Results 21 to 30 of about 134,956 (333)

Endogenous Nutritive Support after Traumatic Brain Injury: Peripheral Lactate Production for Glucose Supply via Gluconeogenesis. [PDF]

, 2015
We evaluated the hypothesis that nutritive needs of injured brains are supported by large and coordinated increases in lactate shuttling throughout the body.
Brooks, George A, Glenn, Thomas C, Horning, Michael A, Hovda, David A, Johnson, Matthew L, Martin, Neil A, McArthur, David L, Vespa, Paul   +7 more
core   +1 more source

Stanniocalcin 1 effects on the renal gluconeogenesis pathway in rat and fish [PDF]

, 2015
The mammalian kidney contributes significantly to glucose homeostasis through gluconeogenesis. Considering that stanniocalcin 1 (STC1) regulates ATP production, is synthesized and acts in different cell types of the nephron, the present study ...
Abu Hossain, Adelino V.M. Canario, Basini, Bouras, Bradford, Chakravarty, Conjard, Curthoys, De Niu, De Niu, Deborah M. Power, Deol, Ellard, Filvaroff, Gerich, Goorno, Goto, Groisillier, Guder, Haddad, Huang, Ip, Isabel Morgado, Jahn, James, Kirchner, Knox, Krebs, Krebs, Kurokawa, Law, Law, Lu, Luiz C. Kucharski, Maleque, Marsenic, Mather, McCudden, Migliorini, Mitrakou, Mommsen, Monteil, Moreau, Munoz, Nagata, Nissim, Oliveira, Oliveira, Ookata, Pedro M.G. Guerreiro, Rasmussen, Rasmussen, Roselis S.M. da Silva, Sazonova, Schein, Schmittgen, Schoolwerth, She, Stark, Stark, Stasko, Stasko, Suarez, Tamura, Taylor, Tiago Leal Martins, Tocher, Tohmiya, Turner, Van Waarde, Vanessa Schein, Varghese, Wagner, Wagner, Walton, Walton, Wang, Westberg, Wong, Yang, Yeung   +80 more
core   +1 more source

daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival

eLife, 2017
daf-16/FoxO is required to survive starvation in Caenorhabditis elegans, but how daf-16IFoxO promotes starvation resistance is unclear. We show that daf-16/FoxO restructures carbohydrate metabolism by driving carbon flux through the glyoxylate shunt and ...
Jonathan D Hibshman, Alexander E Doan, Brad T Moore, Rebecca EW Kaplan, Anthony Hung, Amy K Webster, Dhaval P Bhatt, Rojin Chitrakar, Matthew D Hirschey, L Ryan Baugh   +9 more
doaj   +1 more source

Metabolic Disruption of Gold Nanospheres, Nanostars and Nanorods in Human Metastatic Prostate Cancer Cells

Cells, 2023
Nanomaterials offer a broad spectrum of applications in biomedicine. The shapes of gold nanoparticles could modulate tumor cell behavior. Spherical (AuNPsp), stars (AuNPst) and rods (AuNPr) shapes of polyethylene glycol coated-gold nanoparticles (AuNPs ...
Sílvia Soares, Cláudia Pereira, André P. Sousa, Ana Catarina Oliveira, Maria Goreti Sales, Miguel A. Correa-Duarte, Susana G. Guerreiro, Rúben Fernandes   +7 more
doaj   +1 more source

Adiponectin Deficiency Impairs Maternal Metabolic Adaptation to Pregnancy in Mice. [PDF]

, 2017
Hypoadiponectinemia has been widely observed in patients with gestational diabetes mellitus (GDM). To investigate the causal role of hypoadiponectinemia in GDM, adiponectin gene knockout (Adipoq-/- ) and wild-type (WT) mice were crossed to produce ...
Hay, William W, Lee, Samuel, Nguyen, Amanda, Qiao, Liping, Schaack, Jerome, Shao, Jianhua, Wattez, Jean-Sebastien   +6 more
core   +1 more source

Excessive gluconeogenesis causes the hepatic insulin resistance paradox and its sequelae

Heliyon, 2022
Background: Hepatic insulin signaling suppresses gluconeogenesis but promotes de novo lipid synthesis. Paradoxically, hepatic insulin resistance (HIR) enhances both gluconeogenesis and de novo lipid synthesis. Elucidation of the etiology of this paradox,
Arnold N. Onyango
doaj  

Against the stream: relevance of gluconeogenesis from fatty acids for natives of the arctic regions [PDF]

International Journal of Circumpolar Health, 2012
Background. The question whether even-chain fatty acids can be converted into glucose has a long-standing tradition in biochemistry. Since the glyoxylate shunt is absent from mammals, the question has been considered to be solved.
Stefan Schuster, Luís F. de Figueiredo, Christoph Kaleta   +2 more
doaj   +1 more source

Serum Metabolomic Profiles in Critically Ill Patients with Shock on Admission to the Intensive Care Unit

Metabolites, 2023
Inflammatory processes are common in intensive care (ICU) patients and can induce multiple changes in metabolism, leading to increased risks of morbidity and mortality.
Aurélie Thooft, Raphaël Conotte, Jean-Marie Colet, Karim Zouaoui Boudjeltia, Patrick Biston, Michaël Piagnerelli   +5 more
doaj   +1 more source

Lactate: brain fuel in human traumatic brain injury: a comparison with normal healthy control subjects. [PDF]

, 2015
We evaluated the hypothesis that lactate shuttling helps support the nutritive needs of injured brains. To that end, we utilized dual isotope tracer [6,6-(2)H2]glucose, that is, D2-glucose, and [3-(13)C]lactate techniques involving arm vein tracer ...
Brooks, George A, Glenn, Thomas C, Horning, Michael A, Hovda, David A, Martin, Neil A, McArthur, David L, Vespa, Paul   +6 more
core   +1 more source

Regulation by Dietary Carbohydrates of Intermediary Metabolism in Liver and Muscle of Two Isogenic Lines of Rainbow Trout

Frontiers in Physiology, 2018
Rainbow trout (Oncorhynchus mykiss) is recognized as a typical “glucose-intolerant” fish, and the limits of dietary carbohydrate utilization have been investigated for many years.
Xuerong Song, Xuerong Song, Xuerong Song, Lucie Marandel, Sandrine Skiba-Cassy, Geneviève Corraze, Mathilde Dupont-Nivet, Edwige Quillet, Inge Geurden, Stephane Panserat   +9 more
doaj   +1 more source