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Gluconeogenesis and the peroxisome

Molecular and Cellular Biochemistry, 1997
In this article, the capabilities of peroxisomal involvement in the gluconeogenetic processes of vertebrate animals are reviewed in the light of recent findings on peroxisomal metabolism and proliferation. It is demonstrated that the participation of this organelle affords the potential of alternative pathways for the conversion of triacylglycerols to ...
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Disorders of gluconeogenesis

Journal of Inherited Metabolic Disease, 1996
SummaryGluconeogenesis, or the formation of glucose from mainly lactate/pyruvate, glycerol and alanine, plays an essential role in the maintenance of normoglycaemia during fasting. Inborn deficiencies are known of each of the four enzymes of the glycolytic — gluconeogenic pathway that ensure a unidirectional flux from pyruvate to glucose: pyruvate ...
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Gluconeogenesis in Birds

Biochemical Society Transactions, 1978
It is a characteristic of all avian species that they maintain a plasma glucose concentration between 9 and 15 mM under all physiological circumstances. Even starvation for up to 9 days failed to lower the blood sugar concentration of chickens (Hazelwood & Lorenz, 1959).
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Regulation of gluconeogenesis by alanine

Biochimica et Biophysica Acta (BBA) - General Subjects, 1974
Abstract 1. 1. L -alanine and α-amino-isobutyric acid (0.5–10 mM) have been shown to stimulate glucose formation by isolated kidney tubules from fed and starved rats, with the substrates pyruvate, lactate, fructose, malate, fumarate, α-oxoglutarate and glycerol.
D, Friedrichs, W, Schoner
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Gluconeogenesis in the fetus and neonate

Seminars in Perinatology, 2000
Gluconeogenesis (GNG), a key metabolic process, involves the formation of glucose and glycogen from non-glucose precursors via pyruvate. In the strict sense, it also includes the contribution of glycerol as well as recycled glucose carbon (Cori's cycle).
S, Kalhan, P, Parimi
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Gluconeogenesis in vertebrate livers

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1977
1. The hypothesis is advanced that it would be logical for a tissue (liver) to evolve as a gluconeogenic organ in order to recover the lactate produced as a result of rapid and sustained contraction of skeletal muscle. 2. Lactate was present in skeletal muscle of all animals examined and increased following electrical stimulation.
J W, Phillips, F J, Hird
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Hepatic gluconeogenesis in chickens

Molecular and Cellular Biochemistry, 1978
Gluconeogenesis by isolated hepatocytes resulted in glucose release but insignificant rates of glycogen synthesis. The effectiveness of precursors was similar for hepatocytes from fed and starved chickens except for impaired gluconeogenesis from pyruvate when compared to lactate in lactate starved chicken hepatocytes.
A J, Dickson, D R, Langslow
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Hepatic gluconeogenesis of the rabbit

Biochemical and Biophysical Research Communications, 1970
Abstract Rabbit hepatic mitochondria (m W ), incubated with pyruvate and HCO 3 − produce and liberate to the media sizeable amounts of malate, citrate, and aspartate (if given NH 4 + ). M W from fasted or diabetic rabbits produce and liberate larger amounts of malate. Even though rabbit liver m W possess phosphoenolpyruvate carboxykinase(PEPCK),
D C, Johnson, K A, Ebert, P D, Ray
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Gluconeogenesis by the Human Kidney

Nature, 1966
GLUCONEOGENESIS has been demonstrated in slices of renal cortex removed from rats fed on ammonium chloride, whereas rats fed on sodium bicarbonate showed a marked reduction in renal glucose production1. Gluconeogenesis by the rat kidney is closely related to the hydrogen ion concentration of the incubation media and it occurs in the presence of a ...
G M, Aber, L O, Morris, E, Housley
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Gluconeogenesis and Redox State

1971
Summary It has been known for some time that the redox state of the NAD-couple in the liver, as measured by the [lactate]/[pyruvate] ratio, moves in the direction of reduction when the rate of gluconeogenesis increases. It was not evident however whether the redox state is of regulatory importance; in other words, whether the change in the redox ...
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