Results 41 to 50 of about 66,871 (257)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Protein-based signatures of functional evolution in Plasmodium falciparum

BMC Evolutionary Biology, 2011
Background It has been known for over a decade that Plasmodium falciparum proteins are enriched in non-globular domains of unknown function. The potential for these regions of protein sequence to undergo high levels of genetic drift provides a ...
Day Nicholas PJ, Bustamante Leyla Y, Sinha Ipsita, Gardner Kate B, White Nicholas J, Woodrow Charles J   +5 more
doaj   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Distinct Thermal Response of SARS-CoV-2 Spike Proteins S1 and S2 by Coarse-Grained Simulations

Biophysica
Large-scale computer simulations were employed to investigate the conformational response of the spike protein components S1 and S2 using a coarse-grained model.
Pornthep Sompornpisut, Linh Truong Hoai, Panisak Boonamnaj, Brian G. Olson, Ras B. Pandey   +4 more
doaj   +1 more source

PBF‐LB/M of Ti‐6Al‐4V: High‐Pressure Solution Treatment and Aging for Applications in a Sustainable Aerospace

Advanced Engineering Materials, EarlyView.
Additive manufacturing (AM) allows great geometric freedom for lightweight components. As parts are progressively optimized exploiting potentials in AM leading in smaller material cross sections, high pressure solution treating and aging (STA) treatments show an enormous potential for strongly improving material properties.
Mika León Altmann, Andre Danzig, Freerk Syassen, Rainer Fechte‐Heinen, Anastasiya Toenjes   +4 more
wiley   +1 more source

Bioinformatic and Experimental Evaluation of Compounds Targeting Acinetobacter baumannii

Trends in Pharmacy
Background: This study combined cheminformatics and in vitro approaches to identify novel antimicrobial compounds against Acinetobacter baumannii, a major multidrug- resistant ESKAPE pathogen.
Eslem Mert, Ebru Yücebağ Duranay
doaj   +3 more sources

Effect Of Fly Ash Content on Microstructure and Mechanical Properties of Aluminium Matrix Composite Processed by Cooling Slope Casting

Diyala Journal of Engineering Sciences
Metal matrix composites (MMCs) have emerged as promising materials for aerospace and automotive applications due to their enhanced mechanical performance.
Mohammad Na'aim Abd Rahim, Mohd Shukor Salleh, Saifudin Hafiz Yahaya, Sivarao Subramonian, Azrin Hani Abdul Rashid, Salah Salman Al-Zubaidi, Muhammad Hisyam Abdul Aziz   +6 more
doaj   +1 more source

Laser Metal Powder Deposition of Titanium Microalloyed HSLA Steel FeC0.12Si0.25Mn1.3

Advanced Engineering Materials, EarlyView.
This study investigates the additive manufacturing of titanium‐doped high‐strength low‐alloy (HSLA) steel via laser metal deposition. It reveals distinct process‐structure relationships for elemental powder blends compared to prealloyed feedstocks.
Olaf Stelling, Matthias Steinbacher, Nils Ellendt   +2 more
wiley   +1 more source

Osteogenesis and neurogenesis: a robust link also for language evolution

Frontiers in Cellular Neuroscience, 2015
This paper seeks to contribute to the characterization of the relation between osteogenesis and neurogenesis by approaching it from the field of the neurobiology of language and cognition; specifically, from an evolutionary perspective.
C. Boeckx, A. Benítez‐Burraco
semanticscholar   +1 more source