Results 151 to 160 of about 87,149 (376)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Searching for Pulsars in Globular Clusters with the Fast-folding Algorithm and a New Pulsar Discovered in M13

The Astrophysical Journal
We employed the fast-folding algorithm on L -band globular cluster (GC) observations taken with the Five-hundred-meter Aperture Spherical radio Telescope to search for new pulsars, especially those with a long rotational period.
Yaowei Li, Lin Wang, Lei Qian, Liyun Zhang, Yujie Chen, Dejiang Yin, Baoda Li, Yinfeng Dai, Ralph P. Eatough, Wenze Li, Dongyue Jiang, Xingnan Zhang, Minghui Li, Yujie Lian, Yuxiao Wu, Tong Liu, Kuo Liu, Zhichen Pan   +17 more
doaj   +1 more source

The inner Galactic globular clusters

EPJ Web of Conferences, 2013
Galactic globular clusters located towards the inner regions of the Milky Way have been historically neglected, mainly due to the difficulties caused by the presence of an elevated extinction by foreground dust, and high field star densities along the ...
Mateo M., Catelan M., Alonso-García J., Minniti D.   +3 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Ancient Relic Moderately Metal-rich Bulge Cluster Tonantzintla 2

The Astrophysical Journal Letters
The assembly history of the Galactic bulge is intimately tied to the formation of the proto–Milky Way, yet reconstructing this early phase is difficult because mergers and secular evolution have erased most of its original structure.
Sergio Ortolani, Stefano O. Souza, Domenico Nardiello, Beatriz Barbuy, Eduardo Bica, Bernardo P.L. Ferreira, Cristina Chiappini, José G. Fernández-Trincado, Heitor Ernandes   +8 more
doaj   +1 more source

A Chemical Abundance Study of One Red Giant Star in NGC 5694: A Globular Cluster with a Dwarf Spheroidal Chemical Signature? [PDF]

, 2006
Jae-Woo Lee, Mercedes López‐Morales, Bruce W. Carney   +2 more
openalex   +1 more source

RR Lyrae Stars in Globular Clusters [PDF]

International Astronomical Union Colloquium, 2000
AbstractOf the several types of variable stars that occur in globular clusters, RR Lyrae stars have deservedly received the most attention. These stars are ideally suited for comparisons between evolution and pulsation theory, they play a prominent role in distance determinations, and are valuable tracers of the oldest stellar populations.
openaire   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Variable stars in the VVV globular clusters

Astronomy & Astrophysics
Context. High reddening near the Galactic plane hampers observations and proper characterization of the globular clusters (GCs) located toward the inner regions of the Milky Way. Aims. The VISTA Variables in the Vía Láctea (VVV) survey observed the Galactic bulge and adjacent disk for several years, providing multi-epoch, near-infrared images for 41 ...
Javier Alonso-García, Leigh C. Smith, Jason L. Sanders, Dante Minniti, Márcio Catelan, Gonzalo Aravena Rojas, Julio A. Carballo-Bello, José G. Fernández-Trincado, Carlos E. Ferreira Lopes, Elisa R. Garro, Zhen Guo, Maren Hempel, Philip W. Lucas, Daniel Majaess, Roberto K. Saito, A. Katherina Vivas   +15 more
openaire   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source