Results 21 to 30 of about 196,582 (195)

Impacts of protein supplementation during late gestation of beef cows on maternal skeletal muscle and liver tissues metabolism

Animal, 2020
Since nutritional requirements are increased at the end of gestation to meet the demands of the pregnant uterus, pregnant beef cows are susceptible to mobilization of body reserves (mainly fat and amino acids (AAs)) and to alter the metabolism of ...
R.C. Lopes, C.B. Sampaio, A.S. Trece, P.D. Teixeira, T.R.S. Gionbelli, L.R. Santos, T.C. Costa, M.S. Duarte, M.P. Gionbelli   +8 more
doaj   +1 more source

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver [PDF]

, 2014
LKB1 is a master kinase that regulates metabolism and growth through adenosine monophosphate-activated protein kinase (AMPK) and 12 other closely related kinases. Liver-specific ablation of LKB1 causes increased glucose production in hepatocytes in vitro
Gray, NS, Kaestner, Klaus H., Gray, Nathanael, Birnbaum, Morris J., Campbell, David G, Kaestner, KH, Wan, Min, Sakamoto, Kei, Gray, Nathanael S., Gray, Nathanael S, Göransson, Olga, Sutherland, C, Gourlay, R, Titchenell, Paul, Sutherland, Calum, Patel, Kashyap, Marion, Allison, Viollet, B, Foretz, Marc, Titchenell, P, Sutherland, Calum; id_orcid, Göransson, Olga,, Birnbaum, Morris J, Campbell, David G., Patel, K, Foretz, M, Deak, M, Gourlay, Robert, Göransson, O, Deak, Maria, Viollet, Benoit, Marion, A, Wan, M, Birnbaum, MJ, Tournier, Emilie, Campbell, DG, Peggie, Mark, Boudaba, Nadia, Kaestner, Klaus H, Sakamoto, K, Tournier, E, Peggie, M, Lund University., Boudaba, N   +43 more
core   +1 more source

Disruption of pyruvate phosphate dikinase in Brucella ovis PA CO2-dependent and independent strains generates attenuation in the mouse model

Veterinary Research, 2020
Brucella ovis is a non-zoonotic rough Brucella that causes genital lesions, abortions and increased perinatal mortality in sheep and is responsible for important economic losses worldwide. Research on virulence factors of B.
Nieves Vizcaíno, Lara Pérez-Etayo, Raquel Conde-Álvarez, Maite Iriarte, Ignacio Moriyón, Amaia Zúñiga-Ripa   +5 more
doaj   +1 more source

Against the stream: relevance of gluconeogenesis from fatty acids for natives of the arctic regions [PDF]

International Journal of Circumpolar Health, 2012
Background. The question whether even-chain fatty acids can be converted into glucose has a long-standing tradition in biochemistry. Since the glyoxylate shunt is absent from mammals, the question has been considered to be solved.
Stefan Schuster, Luís F. de Figueiredo, Christoph Kaleta   +2 more
doaj   +1 more source

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α : modulation by p38 MAPK [PDF]

, 2004
The transcriptional coactivator PPAR gamma coactivator 1 α (PGC-1α) is a key regulator of metabolic processes such as mitochondrial biogenesis and respiration in muscle and gluconeogenesis in liver. Reduced levels of PGC-1α in humans have been associated
Lin, J., Jaeger, S., Tempst, P., Puigserver, P., Fan, M., Handschin, C., St-Pierre, J., Spiegelman, B. M., Rhee, J., Erdjument-Bromage, H.   +9 more
core   +1 more source

Pea protein hydrolysate reduces blood glucose in high-fat diet and streptozotocin-induced diabetic mice

Frontiers in Nutrition, 2023
IntroductionFood proteins have been recognized as an ideal source to release bioactive peptides with the potential to intervene nutrition related chronic diseases, such as cardiovascular diseases, obesity and diabetes.
Wang Liao, Xinyi Cao, Hui Xia, Shaokang Wang, Liang Chen, Guiju Sun   +5 more
doaj   +1 more source

Mutational analysis of fructose-1,6-bis-phosphatase FBP1 indicates partially independent functions in gluconeogenesis and sensitivity to genotoxic stress [PDF]

, 2017
Fructose-1,6-bisphosphatase (FBP1) is a key enzyme in the evolutionary conserved pathway of gluconeogenesis. We had shown in an earlier study that FBP1 is involved in the response and sensitivity to methyl-methanesulfonate (MMS)-induced DNA damage in ...
Ana Kitanovic, Jinda Holzwarth, Ali Ghanem, Stefan Wölfl, Ali Ghanem   +4 more
core   +1 more source

Molecular mechanisms of insulin resistance in chronic liver disease [PDF]

, 2008
The work presented here analyses the role of PP2A in the dysregulation of glucose metabolism in the setting of chronic hepatitis C. We propose a new model for virus induced insulin resistance development through the overexpression of PP2A in the liver ...
Bernsmeier, Christine
core   +1 more source

Mechanisms of transcriptional control of glucose metabolism in hepatocytes

Сахарный диабет, 2016
The hepatic tissue plays a key role in the regulation and maintenance of stable blood glucose levels. The liver is the main gluconeogenesis organ of the body and is under constant hormonal control to determine the metabolic activity of hepatocytes ...
Konstantin Y. Kulebyakin, Zhanna A. Akopyan, Tatiana N. Kochegura, Dmitry N. Penkov   +3 more
doaj   +1 more source

In Vivo Estimates of Liver Metabolic Flux Assessed by 13C-Propionate and 13C-Lactate Are Impacted by Tracer Recycling and Equilibrium Assumptions

Cell Reports, 2020
Summary: Isotope-based assessment of metabolic flux is achieved through a judicious balance of measurements and assumptions. Recent publications debate the validity of key assumptions used to model stable isotope labeling of liver metabolism in vivo ...
Clinton M. Hasenour, Mohsin Rahim, Jamey D. Young   +2 more
doaj   +1 more source