Results 41 to 50 of about 106,721 (258)

Retinal drusen in glomerulonephritis with or without immune deposits suggest systemic complement activation in disease pathogenesis

Scientific Reports, 2022
Retinal drusen are characteristic of macular degeneration and complement activation, but also occur in C3, lupus and IgA nephropathy. This cross-sectional observational study compared drusen counts in different forms of glomerulonephritis.
P. Harraka, H. Mack, D. Colville, D. Barit, D. Langsford, T. Pianta, F. Ierino, Judy Savige   +7 more
doaj   +1 more source

Incidence of new onset glomerulonephritis after SARS-CoV-2 mRNA vaccination is not increased. [PDF]

, 2022
Numerous cases of glomerulonephritis manifesting shortly after SARS-CoV-2 vaccination have been reported, but causality remains unproven. Here, we studied the association between mRNA-based SARS-CoV-2 vaccination and new-onset glomerulonephritis using a ...
Nanchen, G., Nanchen, Giliane, Locher, Eleonore, Fischer, I., Fischer, Ingeborg, Moll, S., Boide, P., Faivre, A., Faivre, Anna, Rotman, S., Seeger, Harald; https://orcid.org/, Diebold, M., Helmchen, Birgit, Saganas, Charalampos, Kistler, Andreas D., Hopfer, H., Kim, M.J., Helmchen, B., Saganas, C., Seeger, H., Rotman, Samuel, Enzler-Tschudy, Annette, Boide, Philipp, Diebold, Matthias, Hopfer, Helmut, Enzler-Tschudy, A., Kim, Min Jeong, Kistler, A.D., Locher, E., Diebold, Matthias; https://orcid.org/, Moll, Solange, Seeger, Harald, Kistler, Andreas D   +32 more
core   +2 more sources

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

The Src-Family Kinases Hck, Fgr and Lyn Drive Immune Complex-Mediated Glomerulonephritis Through the Syk Tyrosine Kinase. [PDF]

FASEB J
The study aimed to test the role of three Src‐family kinases, Hck, Fgr, and Lyn in immune complex glomerulonephritis. Hck, Fgr, and Lyn were overexpressed in human lupus nephritis and mouse nephrotoxic nephritis. Combined genetic deficiency of the three kinases practically completely protected mice from nephrotoxic nephritis.
Lesinszki LS, Deli D, Boldizsár LK, Pánczél Á, Fintha A, Robson MG, Mócsai A.   +6 more
europepmc   +2 more sources

Acute glomerulonephritis [PDF]

Postgraduate Medical Journal, 2003
Abstract Glomerulonephritis is an important cause of renal failure thought to be caused by autoimmune damage to the kidney. While each type of glomerulonephritis begins with a unique initiating stimulus, subsequent common inflammatory and fibrotic events lead to a final pathway of progressive renal damage.
C S, Vinen, D B G, Oliveira
openaire   +2 more sources

Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Matteo Zanovello, Francesca Serani, Alen Bebeti, Federica Paredi, Giulia Quadrio, Andrea Fortuna, Giacomo Maria Minicuci, Elena Pegoraro, Annachiara Cagnin, Diego Cecchin, Gianni Sorarù   +10 more
wiley   +1 more source

Rapidly Progressive Glomerulonephritis in Autosomal Dominant Polycystic Kidney Disease

, 2015
Patients with autosomal dominant polycystic kidney disease (ADPKD) can suffer from the same causes of acute kidney injury as the general population. Affected individuals may present with hematuria and proteinuria (usually less than 1g/day).

core   +1 more source

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Membranous nephropathy in a child with crescentic glomerulonephritis: Coincidence or comorbidity?

Saudi Journal of Kidney Diseases and Transplantation, 2019
Rapidly progressive glomerulonephritis (RPGN) is rare syndrome in children, characterized by clinical features of glomerulonephritis and rapid loss of renal function, and is associated with crescentic glomerulonephritis.
Ilknur Girisgen, Seçil Conkar, İpek Kaplan Bulut, Sait Şen, Sevgi Mir   +4 more
doaj   +1 more source