Results 11 to 20 of about 74,459 (251)
Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Combining ligand‐based and structure‐based methodologies, the applied virtual screening approach identified a collection of sulfonamides targeting the human carbonic anhydrase (hCA) VA isoform. 2‐(3,4‐Dihydro‐2H‐quinolin‐1‐yl)‐N‐(4‐sulfamoylphenyl)acetamide was identified as a potent and selective lead compound as a candidate for further exploitation ...
Laura De Luca +4 more
wiley +1 more source
Unraveling the Regulation of Hepatic Gluconeogenesis
Frontiers in Endocrinology, 2019 Hepatic gluconeogenesis, de novo glucose synthesis from available precursors, plays a crucial role in maintaining glucose homeostasis to meet energy demands during prolonged starvation in animals.
Xueping Zhang +3 more
doaj +1 more source
Intestinal gluconeogenesis and glucose transport according to body fuel availability in rats [PDF]
J Physiol 566 (15/07/2005) 575-86, 2007 Intestinal hexose absorption and gluconeogenesis have been studied in relation to refeeding after two different fasting phases: a long period of protein sparing during which energy expenditure is derived from lipid oxidation (phase II), and a later phase characterized by a rise in plasma corticosterone triggering protein catabolism (phase III).
arxiv +1 more source
Lower glycolysis carries a higher flux than any biochemically possible alternative [PDF]
Nature Communications 6, 8427 (2015), 2014 The universality of many pathways of core metabolism suggests a strong role for evolutionary selection, but it remains unclear whether existing pathways have been selected from a large or small set of biochemical possibilities. To address this question, we construct "in silico" all possible biochemically feasible alternatives to the trunk pathway of ...
arxiv +1 more source
Medium‐chain Acyl‐COA dehydrogenase deficiency: Pathogenesis, diagnosis, and treatment
Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023 MCADD is a commonly inherited metabolic disease with serious implications for health outcomes, particularly in children, that may be successfully managed with proper intervention. In this review, we discuss the genetics, pathogenesis, clinical presentation, diagnosis, and treatments for Medium‐Chain Acyl‐CoA Dehydrogenase Deficiency (MCADD ...
Emily Mason +2 more
wiley +1 more source
Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023 Insulin resistance (IR) in adolescents with obesity is associated with a sex‐dependent metabolic “signature” comprising the branched‐chain amino acids (BCAAs), glutamate/glutamine, C3/C5 acylcarnitines, and uric acid. Here, we compared the levels of branched‐chain α‐keto acids (BCKAs) and glutamate/glutamine, which are byproducts of BCAA catabolism, as
Pinar Gumus Balikcioglu +8 more
wiley +1 more source
Limitations of the stochastic quasi-steady-state approximation in open biochemical reaction networks [PDF]
Journal of Chemical Physics 135, 181103 (2011), 2011 The application of the quasi-steady-state approximation to the Michaelis-Menten reaction embedded in large open chemical reaction networks is a popular model reduction technique in deterministic and stochastic simulations of biochemical reactions inside cells.
arxiv +1 more source
daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival
eLife, 2017 daf-16/FoxO is required to survive starvation in Caenorhabditis elegans, but how daf-16IFoxO promotes starvation resistance is unclear. We show that daf-16/FoxO restructures carbohydrate metabolism by driving carbon flux through the glyoxylate shunt and ...
Jonathan D Hibshman +9 more
doaj +1 more source
Cells, 2023 Nanomaterials offer a broad spectrum of applications in biomedicine. The shapes of gold nanoparticles could modulate tumor cell behavior. Spherical (AuNPsp), stars (AuNPst) and rods (AuNPr) shapes of polyethylene glycol coated-gold nanoparticles (AuNPs ...
Sílvia Soares +7 more
doaj +1 more source
Impact of Salmonella genome rearrangement on gene expression
Evolution Letters, Volume 6, Issue 6, Page 426-437, December 2022., 2022 Abstract In addition to nucleotide variation, many bacteria also undergo changes at a much larger scale via rearrangement of their genome structure (GS) around long repeat sequences. These rearrangements result in genome fragments shifting position and/or orientation in the genome without necessarily affecting the underlying nucleotide sequence.
Emma V. Waters +4 more
wiley +1 more source