Results 21 to 30 of about 85,679 (96)

Discrepancy between the Actions of Glucagon-like Peptide-1 Receptor Ligands in the Protection of the Heart against Ischemia Reperfusion Injury

Pharmaceuticals, 2022
Tirzepatide is a dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist and a promising therapy for type 2 diabetes mellitus (T2DM). GLP-1 is an incretin hormone with therapeutic potential beyond type
Ali Ismaeil, Fawzi Babiker, Suleiman Al-Sabah   +2 more
doaj   +1 more source

GLP-1 RAs for Treating Metabolic Dysfunction-Associated Steatosis Liver Disease: From GLP-1 Discovery to FDA Approval: A Comprehensive Narrative Review

Pharmaceuticals
Background: Metabolic dysfunction-associated steatosis liver disease (MASLD), formerly termed nonalcoholic fatty liver disease (NAFLD), has emerged as the most prevalent cause of chronic liver disease worldwide.
Olfa Khalifa, Abdelilah Arredouani
doaj   +1 more source

Chronic exposure to GLP-1 increases GLP-1 synthesis and release in a pancreatic alpha cell line (α-TC1): evidence of a direct effect of GLP-1 on pancreatic alpha cells.

PLoS ONE, 2014
Aims/hypothesisIncretin therapies, which are used to treat diabetic patients, cause a chronic supra-physiological increase in GLP-1 circulating levels.
Salvatore Piro, Loriana G Mascali, Francesca Urbano, Agnese Filippello, Roberta Malaguarnera, Salvatore Calanna, Agata M Rabuazzo, Francesco Purrello   +7 more
doaj   +1 more source

Recent advances in understanding the role of glucagon-like peptide 1 [version 1; peer review: 2 approved]

F1000Research, 2020
The discovery that glucagon-like peptide 1 (GLP-1) mediates a significant proportion of the incretin effect during the postprandial period and the subsequent observation that GLP-1 bioactivity is retained in type 2 diabetes (T2D) led to new therapeutic ...
Josh Reed, Stephen Bain, Venkateswarlu Kanamarlapudi   +2 more
doaj   +1 more source

Reduction in GLP-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis

Scientific Reports, 2021
Multiple factors regulate glucagon-like peptide-1 (GLP-1) secretion, but a group of apparently healthy subjects showed blunted responses of GLP-1 secretion in our previous study.
Chihiro Nagase, Masaya Tanno, Hidemichi Kouzu, Takayuki Miki, Junichi Nishida, Naoto Murakami, Nobuaki Kokubu, Nobutaka Nagano, Ryo Nishikawa, Nobuhiro Yoshioka, Tohru Hasegawa, Hiroyuki Kita, Akihito Tsuchida, Hirofumi Ohnishi, Tetsuji Miura   +14 more
doaj   +1 more source

Hepatic function of glucagon-like peptide-1 and its based diabetes drugs

Medical Review
Incretins are gut-produced peptide-hormones that potentiate insulin secretion, especially after food intake. The concept of incretin was formed more than 100 years ago, even before insulin was isolated and utilized in the treatment of subjects with type ...
Feng Jia Nuo, Jin Tianru
doaj   +1 more source

Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes

Molecular Metabolism, 2020
Objectives: Our study shows that glucagon-like peptide-1 (GLP-1) is secreted within human islets and may play an unexpectedly important paracrine role in islet physiology and pathophysiology.
Scott A. Campbell, Dominic P. Golec, Matt Hubert, Janyne Johnson, Nicole Salamon, Amy Barr, Patrick E. MacDonald, Koenraad Philippaert, Peter E. Light   +8 more
doaj   +1 more source

Glucagon-like peptide 1 (GLP-1)

Molecular Metabolism, 2019
Background: The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying ...
T.D. Müller, B. Finan, S.R. Bloom, D. D'Alessio, D.J. Drucker, P.R. Flatt, A. Fritsche, F. Gribble, H.J. Grill, J.F. Habener, J.J. Holst, W. Langhans, J.J. Meier, M.A. Nauck, D. Perez-Tilve, A. Pocai, F. Reimann, D.A. Sandoval, T.W. Schwartz, R.J. Seeley, K. Stemmer, M. Tang-Christensen, S.C. Woods, R.D. DiMarchi, M.H. Tschöp   +24 more
doaj   +1 more source

Chicken Intestinal L Cells and Glucagon-like Peptide-1 Secretion

The Journal of Poultry Science, 2020
Many types of endocrine cells have been identified in the gastroenteropancreatic system of vertebrates, which have subsequently been named with alphabet (s).
Kohzy Hiramatsu
doaj   +1 more source

Glucagon-like peptide-1 and glucagon-like peptide-2 regulation during human liver regeneration

Scientific Reports, 2023
Accumulating evidence suggests that metabolic demands of the regenerating liver are met via lipid metabolism and critical regulators of this process. As such, glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) critically affect hepatic ...
Markus Ammann, Jonas Santol, David Pereyra, Tamara Kalchbrenner, Tanja Wuerger, Johannes Laengle, Rory L. Smoot, Wolfgang Hulla, Friedrich Laengle, Patrick Starlinger   +9 more
doaj   +1 more source