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A Comparison of Two Methods for Quantifying D-Glucaric Acid

Journal of Analytical Toxicology, 1986
The relative usefulness of two spectrophotometric methods for quantifying urinary D-glucaric acid was evaluated. The enzyme inhibition method measures the inhibition of beta-D-glucuronidase by the 1,4-glucarolactone produced from D-glucaric acid in urine by boiling at acidic pH.
K K, Steinberg, L L, Needham
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Identification of Pathways for Production of d-Glucaric Acid by Pseudogluconobacter saccharoketogenes

Applied Biochemistry and Biotechnology, 2023
Pseudogluconobacter saccharoketogenes produces glucaric acid from D-glucose via two pathways, i.e., through D-glucuronic acid or D-gluconic acid. These pathways are catalyzed by alcohol dehydrogenase, aldehyde dehydrogenase, and gluconate dehydrogenase.
Tetsuya Ito   +6 more
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Relationship between PCBs in blood and ?-glucaric acid in urine

Toxicology Letters, 2003
The polychlorinated biphenyls (PCBs) have been demonstrated to be inducers of hepatic microsomal enzymes and some of their effects such as hormonal imbalance, and alteration of lipid and porphyrin metabolism could be ascribed to this mechanism. For this reason, the urinary excretion of D-glucaric acid (DGA), an indirect indicator of enzymatic induction,
APOSTOLI, Pietro   +3 more
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[Progress in glucaric acid].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2015
Glucaric acid (GA) is derived from glucose and commonly used in chemical industry. It is also considered as one of the "Top value-added chemicals from biomass" as carbohydrate monomers to produce various synthetic polymers and bioenergy. The demand for GA in food manufacture is increasing.
Yuying, Qiu   +3 more
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HPLC Determination of d-Glucaric Acid in Human Urine

Journal of Analytical Toxicology, 1993
An isocratic HPLC method has been developed for the direct measurement of D-glucaric acid in human urine. Pretreatment of urine with a boronic acid gel removed many interfering substances, including L-ascorbic acid and D-glucuronic acid. This method has a detection limit of 10 microM D-glucaric acid (approximately 7 mumoles/g creatinine).
R, Poon   +3 more
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Rennovia licenses glucaric acid to ADM

C&EN Global Enterprise, 2017
Rennovia, a California-based start-up that develops catalytic routes to biobased chemicals, and catalyst specialist Johnson Matthey are licensing their glucaric acid technology to the agricultural giant Archer Daniels Midland for commercialization. ADM made a $25 million investment in Rennovia in 2014. Glucaric acid is used to make sodium glucarate, an
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Partnership targets glucaric acid derivatives

C&EN Global Enterprise, 2016
The Warner Babcock Institute for Green Chemistry, a technology developer, will work with the industrial biotechnology start-up Kalion to develop renewable chemicals based on glucaric acid.
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An enzymatic determination of d-glucaric acid by conversion to pyruvate

Analytical Biochemistry, 1985
A method was developed for determination of D-glucaric acid by treatment with a bacterial extract containing glucarate dehydratase and ketodeoxyglucarate aldolase. This led to the quantitative formation of pyruvate, which was then assayed by use of lactate dehydrogenase. Measurements of D-glucarate in individual samples of human urine by this technique
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[13a] d-Glucaric and some related acids

1966
Publisher Summary This chapter reveals that the D-glucarie (saccharic) acid, when isolated as the potassium acid salt following the oxidation of D-glucose with nitric acid, is contaminated with small amounts of potassium acid oxalate and potassium acid D-tartrate.
Donald C. Fish, Harold J. Blumenthal
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Cell-free enzymatic production of glucaric acid

2019
Cell-free biocatalysis with a number of enzymes is a fast growing and potentially high impact field in synthetic biology for the bio-manufacture of existing and novel fine or platform chemicals and biofuels. The assembly of multiple different enzymes to form synthetic pathways is a relatively new development in contrast to the single enzyme systems ...
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