Results 21 to 30 of about 74,459 (251)

Excessive gluconeogenesis causes the hepatic insulin resistance paradox and its sequelae

Heliyon, 2022
Background: Hepatic insulin signaling suppresses gluconeogenesis but promotes de novo lipid synthesis. Paradoxically, hepatic insulin resistance (HIR) enhances both gluconeogenesis and de novo lipid synthesis. Elucidation of the etiology of this paradox,
Arnold N. Onyango
doaj  

Against the stream: relevance of gluconeogenesis from fatty acids for natives of the arctic regions [PDF]

International Journal of Circumpolar Health, 2012
Background. The question whether even-chain fatty acids can be converted into glucose has a long-standing tradition in biochemistry. Since the glyoxylate shunt is absent from mammals, the question has been considered to be solved.
Stefan Schuster, Luís F. de Figueiredo, Christoph Kaleta   +2 more
doaj   +1 more source

Serum Metabolomic Profiles in Critically Ill Patients with Shock on Admission to the Intensive Care Unit

Metabolites, 2023
Inflammatory processes are common in intensive care (ICU) patients and can induce multiple changes in metabolism, leading to increased risks of morbidity and mortality.
Aurélie Thooft, Raphaël Conotte, Jean-Marie Colet, Karim Zouaoui Boudjeltia, Patrick Biston, Michaël Piagnerelli   +5 more
doaj   +1 more source

Regulation by Dietary Carbohydrates of Intermediary Metabolism in Liver and Muscle of Two Isogenic Lines of Rainbow Trout

Frontiers in Physiology, 2018
Rainbow trout (Oncorhynchus mykiss) is recognized as a typical “glucose-intolerant” fish, and the limits of dietary carbohydrate utilization have been investigated for many years.
Xuerong Song, Xuerong Song, Xuerong Song, Lucie Marandel, Sandrine Skiba-Cassy, Geneviève Corraze, Mathilde Dupont-Nivet, Edwige Quillet, Inge Geurden, Stephane Panserat   +9 more
doaj   +1 more source

Glucagon Promotes Gluconeogenesis through the GCGR/PKA/CREB/PGC-1α Pathway in Hepatocytes of the Japanese Flounder Paralichthys olivaceus

Cells, 2023
In order to investigate the mechanism of glucagon regulation of gluconeogenesis, primary hepatocytes of the Japanese flounder (Paralichthys olivaceus) were incubated with synthesized glucagon, and methods based on inhibitors and gene overexpression were ...
Mengxi Yang, Mingzhu Pan, Dong Huang, Jiahuan Liu, Yanlin Guo, Yue Liu, Wenbing Zhang   +6 more
doaj   +1 more source

Disruption of pyruvate phosphate dikinase in Brucella ovis PA CO2-dependent and independent strains generates attenuation in the mouse model

Veterinary Research, 2020
Brucella ovis is a non-zoonotic rough Brucella that causes genital lesions, abortions and increased perinatal mortality in sheep and is responsible for important economic losses worldwide. Research on virulence factors of B.
Nieves Vizcaíno, Lara Pérez-Etayo, Raquel Conde-Álvarez, Maite Iriarte, Ignacio Moriyón, Amaia Zúñiga-Ripa   +5 more
doaj   +1 more source

The mechanistic target of rapamycin complex 1 pathway involved in hepatic gluconeogenesis through peroxisome-proliferator-activated receptor γ coactivator-1α

Animal Nutrition, 2022
Cattle can efficiently perform de novo generation of glucose through hepatic gluconeogenesis to meet post-weaning glucose demand. Substantial evidence points to cattle and non-ruminant animals being characterized by phylogenetic features in terms of ...
Guoyan Wang, Jun Zhang, Shengru Wu, Senlin Qin, Yining Zheng, Chao Xia, Huijun Geng, Junhu Yao, Lu Deng   +8 more
doaj  

FAM3D inhibits gluconeogenesis in high glucose environment via DUSP1/ZFP36/SIK1 axis

Kaohsiung Journal of Medical Sciences, 2023
Hyperglycemia is the most important factor leading to the complications of type 2 diabetes mellitus (T2DM). The primary condition for the treatment of T2DM is to change the glucose and lipid metabolism disorders in the liver and other insulin‐sensitive ...
Bin Huang, Yue‐Ling Luo, Jun‐Ling Huang, Guang‐Zhi Li, Shi‐Yuan Qiu, Chun‐Chun Huang   +5 more
doaj   +1 more source

Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway

Molecular Metabolism, 2020
Objective: Salt-induced kinase 1 (SIK1) acts as a key modulator in many physiological processes. However, the effects of SIK1 on gluconeogenesis and the underlying mechanisms have not been fully elucidated. In this study, we found that a natural compound
Siwen Liu, Suling Huang, Xingde Wu, Ying Feng, Yu Shen, Qin-shi Zhao, Ying Leng   +6 more
doaj  

Possible evidence of gluconeogenesis in Plasmodium- Infected children in relationship with the parasite density

Biomedical and Biotechnology Research Journal, 2020
Background: Gluconeogenesis is stimulated by low blood glucose to maintain the glucose level; it involves lipolysis (breaking down of triglycerides), release of cortisol, and production of glycerol which can be converted into glucose.
Mathew Folaranmi Olaniyan, Tolulope Busayo Ojediran, Shedarck Gbenga Olayinka   +2 more
doaj   +1 more source