Results 31 to 40 of about 637 (143)

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

A patient with HIV infection presenting with diffuse membranous glomerulonephritis in a country with a low HIV prevalence—Remarkable remission with therapy

Journal of Infection and Public Health, 2012
Summary: The most common manifestation of HIV in the kidney is HIV-associated nephropathy (HIVAN). In this report, we describe the first documented case of membranous glomerulonephritis in an HIV-positive individual in Turkey, the country with the lowest
Selda Aydin, Bilgül Mete, Mesut Yilmaz, Gulsah Yenidünya, Reşat Zaras, Aydın Tunckale, Fehmi Tabak   +6 more
doaj   +1 more source

Tacrolimus exposure during pregnancy in kidney and liver transplantation recipients: A comparison between whole blood and plasma concentration‐to‐dose ratios

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tacrolimus monitoring is generally performed in whole blood (WB). Most (>85%) of circulating tacrolimus is bound to red blood cells. During pregnancy, WB monitoring might be suboptimal because of physiological changes including increased plasma volume and decreased haematocrit.
Jildau R. Meinderts, Paola Mian, Frederike G. I. van Vilsteren, Karien M. H. van de Wetering, Jelmer R. Prins, Stefan P. Berger, Daan J. Touw, Margriet F. C. de Jong   +7 more
wiley   +1 more source

Isorhamnetin Alleviates Renal Fibrosis Induced by Renal Tubular Epithelial Cell Senescence Via Inhibition of the IL‐6/IL‐6R Signaling Pathway

iMetaMed, EarlyView.
IL‐6 from RTECs upregulates TGF‐β in macrophages, promoting fibroblast transdifferentiation. Isorhamnetin inhibits this effect. ABSTRACT Chronic kidney disease (CKD) is a major global health issue. Kidney fibrosis is a key mechanism leading to end‐stage renal disease.
Weifei Liang, Xiangqiu Chen, Tao Wu, Xichun Zheng, Shaohua Zeng, Qingchun Zhou, Wen Ma, Hao Lin, Donglin Sun   +8 more
wiley   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Forsythiaside A Alleviates Kidney Injury and Intestinal Epithelium Dysfunction in IgA Nephropathy by Inhibiting TLR4/NF‐κB Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT IgA nephropathy (IgAN), the most common form of glomerulonephritis, is a major and growing public health issue. It results from intestinal barrier dysfunction that leads to mesangial deposition of pathogenic galactose‐deficient IgA1 (Gd‐IgA1) and renal inflammation.
Meng‐Si Li, Kai Liu
wiley   +1 more source

Anti-phospholipase A2 Receptor Antibody-Positive Membranous Glomerulopathy due to Anti-Koch’s Therapy in a Tuberculosis Patient

Saudi Journal of Kidney Diseases and Transplantation, 2021
Tuberculosis (TB)-associated glomerulonephritis is difficult to diagnose that usually presents with hematuria, proteinuria, edema, hypertension, or renal insufficiency, which is similar to symptoms of primary glomerulonephritis.
Manish R. Balwani, Amit S. Pasari, Amol Bhawane, Priyanka Tolani   +3 more
doaj   +1 more source

Segmental Membranous Glomerulonephritis in Children [PDF]

Clinical Journal of the American Society of Nephrology, 2006
Generally, idiopathic membranous glomerulonephritis (MGN) is a global glomerular disease that affects the whole of the glomerulus. However, idiopathic segmental MGN (SMGN) that shows IgG deposits in a portion of the glomerulus is encountered often. For clarification of whether SMGN is the same entity as idiopathic global MGN (GMGN), the two diseases ...
Mina, Obana, Koichi, Nakanishi, Mayumi, Sako, Nahoko, Yata, Kandai, Nozu, Ryojiro, Tanaka, Kazumoto, Iijima, Norishige, Yoshikawa   +7 more
openaire   +2 more sources

Comparison of Biocompatibility and Efficacy of Regional Citrate Anticoagulation and Unfractionated Heparin During Expanded Hemodialysis With a Medium Cut‐Off Membrane—A Randomized Trial

Artificial Organs, EarlyView.
In a randomized cross‐over trial, regional citrate anticoagulation provided superior biocompatibility over full‐dose unfractionated heparin during expanded hemodialysis with significantly lower activation of complement, granulocytes, and platelets without affecting dialysis efficiency. ABSTRACT Background Regional citrate anticoagulation (RCA) improves
Marija Malgaj Vrečko, Jernej Pajek, Jakob Gubenšek, Samo Hudoklin, Joško Osredkar, Mojca Božič Mijovski, Aleš Jerin, Jadranka Buturović‐Ponikvar   +7 more
wiley   +1 more source