Results 261 to 270 of about 140,006 (312)
Some of the next articles are maybe not open access.
Structure of the glucagon receptor in complex with a glucagon analogue
Nature, 2018Class B G-protein-coupled receptors (GPCRs), which consist of an extracellular domain (ECD) and a transmembrane domain (TMD), respond to secretin peptides to play a key part in hormonal homeostasis, and are important therapeutic targets for a variety of diseases.
Haonan, Zhang +21 more
openaire +2 more sources
Sites of cleavage of glucagon by insulin-glucagon protease
Biochemical and Biophysical Research Communications, 1975Abstract To study the mechanism of degradation of glucagon with purified insulin-glucagon protease, glucagon was reacted with the enzyme at various times of incubation. The proteolysis was followed by the production of flourescamine-reacting material as well as reaction with dansyl chloride, cleavage by acid hydrolysis, and identification by thin ...
F K, Baskin +2 more
openaire +2 more sources
Critical Care Medicine, 1984
Glucagon is an important therapeutic agent in critical care medicine. Although its endogenous hormonal functions have been well described, its clinical uses are rarely discussed. Glucagon is effective in the treatment of hypoglycemia, cardiogenic shock and heart failure, propranolol overdose, esophageal meat impaction, ureteral colic due to calculi ...
K, Hall-Boyer, G P, Zaloga, B, Chernow
openaire +2 more sources
Glucagon is an important therapeutic agent in critical care medicine. Although its endogenous hormonal functions have been well described, its clinical uses are rarely discussed. Glucagon is effective in the treatment of hypoglycemia, cardiogenic shock and heart failure, propranolol overdose, esophageal meat impaction, ureteral colic due to calculi ...
K, Hall-Boyer, G P, Zaloga, B, Chernow
openaire +2 more sources
Annals of Internal Medicine, 1971
Excerpt To the editor: Dr. Cortes's letter (Ann Intern Med74:1014, 1971) requires some comment. The possibility of a glucagon-induced endogenous thyrocalcitonin stimulation in pancreatitis is compl...
openaire +2 more sources
Excerpt To the editor: Dr. Cortes's letter (Ann Intern Med74:1014, 1971) requires some comment. The possibility of a glucagon-induced endogenous thyrocalcitonin stimulation in pancreatitis is compl...
openaire +2 more sources
Metabolism, 1976
HE HEPATIC PRODUCTION of lipoprotein is a complex phenomenon, involving a synchronous relationship between hepatic apoprotein synthesis, and the actual tipoprotein secretory event. A role for glucagon in modulating these events has been proposed.~ The administration of exogenous glucagon results in a pronounced hypolipemic response in man, dog, fowl ...
openaire +2 more sources
HE HEPATIC PRODUCTION of lipoprotein is a complex phenomenon, involving a synchronous relationship between hepatic apoprotein synthesis, and the actual tipoprotein secretory event. A role for glucagon in modulating these events has been proposed.~ The administration of exogenous glucagon results in a pronounced hypolipemic response in man, dog, fowl ...
openaire +2 more sources
Disease-a-Month, 1978
The islets of Langerhans contain at least four major cell types—the A, A2, or α cell; the B or β cell; the D or A1 cell; and the F cell—containing, respectively, glucagon, insulin, somatostatin, and pancreatic polypeptide. In every species thus far examined, these four cell types bear a constant topographical relationship to one another, although the ...
openaire +1 more source
The islets of Langerhans contain at least four major cell types—the A, A2, or α cell; the B or β cell; the D or A1 cell; and the F cell—containing, respectively, glucagon, insulin, somatostatin, and pancreatic polypeptide. In every species thus far examined, these four cell types bear a constant topographical relationship to one another, although the ...
openaire +1 more source
Metabolism, 1973
Abstract The radioimmunoassay for glucagon has established the hormonal identity of this factor and exposed broad areas of its physiology and pathophysiology. While the ultimate importance of glucagon in man remains to be determined, there is little doubt that this previously unexplored area of endocrinology has been one of the major beneficiaries of
openaire +2 more sources
Abstract The radioimmunoassay for glucagon has established the hormonal identity of this factor and exposed broad areas of its physiology and pathophysiology. While the ultimate importance of glucagon in man remains to be determined, there is little doubt that this previously unexplored area of endocrinology has been one of the major beneficiaries of
openaire +2 more sources
The past, present, and future physiology and pharmacology of glucagon
Cell Metabolism, 2022Megan E Capozzi +2 more
exaly