Results 171 to 180 of about 28,560,894 (288)

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Longitudinal single-cell analysis of glucagon-like peptide-2 treatment in patients with short bowel syndrome. [PDF]

JCI Insight
Kudo Y, Miyamoto K, Suzuki S, Chida A, Tojo A, Hasegawa M, Shigehara A, Koya I, Ando Y, Sato M, Kondo A, Kumagai T, Deguchi H, Sugiyama Y, Ito Y, Shirosaki K, Yamagishi S, Maeda Y, Kanamori H, Kano M, Kato M, Tsujikawa H, Yoshimatsu Y, Takabayashi K, Okabayashi K, Kanai T, Hosoe N, Kato M, Moody J, Hon CC, Kuroda T, Yamada Y, Fujino A, Sujino T.   +33 more
europepmc   +1 more source

Effects of glepaglutide, a long-acting glucagon-like peptide-2 analog, on intestinal morphology and perfusion in patients with short bowel syndrome: Findings from a randomized phase 2 trial. [PDF]

JPEN J Parenter Enteral Nutr, 2023
Naimi RM, Hvistendahl MK, Poulsen SS, Kissow H, Pedersen J, Nerup NA, Ambrus R, Achiam MP, Svendsen LB, Jeppesen PB.   +9 more
europepmc   +1 more source

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider, Divyani Garg, Vassilena Iankova, Thomas Klopstock   +3 more
wiley   +1 more source

Glucagon-Like Peptide-2 (GLP-2) Analogues in Patients With Short Bowel Syndrome Dependent on Parenteral Support: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]

JGH Open
Hyder A, Alria A, Rafiq A, Akram MF, Hassan T, Ali EF, Vhora F, Khan S, Zahra SG, Niazi MA, Jafar U, Cheema HA, Alsubari AMA, Altaf F, Bhat A, Rashad E, Jalal PK.   +16 more
europepmc   +1 more source

Key Interventions in Friedreich's Ataxia and Their Impact on Patient Outcomes: A Systematic Review

Movement Disorders, EarlyView.
Abstract Friedreich's ataxia (FA) is a rare neurodegenerative disease with multisystemic symptoms that requires multidisciplinary care. This systematic review summarizes available pharmacological and nonpharmacological interventions, their outcomes, and alignment with patient‐centered care domains, as well as their impact on these domains.
Dorota Sarwinska, Maresa Buchholz, Audrey Iskandar, Marcus Grobe‐Einsler, Thomas Klockgether, Jennifer Faber, Bernhard Michalowsky   +6 more
wiley   +1 more source

Glucagon-Like Peptide-2 as a Potential Biomarker for Nonalcoholic Fatty Liver Disease in Children with Obesity: Preliminary Assessment of Metabolic Associations and Underlying Mechanisms. [PDF]

Diabetes Metab Syndr Obes
Zhang SJ, Xu K, Zhu F, Teng YQ, Tang YF, Xu HW.   +5 more
europepmc   +1 more source

High‐Fat Diet Exacerbates Neuropathology in a Transgenic Mouse Model of Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Multiple system atrophy (MSA) is a rare and devastating neurodegenerative disorder. Accumulating clinical and preclinical evidence suggests that diabetes and insulin resistance may adversely influence MSA pathophysiology. Objective We investigated the potential association between diabetes, impaired glucose homeostasis, and MSA ...
Marie‐Laure Arotcarena, Anna Delamarre, Miguel Lopez‐Cuina, Hugo Martin, Elio Balpe, Xavier Fioramonti, Erwan Bezard, Wassilios G. Meissner   +7 more
wiley   +1 more source

Glucagon-like Peptide-2 Acts Partially Through Central GLP-2R and MC4R in Mobilizing Stored Lipids from the Intestine. [PDF]

Nutrients
Mukherjee K, Khan MSA, Howland JG, Xiao C.   +3 more
europepmc   +1 more source

The Gut–Brain Axis in Parkinson's Disease: From Clinical Observation toward Mechanism‐Based Precision Medicine

Movement Disorders, EarlyView.
Abstract Gastrointestinal dysfunction is increasingly recognized as a core feature of Parkinson's disease (PD), affecting quality of life, nutrition, medication response, and potentially the earliest stages of pathogenesis. This perspective traces the evolution of the gut from a neglected source of non‐motor symptoms to a central component of ...
Filip Scheperjans, Per Borghammer, Ronald F. Pfeiffer, Silke Appel‐Cresswell, Ali Keshavarzian   +4 more
wiley   +1 more source