Results 41 to 50 of about 12,121 (216)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Gravitational Waves Generated by Globular Cluster Systems Collapse

, 1997
According to the hypothesis that AGNs are massive black holes and the mass which feeds them is made of stars belonging to globular clusters frictionally decayed and tidally destroyed by the field of the central object, it is possible to give an estimate of the number and spectral characteristics of detectable gravitational wave impulses generated by ...
CAPUZZO DOLCETTA, Roberto Angelo, MIOCCHI, PAOLO   +1 more
openaire   +3 more sources

The Next Generation Virgo Cluster Survey. XVII. A Search for Planetary Nebulae in Virgo Cluster Globular Clusters [PDF]

The Astrophysical Journal, 2019
Abstract The occurrence of planetary nebulae (PNe) in globular clusters (GCs) provides an excellent chance to study low-mass stellar evolution in a special (low-metallicity, high stellar density) environment. We report a systematic spectroscopic survey for the [O iii] 5007 Å emission line of PNe in 1469 Virgo GCs and 121 Virgo ultra ...
Weijia Sun, Eric W. Peng, Youkyung Ko, Patrick Côté, Laura Ferrarese, Myung Gyoon Lee, Chengze Liu, Alessia Longobardi, Igor V. Chilingarian, Chelsea Spengler, Ann I. Zabludoff, Hong-Xin Zhang, Jean-Charles Cuillandre, Stephen D. J. Gwyn   +13 more
openaire   +4 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

DISCOVERY OF A METAL-POOR FIELD GIANT WITH A GLOBULAR CLUSTER SECOND-GENERATION ABUNDANCE PATTERN [PDF]

The Astrophysical Journal, 2016
ABSTRACT We report on the detection, from observations obtained with the Apache Point Observatory Galactic Evolution Experiment spectroscopic survey, of a metal-poor ([Fe/H] = −1.3 dex) field giant star with an extreme Mg–Al abundance ratio ([Mg/Fe] = −0.31 dex; [Al/Fe] = 1.49 dex).
Fernández-Trincado, J., Robin, A., Moreno, E., Schiavon, R., García Pérez, A.E., Vieira, K., Cunha, K., Zamora, O., Sneden, C., Souto, Diogo, Carrera, R., Johnson, J., Shetrone, M., Zasowski, G., García-Hernández, D., Majewski, S., Reylé, C., Blanco-Cuaresma, S., Martinez-Medina, L., Pérez-Villegas, A., Valenzuela, O., Pichardo, B., Meza, A., Mészáros, Sz., Sobeck, J., Geisler, D., Anders, F., Schultheis, M., Tang, B., Roman-Lopes, A., Mennickent, R., Pan, K., Nitschelm, C., Allard, F.   +33 more
openaire   +5 more sources

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

The merger of hard binaries in globular clusters as the primary channel for the formation of second-generation stars

Monthly Notices of the Royal Astronomical Society, 2023
ABSTRACT We have recently presented observational evidence which suggests that the origin of the second-generation (G2) stars in globular clusters (GCs) is due to the binary-mediated collision of primordial (G1) low-mass main-sequence (MS) stars. This mechanism avoids both the mass budget problem and the need of external gas for dilution.
Valery Kravtsov, Sami Dib, Francisco A Calderón   +2 more
openaire   +2 more sources