Results 151 to 160 of about 74,459 (251)

Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals

Cell Proliferation, EarlyView.
One‐third of the world's population is affected by metabolic syndrome. Complicated pathogenesis and limited drugs cause the growing prevalence of metabolic syndrome. Macrophage‐mediated metaflammation is closely associated with the development of metabolic syndrome. The role of phytochemicals targeting macrophages in the treatment of metabolic syndrome
Zeting Ye, Yanlin Li, Xiaolin Yang, Chenglin Li, Rui Yu, Guangjuan Zheng, Zuqing Su   +6 more
wiley   +1 more source

Allosteric regulation of pyruvate kinase enables efficient and robust gluconeogenesis by preventing metabolic conflicts and carbon overflow. [PDF]

mSystems
She F, Anderson BW, Khana DB, Zhang S, Steinchen W, Fung DK, Lesser NG, Lucas LN, Stevenson DM, Astmann TJ, Bange G, van Pijkeren J-P, Amador-Noguez D, Wang JD.   +13 more
europepmc   +1 more source

The Stimulation of the Mitochondrial Uncoupler-Dependent ATPase in Isolated Hepatocytes by Catecholamines and Glucagon and Its Relationship to Gluconeogenesis [PDF]

, 1979
M A Titheradge, Janet L. Stringer, Robert C. Haynes   +2 more
openalex   +1 more source

Rapid and Effective Neuronal Conversion of Human Glioblastoma In Vitro and In Vivo Using Potent Small Molecules

Cell Proliferation, EarlyView.
A potent combination of small molecules YFSS (Y27632, Forskolin, SB431542, SP600125) that were screened through a neuronal‐specific promoter–reporter system TUBB3::mCherry effectively induces neuronal‐GBM conversion in vitro and in vivo, unveiling molecular mechanisms that offer a theoretical basis and a potential therapeutic strategy for treating GBM.
Ya'nan Hu, Jinming Liu, Jian Tu, Min Yang, Qisheng He, Fei Li, Xiaojing Xu, Zhongqing Ji, Jianwei Xu, Wentao Zhong, Mengwen Yan, Ying Yang, Huanxiang Zhang   +12 more
wiley   +1 more source

Non-catalytic mechanisms of KMT5C regulating hepatic gluconeogenesis. [PDF]

Nat Commun
Zhao Q, Cui X, Zhu Q, Li F, Bao R, Shi T, Liu H, Lv W, Xu Y, Gao Y, Tang QQ, Zhang M, Pan D.   +12 more
europepmc   +1 more source

Gluconeogenesis in the cow. The effects of a glucocorticoid on hepatic intermediary metabolism [PDF]

, 1970
G. D. Baird, R. J. Heitzman
openalex   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

Integration of transcriptomics and metabolomics data revealed role of insulin resistant SNW1 gene in the pathophysiology of gestational diabetes. [PDF]

Sci Rep
Bhushan R, Trivedi R, Raj R, Rani A, Rai S, Tripathi A, Rawat SG, Kumar A, Kumar D, Dubey PK.   +9 more
europepmc   +1 more source

Gluconeogenesis in the kidney cortex. Flow of malate between compartments [PDF]

, 1970
Robert Rognstad
openalex   +1 more source

Use of adjunctive glycaemic agents with vascular protective properties in individuals with type 1 diabetes: Potential benefits and risks

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Glycaemic therapy in type 1 diabetes (T1D) is focused on insulin, with the majority of studies investigating different insulin preparations, delivery devices and dosing accuracy methods. While insulin deficiency is the key mechanism for hyperglycaemia in T1D, individuals with this condition can also develop insulin resistance (IR), making ...
Ahmad M. Rajab, Sam Pearson, Ramzi A. Ajjan   +2 more
wiley   +1 more source