ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential
iNew Medicine, EarlyView.ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang +5 more
wiley +1 more source
Glucagon-like Peptide 2 (GLP-2) [PDF]
, 2004 Julie Lovshin, Daniel J. Drucker
openaire +1 more source
Conformational Dynamics of Glucagon-like Peptide-2 with Different Electric Field. [PDF]
Polymers (Basel), 2022 Su J, Sun T, Wang Y, Shen Y.
europepmc +1 more source
Research Progress of Berberine in Kidney Disease: Targeting Mitochondria and Ferroptosis
iNew Medicine, EarlyView.This figure illustrates the model‐specific renoprotective mechanisms of berberine (BBR) across three major kidney diseases. From left to right, the diagram shows that BBR targets distinct core pathways depending on the pathological context: in diabetic nephropathy (DN), BBR activates AMPK to improve mitochondrial energy metabolism; in acute kidney ...
Liuqing Wang +3 more
wiley +1 more source
Exenatide extended-release; clinical trials, patient preference, and economic considerations
Patient Preference and Adherence, 2013 Sheila A DoggrellSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, AustraliaAbstract: Type 2 diabetes remains an escalating problem worldwide, despite a range of treatments being available.
Doggrell SA
doaj
Glucagon-like peptide-2 analogues for Crohn's disease patients with short bowel syndrome and intestinal failure. [PDF]
World J Gastroenterol, 2022 Pizzoferrato M +4 more
europepmc +1 more source
Journal of Hospital Medicine, EarlyView.Abstract Health‐related social needs (HRSN) significantly influence patient outcomes, yet they are rarely integrated into point‐of‐care decision‐making. We developed a process to embed HRSN‐informed and HRSN‐targeted care recommendations directly into three electronic health record‐integrated high‐use clinical pathways—cirrhosis, diabetes, and ...
Karthik Warke Rohatgi +5 more
wiley +1 more source
Pharmacokinetics of Glepaglutide, A Long-Acting Glucagon-Like Peptide-2 Analogue: A Study in Healthy Subjects. [PDF]
Clin Drug Investig, 2022 Agersnap MA +4 more
europepmc +1 more source
Congenital short bowel syndrome: Clinical aspects by systematic review
JPGN Reports, EarlyView.Abstract Objectives Congenital short bowel syndrome (CSBS) is a rare intestinal disorder characterized by inborn shortening of the bowel with mainly mutations in Coxsackie and Adenovirus receptor‐like membrane protein (CLMP) and Filamin A (FLNA) genes.
Barblin Remund +2 more
wiley +1 more source
Evaluation of Intestinal Barrier Biomarkers and Glucagon-like Peptide-2 in SIRS-Positive and SIRS-Negative Diarrheic Calves. [PDF]
Animals (Basel)Şahan A +4 more
europepmc +1 more source