Results 111 to 120 of about 86,301 (339)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Is Earendel a Star Cluster?: Metal-poor Globular Cluster Progenitors at z ∼ 6

The Astrophysical Journal Letters
The strongly lensed z  ∼ 6 Sunrise galaxy offers an incredible opportunity to investigate star formation in the early Universe on parsec or smaller scales.
Massimo Pascale, Liang Dai, Brenda L. Frye, Aliza G. Beverage   +3 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Globular Cluster Counts around 700 Nearby Galaxies

The Astrophysical Journal
Empirically, the total number (or total mass) of globular clusters (GCs) bound in a single galactic system correlates with the virial mass of the system. The form of this relation and its intrinsic scatter are potentially valuable constraints on theories
Minh Ngoc Le, Andrew P. Cooper
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

The inner Galactic globular clusters

EPJ Web of Conferences, 2013
Galactic globular clusters located towards the inner regions of the Milky Way have been historically neglected, mainly due to the difficulties caused by the presence of an elevated extinction by foreground dust, and high field star densities along the ...
Mateo M., Catelan M., Alonso-García J., Minniti D.   +3 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Another Faint UV Object Associated with a Globular Cluster X-Ray Source: The Case of M92

, 2000
The core of the metal poor Galactic Globular Cluster M92 (NGC 6341) has been observed with WFPC2 on the Hubble Space Telescope through visual, blue and mid-UV filters in a program devoted to study the evolved stellar population in a selected sample of ...
Barbara Paltrinieri, Buonanno R., Cool A. M., Ferraro F. R., Flavio Fusi Pecci, Fox D., Francesco R. Ferraro, Hakala P. J., Hasinger G., Johnston H. M., Naylor T., Oosterhoff P. T., Richer H. B., Robert T. Rood, Roberto Buonanno, Verbunt F., Verbunt F., Verbunt F., Warner B.   +18 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Searching for Pulsars in Globular Clusters with the Fast-folding Algorithm and a New Pulsar Discovered in M13

The Astrophysical Journal
We employed the fast-folding algorithm on L -band globular cluster (GC) observations taken with the Five-hundred-meter Aperture Spherical radio Telescope to search for new pulsars, especially those with a long rotational period.
Yaowei Li, Lin Wang, Lei Qian, Liyun Zhang, Yujie Chen, Dejiang Yin, Baoda Li, Yinfeng Dai, Ralph P. Eatough, Wenze Li, Dongyue Jiang, Xingnan Zhang, Minghui Li, Yujie Lian, Yuxiao Wu, Tong Liu, Kuo Liu, Zhichen Pan   +17 more
doaj   +1 more source