Results 11 to 20 of about 162,740 (383)
Excessive gluconeogenesis causes the hepatic insulin resistance paradox and its sequelae
Heliyon, 2022 Background: Hepatic insulin signaling suppresses gluconeogenesis but promotes de novo lipid synthesis. Paradoxically, hepatic insulin resistance (HIR) enhances both gluconeogenesis and de novo lipid synthesis. Elucidation of the etiology of this paradox,
Arnold N. Onyango
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Recent advances of long non-coding RNAs in control of hepatic gluconeogenesis
Frontiers in Endocrinology, 2023 Gluconeogenesis is the main process for endogenous glucose production during prolonged fasting, or certain pathological conditions, which occurs primarily in the liver.
Zhe Wang +4 more
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The molecular mechanism of propionate-regulating gluconeogenesis in bovine hepatocytes [PDF]
Animal Bioscience, 2023 Objective Cows that are nursing get around 80% of their glucose from liver gluconeogenesis. Propionate, a significant precursor of liver gluconeogenesis, can regulate the key genes involved in hepatic gluconeogenesis expression, but its precise effects ...
Rui Pang +7 more
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Molecular Metabolism, 2020 Objective: Salt-induced kinase 1 (SIK1) acts as a key modulator in many physiological processes. However, the effects of SIK1 on gluconeogenesis and the underlying mechanisms have not been fully elucidated. In this study, we found that a natural compound
Siwen Liu +6 more
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Identification and Functional Characterization of Arabidopsis icl Mutant Under Trehalose Feeding in Light and Dark Conditions [PDF]
Journal of Genetic Resources, 2019 Trehalose is a non-reducing sugar that plays an important role in plant growth and development. To study the role of trehalose on lipid metabolism and gluconeogenesis, Arabidopsis thaliana wild type (WT) and TreF (a line expressing trehalase) were grown ...
Aniseh Noroozipoor +2 more
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FAM3D inhibits gluconeogenesis in high glucose environment via DUSP1/ZFP36/SIK1 axis
Kaohsiung Journal of Medical Sciences, 2023 Hyperglycemia is the most important factor leading to the complications of type 2 diabetes mellitus (T2DM). The primary condition for the treatment of T2DM is to change the glucose and lipid metabolism disorders in the liver and other insulin‐sensitive ...
Bin Huang +5 more
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Frontiers in Pharmacology, 2021 Hengshun aromatic vinegar (HSAV), produced by typical solid-state or liquid-state fermentation techniques, is consumed worldwide as a food condiment.
Guoquan Li +9 more
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Glucagon stimulates gluconeogenesis by InsP3R-I mediated hepatic lipolysis
Nature, 2020 Although it is well-established that reductions in the ratio of insulin to glucagon in the portal vein have a major role in the dysregulation of hepatic glucose metabolism in type-2 diabetes 1 – 3 , the mechanisms by which glucagon affects hepatic ...
R. Perry +19 more
semanticscholar +1 more source
FEMS Yeast Research, 2002 According to different metabolic situations in various stages of Candida albicans pathogenesis the regulation of carbohydrate metabolism was investigated. We report the genetic characterization of all major C. albicans gluconeogenic and glyoxylate cycle genes (fructose-1,6-bisphosphatase, PEP carboxykinase, malate synthase and isocitrate lyase) which ...
K.-D. Entian, P. Kötter, D. Eschrich
openaire +3 more sources
The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective
International Journal of Molecular Sciences, 2020 Metformin therapy lowers blood glucose in type 2 diabetes by targeting various pathways including hepatic gluconeogenesis. Despite widespread clinical use of metformin the molecular mechanisms by which it inhibits gluconeogenesis either acutely through ...
L. Agius, Brian E. Ford, S. Chachra
semanticscholar +1 more source