Results 61 to 70 of about 12,121 (216)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Evolution of the disky second generation of stars in globular clusters on cosmological timescales

Astronomy & Astrophysics
Context. Many Milky Way globular clusters (GCs) host multiple stellar populations, challenging the traditional view that GCs are single-population systems. It has been suggested that second-generation stars could form in a disk from gas lost by first-generation stars or from external accreted gas.
Peter Berczik, Taras Panamarev, Maryna Ishchenko, Bence Kocsis   +3 more
openaire   +2 more sources

Helium in first and second-generation stars in globular clusters from spectroscopy of red giants [PDF]

Astronomy and Astrophysics, 2010
In press on A& ...
Bragaglia, A., Carretta, E., Gratton, R., D'Orazi, V., Cassisi, S., Lucatello, S.   +5 more
openaire   +4 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

The influence of magnetic fields on second-generation star formation in globular clusters

Monthly Notices of the Royal Astronomical Society
ABSTRACT We investigate the previously unexplored role of magnetic fields in the formation of second-generation (SG) stars in proto-globular clusters (GCs) using 3D radiation-magnetohydrodynamical simulations. This study is based on the asymptotic giant branch (AGB) scenario and incorporates photoionization feedback and stellar winds ...
Yaghoobi, A, Tabatabaei, F, Rosdahl, Joakim, Commercon, B, Sheikhnezami, S, Calura, F   +5 more
openaire   +2 more sources

The Next Generation Virgo Cluster Survey (NGVS). XXVI. The Issues of Photometric Age and Metallicity Estimates for Globular Clusters [PDF]

The Astrophysical Journal, 2017
Abstract Large samples of globular clusters (GC) with precise multi-wavelength photometry are becoming increasingly available and can be used to constrain the formation history of galaxies. We present the results of an analysis of Milky Way (MW) and Virgo core GCs based on 5 optical-near-infrared colors and 10 synthetic stellar ...
Mathieu Powalka, Ariane Lançon, Thomas H. Puzia, Eric W. Peng, Chengze Liu, Roberto P. Muñoz, John P. Blakeslee, Patrick Côté, Laura Ferrarese, Joel Roediger, Rúben Sánchez-Janssen, Hongxin Zhang, Patrick R. Durrell, Jean-Charles Cuillandre, Pierre-Alain Duc, Puragra Guhathakurta, S. D. J. Gwyn, Patrick Hudelot, Simona Mei, Elisa Toloba   +19 more
openaire   +4 more sources

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source