Results 41 to 50 of about 8,289 (149)

The impact of reclassification of C3 predominant glomerulopathies on diagnostic accuracy, outcome and prognosis in patients with C3 glomerulonephritis

BMC Nephrology, 2020
Background C3 glomerulonephritis is a recently described entity with heterogeneous histopathological features. This study was conducted to assess the effect of reclassification of C3 glomerulopathies on renal outcomes, mortality, and response to therapy.
P. Puri, G. D. Walters, M. N. Fadia, M. Konia, K. A. Gibson, S. H. Jiang   +5 more
doaj   +1 more source

Randomised, phase 1 evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of iptacopan in healthy volunteers

British Journal of Pharmacology, Volume 183, Issue 11, Page 2874-2889, June 2026.
Abstract Background and Purpose Overactivation of the alternative pathway (AP) underlies several diseases. Iptacopan is an oral, first‐in‐class, highly potent specific inhibitor of factor B, a key AP protease. Experimental Approach The analysis included data from two phase 1 randomised, volunteer‐blinded, placebo‐controlled studies: Study 1, a single ...
Irina Baltcheva, Guido Junge, Kenneth Kulmatycki, Robert Schmouder, Anna Schubart, Marie‐Anne Valentin   +5 more
wiley   +1 more source

A Framework for Emergency Department–Integrated Hepatitis C Test‐and‐Treat in the United States

Journal of Viral Hepatitis, Volume 33, Issue 6, June 2026.
ABSTRACT Despite the availability of curative, direct‐acting antiviral therapy, hepatitis C virus elimination remains incomplete. Losses across the care cascade continue to limit impact, from initial diagnosis to sustained virologic response. Fewer than 1/3 of individuals ultimately achieve cure. These gaps reflect a delivery system that does not align
Saeed S. Graham
wiley   +1 more source

Immunotactoid glomerulopathy and chronic lymphocytic leukemia: The need for a multidisciplinary approach

eJHaem, 2023
Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in western countries. The association between CLL and glomerular disease (GD) is rare. The most frequent GD associated with CLL is membranoproliferative membranous glomerulonephritis (
Angela Rago, Laura Pettorini, Alessandro Andriani, Tommaso Caravita di Toritto   +3 more
doaj   +1 more source

Late Presentation of de Novo Proliferative Glomerulonephritis With Monoclonal IgG Deposits in a Renal Allograft: A Rare Case With an Unusual Clinical Course

Nephrology, Volume 31, Issue 6, June 2026.
ABSTRACT Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is a form of monoclonal gammopathy of renal significance (MGRS) in which monoclonal immunoglobulin deposits are found within the glomerulus, without involvement of other renal compartments.
Hayley J. Duxbury, David A. Brown, Adrian Y. S. Lee, Germaine Wong, Fiona Kwok, Seethalakshmi Viswanathan   +5 more
wiley   +1 more source

Kimura’s disease with membranoproliferative glomerulonephritis: a case report with literature review

Renal Failure, 2019
Background: Kimura's disease is a rare disease and its etiology is still unclear. Here we reported a case with lymphadenopathy complicated with secondary membranoproliferative glomerulonephritis.
Sensen Su, Xin Chen, Jia Li, Jinyu Yu, Li Zhang   +4 more
doaj   +1 more source

A Case of Proliferative Glomerulonephritis with Monoclonal IgG Deposits That Showed Predominantly Membranous Features

Case Reports in Nephrology, 2017
In 2004, the novel category of monoclonal IgG deposition disease has been proposed and termed “proliferative glomerulonephritis with monoclonal IgG deposits” (PGNMID). This disease is characterized by membranoproliferative glomerulonephritis and staining
Homare Shimohata, Kentaro Ohgi, Hiroshi Maruyama, Yasunori Miyamoto, Mamiko Takayashu, Kouichi Hirayama, Masaki Kobayashi   +6 more
doaj   +1 more source

Membranoproliferative Glomerulonephritis and Persistent Hypocomplementaemia [PDF]

BMJ, 1970
The clinical, laboratory, and histological findings of 50 patients with membranoproliferative glomerulonephritis are described. Three-quarters of the patients, who were mostly older children and young adults, presented clinically with a mixture of "nephritic" and "nephrotic" symptoms; the remaining quarter had no symptoms and were diagnosed after the ...
J S, Cameron, E F, Glasgow, C S, Ogg, R H, White   +3 more
openaire   +2 more sources

GloPath: An Entity‐Centric Foundation Model for Glomerular Lesion Assessment and Clinicopathological Insights

Advanced Science, Volume 13, Issue 29, 22 May 2026.
An entity‐centric foundation model, GloPath, is introduced for comprehensive glomerular lesion assessment from routine renal biopsy images. Trained on over one million glomeruli, the framework enables robust lesion recognition, grading, and cross modality diag nosis, while uncovering large‐scale clinicopathological associations.
Qiming He, Jing Li, Tian Guan, Yifei Ma, Zimo Zhao, Yanxia Wang, Hongjing Chen, Yingming Xu, Shuang Ge, Yexing Zhang, Yizhi Wang, Xinrui Chen, Lianghui Zhu, Yiqing Liu, Qingxia Hou, Shuyan Zhao, Xiaoqin Wang, Lili Ma, Peizhen Hu, Qiang Huang, Zihan Wang, Zhiyuan Shen, Junru Cheng, Siqi Zeng, Jiurun Chen, Zhen Song, Chao He, Zhe Wang, Yonghong He   +28 more
wiley   +1 more source

Dermatomyositis Sine Myositis with Membranoproliferative Glomerulonephritis

Case Reports in Rheumatology, 2012
Dermatomyositis (DM) is an autoimmune disease that is characterized by involvement of proximal musculature and skin. We report a 52-year-old woman with a 6-year history of dermatomyositis sine myositis, who developed lower extremity edema and proteinuria.
Mohammad Bagher Owlia, Roya Hemayati, Shokouh Taghipour Zahir, Mohammad Moeini Nodeh   +3 more
doaj   +1 more source