Results 41 to 50 of about 110,373 (249)

IgA-codominant Post-streptococcal Glomerulonephritis in a Patient with Type 1b Abernethy Malformation: A New Insight into the Pathogenesis

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Post-streptococcal glomerulonephritis is an immune complex-mediated glomerulonephritis as a result of transient dysregulation of alternate complement pathway along with in situ immune complex formation.
Shashank M. Shivanna, Umesha Lingaraj, Kishan Aralapuram, Bhushan C. Shetty, C. G. Sreedhara   +4 more
doaj   +1 more source

WT1 complete gonadal dysgenesis with membranoproliferative glomerulonephritis: case series and literature review [PDF]

, 2022
BACKGROUND: Intronic WT1 mutations are usually causative of Frasier syndrome with focal segmental glomerulosclerosis as the characteristic nephropathy. Membranoproliferative glomerulonephritis is not commonly associated with disorders of sex development ...
Harraway, James, McManus, Sam, Aldridge, Melanie, Stewart, Anna, Anderson, Erin, Turner, Ross, Borzi, Peter, Trnka, Peter, Burke, John, Coman, David, Peter Borzi, Erin Anderson, John Burke, David Coman, Ross Turner, Melanie Aldridge, Anna Stewart, Peter Trnka, James Harraway, Sam McManus   +19 more
core   +1 more source

From Interferon Signature to the Clinical Landscape: Type I Interferonopathies

Arthritis &Rheumatology, EarlyView.
Objective TypeI interferonopathies are heterogeneous diseases driven by dysregulated type I interferon (IFN‐I) signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. The aim of this study was to characterize the clinical, immunologic, genetic, molecular profiles of patients with suspected ...
Ismail Yaz, Seza Ozen, Hacer Neslihan Bildik, Canberk Ipsir, Dilara Unal, Saliha Esenboga, Begum Cicek, Mehmet Emin Seker, Fatima Aerts‐Kaya, Seher Sener, Mehmet Orhan Erkan, Hanife Avci, Deniz Cagdas, Ilhan Tezcan   +13 more
wiley   +1 more source

Type I Interferon Drives Dysfunction of a Distinct CD8+ HLA‐DRB1+ T Cell Subset in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is characterized by type I interferon (IFN) signaling and adaptive immune dysregulation. We previously identified hypomethylation of HLA‐DRB1 and STAT1 in SLE CD8+ T cells, enabling aberrant IFN‐driven HLA‐DRB1 expression and expansion of a distinct CD8+ T cell subset. This study characterized CD8+ HLA‐DRB1+
Huizhong Long, Elio Carmona, Mikhail G. Dozmorov, Amr H. Sawalha   +3 more
wiley   +1 more source

Clinical Characteristics of Pediatric Acute Post-streptococcal Glomerulonephritis at Minia University Children Hospital

Minia Journal of Medical Research
Background: Acute post-streptococcal glomerulonephritis is an immune-mediated kidney disease, most commonly seen in children after infection with group A β-hemolytic streptococci. While some children are asymptomatic, others present with edema, hematuria,
Essam Ahmed, Rabeh Saleh, Heba Mohamed Tawfik, Salwa Swelam   +3 more
doaj   +1 more source

CASTOR1 Regulates Humoral Immune Responses and Contributes to the Pathogenesis of Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective CASTOR1 senses arginine and regulates mammalian target of rapamycin complex 1 (mTORC1), a central metabolic signaling molecule. This study aimed to elucidate the roles of CASTOR1 in humoral immune responses. Methods We analyzed human B cell transcriptomes from healthy controls and patients with systemic lupus erythematosus (SLE) via ...
Takeshi Kusuda, Toshihiko Komai, Takahiro Itamiya, Tatsuki Abe, Tomohisa Okamura, Keishi Fujio   +5 more
wiley   +1 more source

Patterns of glomerular disease based on 4-year kidney biopsy material analyzed by light microscopy and immunofluorescence: a retrospective single-center analysis in Poland

Polish Journal of Pathology, 2017
The aim of this study was to assess the epidemiology of different patterns of chronic glomerular diseases based on clinical, histopathological and immunofluorescent findings of glomerulonephritis patients hospitalized in the Department of Nephrology ...
Anna Olewicz-Gawlik, Dorota Sikorska, Agnieszka Pluto-Prądzyńska, Magdalena Roszak, Ilona Idasiak-Piechocka, Krzysztof Pawlaczyk, Andrzej Oko, Aldona Woźniak, Katarzyna Iwanik, Grzegorz Dworacki, Jan Sikora, Jan Żeromski   +11 more
doaj   +1 more source

Lithium‐related adverse drug reactions in children: A case–control study comparing lithium to second‐generation antipsychotics in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to improve the understanding of lithium's safety profile by analysing the frequency and distribution of reported adverse drug reactions (ADRs) compared to second‐generation antipsychotics (SGAs). Methods Individual case safety reports from VigiBase (1968–October 2023) involving individuals older than 2 years, with lithium or SGAs ...
Lisa T. Ringeling, Ravish N. Gangapersad, Lillian Lieuw, Patrick C. Souverein, Eibert R. Heerdink, Pilar Garcia‐Gomez, Manon H. J. Hillegers, Birgit C. P. Koch, Bram Dierckx   +8 more
wiley   +1 more source

Gender difference in crescentic glomerulonephritis; an eleven-year single-center study [PDF]

Journal of Nephropathology
Introduction: Crescentic glomerulonephritis is an essential kind of glomerulonephritis. According to its rapid progression and aggressiveness, recognizing its risk factors helps to manage a better treatment and outcome.
Asieh Maghami Mehr, Rohollah Valizadeh, Raha Manouchehrian, Hamid Nasri   +3 more
doaj   +1 more source

Autoimmunity and glomerulonephritis [PDF]

Postgraduate Medical Journal, 1992
Autoimmunity is now unequivocally regarded as the predominant pathogenic process underlying most forms of primary and secondary glomerulonephritis in humans. Most of the investigations so far have been focused upon humoral mechanisms. Consequently, the role of cell-mediated immunity in nephritis is still incompletely understood.
R, Saxena, C, Johansson, P, Bygren, J, Wieslander   +3 more
openaire   +2 more sources