
Journal of Lipid Research, 1992 The activity of alpha-galactosyltransferase in cultured rat pheochromocytoma subcloned (PC12h) cells was examined using Gb3 as the acceptor for the galactose from UDP-galactose.
S Pal, M Saito, T Ariga, RK Yu
doaj +1 more source
Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Advanced ScienceCutaneous fibroblast heterogeneity is mechanistically linked to wound repair outcomes and fibrotic progression, with glycosphingolipid metabolism emerging as a critical determinant of physiological fibroblast diversity.
Sujie Xie +13 more
doaj +1 more source
In vitro effect of globotriaosylceramide on electron transport chain complexes and redox parameters
Anais da Academia Brasileira de Ciências: Fabry disease (FD) is an X-linked inherited disease and occurs due to mutations in GLA gene that encodes the α-galactosidase enzyme. Consequently, there is an accumulation of enzyme substrates, namely globotriaosylceramide (GB3).
RAFAELA M. ALVARIZ +4 more
doaj +1 more source
γ2 Chain of Laminin-5 Is Recognized By Monoclonal Antibody GB3
Journal of Investigative Dermatology, 1995 Herlitz junctional epidermolysis bullosa is an autosomal recessive disorder characterized by generalized blistering at the lamina lucida of the cutaneous basement membrane. The monoclonal antibody GB3 has been used as a diagnostic probe because of its lack of reactivity in patient skin.
Matsui, Chihiro +5 more
openaire +2 more sources
Glykosphingolipide Gb3 und iGb3 [PDF]
Der Pathologe, 2008 S. Porubsky +6 more
openaire +1 more source
Case Reports in Nephrology, 2019 Renal involvement is associated with a greater morbidity and mortality in Fabry disease. Pathological albuminuria, the first Fabry nephropathy clinical manifestation, can occur from early childhood, although histological lesions such as tubulo ...
Sebastián Jaurretche +2 more
doaj +1 more source
Fabry disease in the haemodialysis population: outcome of a UK screening study (SoFAH)
BMC NephrologyBackground and hypothesis Fabry disease (FD) is an X-linked inherited disorder with an estimated prevalence among the end-stage kidney disease (ESKD) population of 0.3% in men and 0.1% in women [1].
K.P. Ng +13 more
doaj +1 more source