Results 81 to 90 of about 9,202 (225)
Environmental Toxicology, EarlyView.ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye +5 more
wiley +1 more source
Modeling Parkinson’s Disease in Drosophila: What Have We Learned for Dominant Traits?
Frontiers in Neurology, 2018 Parkinson’s disease (PD) is recognized as the second most common neurodegenerative disorder after Alzheimer’s disease. Unfortunately, there is no cure or proven disease modifying therapy for PD.
Yulan Xiong, Jianzhong Yu
doaj +1 more source
Allergy, EarlyView.ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj +4 more
wiley +1 more source
Risk stratification and targeted neuroprotection in Parkinson disease utilising the glucocerebrosidase pathway [PDF]
, 2018 OBJECTIVES: Glucocerebrosidase mutations represent genetically the most significant risk factor for Parkinson disease, however their penetrance is incomplete and variable such that only a minority of glucocerebrosidase mutation carriers will develop ...
Mullin, Stephen
core
The FEBS Journal, EarlyView.Misfolding mutations in pancreatic lipase have been identified as potential contributors of chronic pancreatitis, an inflammatory disease of the human pancreas. Here, we describe the effect of these misfolding mutations on pancreatic lipase structure using molecular dynamics simulations and structural modeling.
Gyula Hoffka, András Szabó
wiley +1 more source
Glucocerebrosidase in the pathogenesis and treatment of Parkinson disease [PDF]
Proceedings of the National Academy of Sciences, 2013 In PNAS, Sardi et al. describe that viral vector-mediated increase in glucocerebrosidase enzyme (GCase) activity can reverse synuclein-related pathological features and improve behavioral function in the D409V mouse model of Gaucher disease (GD) (1). This important study has several implications for our understanding of the pathogenesis of Parkinson ...
Anthony H V, Schapira, Matthew E, Gegg
openaire +2 more sources
Association Between Glucocerebrosidase Mutations and Parkinson's Disease in Ireland
Frontiers in Neurology, 2020 Multiple studies implicate heterozygous GBA mutations as a major genetic risk factor for Parkinson's disease (PD); however, the frequency of mutations has never been examined in PD patients from the Irish population.
Diana A. Olszewska +15 more
doaj +1 more source
Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse
Experimental Physiology, EarlyView.Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley +1 more source
Comparative study on glucocerebrosidase in spleens from patients with Gaucher disease
, 1990 In Gaucher disease (glucosylceramide lipidosis), deficiency of glucocerebrosidase causes pathological storage of glucosylceramide, particularly in the spleen.
Aerts, J. M. +7 more
core +1 more source
ChemSusChem, Volume 19, Issue 13, 14 July 2026.Silicon application as a support for Pd Nanoparticle catalysts in Heck–Cassar cross‐coupling under continuous flow. Electronic waste and end‐of‐life photovoltaic modules are positioning silicon as a high‐value material that will increasingly enter the waste stream in the coming years.
Tian Sang +6 more
wiley +1 more source