Results 51 to 60 of about 113,146 (196)

Alemtuzumab Exposure and T Lymphocyte Depletion: A Population Pharmacokinetic‐Pharmacodynamic Model of Alemtuzumab Induction Therapy for Kidney Transplantation

Clinical Pharmacology &Therapeutics, EarlyView.
Alemtuzumab is a T cell‐depleting monoclonal antibody that is used for the prevention of kidney transplant rejection. The duration of lymphodepletion after the current standard induction therapy dose is likely longer than necessary, resulting in prolonged T cell lymphopenia with the associated risk of infections. Here, the interplay between alemtuzumab
Lukas K. van Vugt, Tom C. Zwart, Suzanne Bezstarosti, Sebastiaan Heidt, Marlies E. J. Reinders, Dennis A. Hesselink, Aiko P. J. de Vries, Brenda C. M. de Winter, Dirk Jan A. R. Moes   +8 more
wiley   +1 more source

Studies of hepatic synthesis in vivo of plasma proteins, including orosomucoid, transferrin, α-antitrypsin, C8, and factor B [PDF]

, 1980
Serum protein types were determined in eight recipients and donors in cases of hepatic homotransplantation. A change from recipient type to donor type was observed for factor B, C8, orosomucoid, haptoglobin, transferrin, α1-antitrypsin, C3 and C6, but ...
Alper, Alper, Alper, Alper, Borel, Brade, Bruce H. Petersen, Chester A. Alper, Donald Raum, Einstein, Frants, Hirschfeld, Hobart, Hobart, Johnson, Kashiwagi, Kashiwagi, Kühnl, Merrill, Miller, Miller, Paul D. Taylor, Petersen, Raum, Rother, Smithies, Starzl, Thomas E. Starzl, Witherspoon, Zuheir L. Awdeh   +29 more
core   +1 more source

Mercaptans in malodorants break disulfide bridges in human serum albumin and form adducts suitable as biomarkers of exposure in vitro

Drug Testing and Analysis, EarlyView.
Disulfide adducts of mercaptans with cysteine residues in human serum albumin were detected as tripeptides and dipeptides after proteolysis with proteinase K. All peptide adducts were detected simultaneously with a mass spectrometry‐based method working in the scheduled multiple reaction monitoring (sMRM) mode.
Paula Helena Sieber, Dirk Steinritz, Franz Worek, Harald John   +3 more
wiley   +1 more source

Antibody localization in horse, rabbit, and goat antilymphocyte sera [PDF]

, 1970
The localization of antibodies was studied in rabbit, goat, and horse ALS raised by weekly immunization with canine or human spleen cells for 4 to 12 weeks.
Jacobs, R, Kapur, B, Kashiwagi, N, Ono, K, Sherer, D, Starzl, TE, Townsend, CM   +6 more
core  

Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. [PDF]

, 2000
Protease-activated receptor (PAR)-1 is a cellular receptor for thrombin that is activated after proteolytic cleavage. The contribution of PAR-1 to inflammatory cell-mediated renal injury was assessed in murine crescentic glomerulonephritis (GN).
Bernatowicz, Bohm, Bradford, Connolly, Cunningham, Erlich, Grandaliano, Holdsworth, Huang, Ishihara, Kahn, Li, Mari, Mueller, Naish, Neale, Nicholson, Nystedt, Rasmussen, Rydel, Shankar, Stone, Taylor, Taylor, Thomson, Tipping, Tipping, Tipping, Ueno, Vu, Vu, Woolkalis, Xu, Xu   +33 more
core   +3 more sources

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Actin, α-actinin, and tropomyosin interaction in the structural organization of actin filaments in nonmuscle cells [PDF]

, 1975
During the spreading of a population of rat embryo cells, approximately 40% of the cells develop a strikingly regular network which precedes the formation of the straight actin filament bundles seen in the fully spread out cells.
Lazarides, Elias
core   +1 more source

Immune Checkpoint Inhibitors and Cardiovascular Adverse Events

ESC Heart Failure, EarlyView.
Abstract In the last years, we assisted to a tremendous increase in therapeutic options for the management of cancers, with immunotherapy at the forefront of this innovation. Immune checkpoint inhibitors (ICIs) have been developed to enhance the activity of the immune system against cancer cells (1) and the number of approvals for ICIs has rapidly ...
Maria Luisa De Perna, Elia Rigamonti, Raffaele Zannoni, Vittoria Espeli, Giorgio Moschovitis   +4 more
wiley   +1 more source

Sex Hormone-Binding Globulin Levels Are Inversely Associated With Nonalcoholic Fatty Liver Disease in HIV-Infected and -Uninfected Men. [PDF]

, 2019
BackgroundNonalcoholic fatty liver disease (NAFLD) is a leading cause of liver disease worldwide. Elevated sex hormone-binding globulin (SHBG) levels have been observed in the setting of HIV and may protect against some metabolic disorders.
Brown, Todd T, Budoff, Matthew J, Kingsley, Lawrence A, Lake, Jordan E, Palella, Frank J, Post, Wendy S, Price, Jennifer C, Seaberg, Eric C, Thio, Chloe L, Wang, Ruibin, Witt, Mallory D   +10 more
core  

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source