Results 301 to 310 of about 213,470 (338)
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Glucagon and Glucagon-like Peptides in Fishes
1996Glucagon and glucagon-like peptides (GLPs) are coencoded in the vertebrate proglucagon gene. Large differences exist between fishes and other vertebrates in gene structure, peptide expression, peptide chemistry, and function of the hormones produced.
Thomas P. Mommsen, Erika M. Plisetskaya
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Medical Clinics of North America, 1978
We have considered the evidence, first, that the presence of glucagon is essential in the pathogenesis of the full syndrome that results from complete insulin deficiency; second, that in the diabetic in whom insulin levels are relatively fixed, a rise in glucagon concentration contributes to endogenous hyperglycemia; and, third, that conventional ...
Roger H Unger, Philip Raskin
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We have considered the evidence, first, that the presence of glucagon is essential in the pathogenesis of the full syndrome that results from complete insulin deficiency; second, that in the diabetic in whom insulin levels are relatively fixed, a rise in glucagon concentration contributes to endogenous hyperglycemia; and, third, that conventional ...
Roger H Unger, Philip Raskin
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Metabolism, 1973
Abstract The radioimmunoassay for glucagon has established the hormonal identity of this factor and exposed broad areas of its physiology and pathophysiology. While the ultimate importance of glucagon in man remains to be determined, there is little doubt that this previously unexplored area of endocrinology has been one of the major beneficiaries of
Roger H Unger, Roger H Unger
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Abstract The radioimmunoassay for glucagon has established the hormonal identity of this factor and exposed broad areas of its physiology and pathophysiology. While the ultimate importance of glucagon in man remains to be determined, there is little doubt that this previously unexplored area of endocrinology has been one of the major beneficiaries of
Roger H Unger, Roger H Unger
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1977
IN this review we examine the role of glucagon, a polypeptide produced by the islets of Langerhans and a biologic antagonist of insulin.
Roger H Unger +3 more
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IN this review we examine the role of glucagon, a polypeptide produced by the islets of Langerhans and a biologic antagonist of insulin.
Roger H Unger +3 more
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Metabolism, 1976
Although suspected to exist as a pancreatic hyperglycemic factor as early as 1923, isolated and crystallized by 1953, and measurable by radioimmunoassay since 1959, only in the last decade has glucagon become firmly established as a critical hormone in the minute-to-minute regulation of the blood glucose concentration.
J. Denis McGarry +2 more
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Although suspected to exist as a pancreatic hyperglycemic factor as early as 1923, isolated and crystallized by 1953, and measurable by radioimmunoassay since 1959, only in the last decade has glucagon become firmly established as a critical hormone in the minute-to-minute regulation of the blood glucose concentration.
J. Denis McGarry +2 more
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Annals of Internal Medicine, 1970
Excerpt Glucagon's scientific birth was a lowly one, that of a troublesome contamination of early insulin preparations.
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Excerpt Glucagon's scientific birth was a lowly one, that of a troublesome contamination of early insulin preparations.
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Structure of the glucagon receptor in complex with a glucagon analogue
Nature, 2018Class B G-protein-coupled receptors (GPCRs), which consist of an extracellular domain (ECD) and a transmembrane domain (TMD), respond to secretin peptides to play a key part in hormonal homeostasis, and are important therapeutic targets for a variety of diseases.
Ned Van Eps +21 more
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Sites of cleavage of glucagon by insulin-glucagon protease
Biochemical and Biophysical Research Communications, 1975Abstract To study the mechanism of degradation of glucagon with purified insulin-glucagon protease, glucagon was reacted with the enzyme at various times of incubation. The proteolysis was followed by the production of flourescamine-reacting material as well as reaction with dansyl chloride, cleavage by acid hydrolysis, and identification by thin ...
Abbas E. Kitabchi +5 more
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Disease-a-Month, 1978
The islets of Langerhans contain at least four major cell types—the A, A2, or α cell; the B or β cell; the D or A1 cell; and the F cell—containing, respectively, glucagon, insulin, somatostatin, and pancreatic polypeptide. In every species thus far examined, these four cell types bear a constant topographical relationship to one another, although the ...
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The islets of Langerhans contain at least four major cell types—the A, A2, or α cell; the B or β cell; the D or A1 cell; and the F cell—containing, respectively, glucagon, insulin, somatostatin, and pancreatic polypeptide. In every species thus far examined, these four cell types bear a constant topographical relationship to one another, although the ...
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Annals of Internal Medicine, 1971
Excerpt To the editor: Dr. Cortes's letter (Ann Intern Med74:1014, 1971) requires some comment. The possibility of a glucagon-induced endogenous thyrocalcitonin stimulation in pancreatitis is compl...
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Excerpt To the editor: Dr. Cortes's letter (Ann Intern Med74:1014, 1971) requires some comment. The possibility of a glucagon-induced endogenous thyrocalcitonin stimulation in pancreatitis is compl...
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