Results 161 to 170 of about 48,150 (297)

How the mosquito's carbon dioxide sense gets an internal boost. [PDF]

PLoS Biol
Su CY.
europepmc   +1 more source

Comparing outcomes using low‐dose apixaban and anti‐Xa monitoring and vitamin K antagonists in patients with renal replacement therapy

British Journal of Clinical Pharmacology, EarlyView.
Background Guidelines recommend oral anticoagulation for stroke prevention in atrial fibrillation and secondary prevention of venous thromboembolism. Outside the United States, apixaban is unlicensed for use in patients with end‐stage renal disease (ESRD) receiving renal replacement therapy (RRT).
John K. Bartoli‐Abdou, Alexander T. Cohen, Lucy Vernon, Victoria Collings, Ubonphan Chaichana, Natasha Moore, Hamda Jibril, Li Wei, Nicola Kumar, Karen A. Breen, Andrew J. Doyle   +10 more
wiley   +1 more source

Pathways for glomerular macromolecule filtration: A mathematical model for transport across glomerular filtration surface, mesangium and shear-induced shunts. [PDF]

PLoS Comput Biol
Punyaratabandhu N, Pankoh T, Roongthumskul Y, Dechadilok P, Katavetin P.   +4 more
europepmc   +1 more source

Translational development of crisugabalin for neuropathic pain

British Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João, Jilly Octoria Tagore Chan, Luísa Mendes Araújo, André Batista João, Raquel Mattos Filgueiras, Paulo César Ragazzo   +5 more
wiley   +1 more source

Beat- and Side-family cell-surface molecules are expressed combinatorially in the partner neurons of the olfactory circuit in Drosophila. [PDF]

PLoS Biol
Duan Q, Okuwa S, Estrella R, Yeung C, Chen YD, Rio LQ, Du C, Vien KM, Volkan PC.   +8 more
europepmc   +1 more source

CYP3A5 genetic variability influences sildenafil and metabolite in pulmonary hypertension

British Journal of Clinical Pharmacology, EarlyView.
Aim Interindividual variability in sildenafil response among pulmonary hypertension patients (PH) may be influenced by CYP3A5 polymorphisms. CYP3A5*3 allele reduces CYP3A5 activity and affects sildenafil metabolism. This study investigated the associations between CYP3A5 genotype and plasma concentrations of sildenafil and N‐desmethyl sildenafil, as ...
Pranisa Wongwien, Burabha Pussadhamma, Sirimas Kanjanawart, Thikhumporn Areesinpitak, Nontaya Nakkam, Chingching Foocharoen, Wichittra Tassaneeyakul, Suda Vannaprasaht   +7 more
wiley   +1 more source

Modulation of habenula axon terminals supports action-outcome associations in larval zebrafish. [PDF]

Nat Commun
Paoli E, Palieri V, Shenoy A, Portugues R.   +3 more
europepmc   +1 more source

Pharmacokinetic and pharmacodynamic interaction of enavogliflozin, a sodium‐glucose cotransporter 2 inhibitor, with glimepiride and metformin in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims Enavogliflozin, a sodium‐glucose cotransporter 2 inhibitor, is expected to be coadministered with antihyperglycaemic drugs with different mechanisms of action. This study aimed to investigate the pharmacokinetic (PK) and pharmacodynamic (PD) interactions between enavogliflozin, glimepiride and metformin.
Kyungrin Chang, Yoonjin Kim, Daye Jung, Jae Min Cho, Joo‐Youn Cho, SeungHwan Lee   +5 more
wiley   +1 more source

Immature olfactory sensory neurons provide complementary input in the intact olfactory system. [PDF]

iScience
Gregory JD, Herzog RS, Curtis KA, Marar MI, Cheetham CEJ.   +4 more
europepmc   +1 more source

Tenofovir diphosphate intracellular concentration following tenofovir alafenamide administration in bictegravir‐containing vs. dolutegravir‐containing antiretroviral regimens

British Journal of Clinical Pharmacology, EarlyView.
This study investigates intracellular (IC) exposure of tenofovir alafenamide (TAF) and its clinical determinants in experienced people living with HIV. We conducted a monocentric retrospective analysis of 86 adults treated with either bictegravir (BIC)‐ or dolutegravir (DTG)‐containing regimen. Plasma and IC trough concentrations (Ctrough) of tenofovir
Micol Ferrara, Viviana Maccario, Silvia Fantino, Erica Clemente, Federica Barrera, Alice Palermiti, Sara Soloperto, Amedeo De Nicolo, Antonio D'Avolio, Giovanni Di Perri, Stefano Bonora   +10 more
wiley   +1 more source