Results 131 to 140 of about 87,149 (376)

Utilizing Voronoi Tessellations to Determine Radial Density Profiles

open access: yesThe Astronomical Journal
We have developed a novel method of determining 2D radial density profiles for astronomical systems of discrete objects using Voronoi tessellations. This Voronoi-based method was tested against the standard annulus-based method on five simulated systems ...
Veronika Dornan, William E. Harris
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Energy distribution in globular star clusters [PDF]

open access: yesSymposium - International Astronomical Union, 1964
The present investigation is concerned with the energy distributions in globular clusters. In a sense, energy-distribution measurements are comparable with multi-colour photometry. The chief advantage is that narrower band-passes may be used and the entire spectrum traced, whereas in multi-colour photometry one is limited to effective wavelengths ...
L. H. Aller, D. J. Faulkner
openaire   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Globular Cluster Formation in M82

open access: yes, 2003
We present high resolution mid-infrared (mid-IR; 11.7 and 17.65 micron) maps of the central 400 pc region of the starburst galaxy M82. Seven star forming clusters are identified which together provide ~ 15% of the total mid-IR luminosity of the galaxy ...
Cottrell G.   +6 more
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

FAST Discovery of Eight Isolated Millisecond Pulsars in NGC 6517

open access: yesThe Astrophysical Journal Letters
We present the discovery of eight isolated millisecond pulsars in globular cluster (GC) NGC 6517 using the Five-hundred-meter Aperture Spherical radio Telescope (FAST).
Dejiang Yin   +16 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Is Earendel a Star Cluster?: Metal-poor Globular Cluster Progenitors at z ∼ 6

open access: yesThe Astrophysical Journal Letters
The strongly lensed z  ∼ 6 Sunrise galaxy offers an incredible opportunity to investigate star formation in the early Universe on parsec or smaller scales.
Massimo Pascale   +3 more
doaj   +1 more source

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