Results 51 to 60 of about 12,121 (216)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
NGC 6139: a normal massive globular cluster, or a first-generation dominated cluster? Clues from the light elements [PDF]
Astronomy & Astrophysics, 2015 Accepted for publication on A& ...
Bragaglia, A. +7 more
openaire +4 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
DETECTION OF A SECOND-GENERATION BINARY IN THE GLOBULAR CLUSTER ω CENTAURI
The Astrophysical Journal, 2012 omega Centauri is the largest globular cluster in the Milky Way; it is composed of multiple stellar populations. Photometric solutions for the EA-type eclipsing binary NV364 in this cluster indicate that NV364 is a well-detached binary and that both of its components are early-type normal main-sequence stars.
Kai Li, S.-B. Qian, K.-C. Leung
openaire +1 more source
An aluminium tool for multiple stellar generations in the globular clusters 47 Tucanae and M 4 [PDF]
Astronomy & Astrophysics, 2013 11 pages, 9 figures, 2 on-line tables: accepted for publication on Astronomy and ...
Carretta, Eugenio +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Globular cluster abundances: the imprint of first-generation massive stars [PDF]
Proceedings of the International Astronomical Union, 2009 AbstractGalactic globular cluster (GC) stars exhibit abundance patterns that are not shared by their field counterparts, namely the well-documented O–Na, C–N and Mg–Al anticorrelations. Recent observations provide compelling evidence that these abundance anomalies were already present in the intracluster gas from which the presently observed stars ...
openaire +1 more source
Diluting the material forming the second generation stars in globular clusters: the contribution by unevolved stars [PDF]
Astronomy and Astrophysics, 2010 Accepted for publication on Astronomy and ...
Gratton, Raffaele G., Carretta, Eugenio
openaire +2 more sources
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source