Results 21 to 30 of about 226,966 (285)

Adiponectin Deficiency Impairs Maternal Metabolic Adaptation to Pregnancy in Mice. [PDF]

, 2017
Hypoadiponectinemia has been widely observed in patients with gestational diabetes mellitus (GDM). To investigate the causal role of hypoadiponectinemia in GDM, adiponectin gene knockout (Adipoq-/- ) and wild-type (WT) mice were crossed to produce ...
Hay, William W, Lee, Samuel, Nguyen, Amanda, Qiao, Liping, Schaack, Jerome, Shao, Jianhua, Wattez, Jean-Sebastien   +6 more
core   +1 more source

Disruption of pyruvate phosphate dikinase in Brucella ovis PA CO2-dependent and independent strains generates attenuation in the mouse model

Veterinary Research, 2020
Brucella ovis is a non-zoonotic rough Brucella that causes genital lesions, abortions and increased perinatal mortality in sheep and is responsible for important economic losses worldwide. Research on virulence factors of B.
Nieves Vizcaíno, Lara Pérez-Etayo, Raquel Conde-Álvarez, Maite Iriarte, Ignacio Moriyón, Amaia Zúñiga-Ripa   +5 more
doaj   +1 more source

Against the stream: relevance of gluconeogenesis from fatty acids for natives of the arctic regions [PDF]

International Journal of Circumpolar Health, 2012
Background. The question whether even-chain fatty acids can be converted into glucose has a long-standing tradition in biochemistry. Since the glyoxylate shunt is absent from mammals, the question has been considered to be solved.
Stefan Schuster, Luís F. de Figueiredo, Christoph Kaleta   +2 more
doaj   +1 more source

Pea protein hydrolysate reduces blood glucose in high-fat diet and streptozotocin-induced diabetic mice

Frontiers in Nutrition, 2023
IntroductionFood proteins have been recognized as an ideal source to release bioactive peptides with the potential to intervene nutrition related chronic diseases, such as cardiovascular diseases, obesity and diabetes.
Wang Liao, Xinyi Cao, Hui Xia, Shaokang Wang, Liang Chen, Guiju Sun   +5 more
doaj   +1 more source

A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. [PDF]

, 2015
The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute
Ahmadian, Maryam, Chang, Louise, Downes, Michael, Evans, Ronald M, Korytnaya, Evgenia, Krause, Danielle M, Liddle, Christopher, Lumeng, Carey N, Neidert, Adam, Oral, Elif A, Peng, Xiaoling, Poirier, BreAnne, Reilly, Shannon M, Saltiel, Alan R, Uhm, Maeran, Yu, Ruth T, Zamarron, Brian F   +16 more
core   +2 more sources

Mechanisms of transcriptional control of glucose metabolism in hepatocytes

Сахарный диабет, 2016
The hepatic tissue plays a key role in the regulation and maintenance of stable blood glucose levels. The liver is the main gluconeogenesis organ of the body and is under constant hormonal control to determine the metabolic activity of hepatocytes ...
Konstantin Y. Kulebyakin, Zhanna A. Akopyan, Tatiana N. Kochegura, Dmitry N. Penkov   +3 more
doaj   +1 more source

Transcriptional Regulator TonEBP Mediates Oxidative Damages in Ischemic Kidney Injury [PDF]

, 2019
TonEBP (tonicity-responsive enhancer binding protein) is a transcriptional regulator whose expression is elevated in response to various forms of stress including hyperglycemia, inflammation, and hypoxia.
Choi, Soo Youn, Kang, Hyun Je, Kwon, Hyug Moo, Kwon, Mi Jin, Lee-Kwon, Whaseon, Lim, Sun Woo, Nam, Dougu, Park, Hyun, Sanada, Satoru, Yoo, Eun Jin, Yoon, Sora   +10 more
core   +1 more source

Renal Gluconeogenesis [PDF]

Diabetes Care, 2001
Studies conducted over the last 60 years in animals and in vitro have provided considerable evidence that the mammalian kidney can make glucose and release it under various conditions. Until quite recently, however, it was generally believed that the human kidney was not an important source of glucose except during acidosis and after prolonged fasting.
John E. Gerich, Christian Meyer, Hans J. Woerle, Michael Stumvoll   +3 more
openaire   +1 more source

Stanniocalcin 1 effects on the renal gluconeogenesis pathway in rat and fish [PDF]

, 2015
The mammalian kidney contributes significantly to glucose homeostasis through gluconeogenesis. Considering that stanniocalcin 1 (STC1) regulates ATP production, is synthesized and acts in different cell types of the nephron, the present study ...
Abu Hossain, Adelino V.M. Canario, Basini, Bouras, Bradford, Chakravarty, Conjard, Curthoys, De Niu, De Niu, Deborah M. Power, Deol, Ellard, Filvaroff, Gerich, Goorno, Goto, Groisillier, Guder, Haddad, Huang, Ip, Isabel Morgado, Jahn, James, Kirchner, Knox, Krebs, Krebs, Kurokawa, Law, Law, Lu, Luiz C. Kucharski, Maleque, Marsenic, Mather, McCudden, Migliorini, Mitrakou, Mommsen, Monteil, Moreau, Munoz, Nagata, Nissim, Oliveira, Oliveira, Ookata, Pedro M.G. Guerreiro, Rasmussen, Rasmussen, Roselis S.M. da Silva, Sazonova, Schein, Schmittgen, Schoolwerth, She, Stark, Stark, Stasko, Stasko, Suarez, Tamura, Taylor, Tiago Leal Martins, Tocher, Tohmiya, Turner, Van Waarde, Vanessa Schein, Varghese, Wagner, Wagner, Walton, Walton, Wang, Westberg, Wong, Yang, Yeung   +80 more
core   +1 more source

In Vivo Estimates of Liver Metabolic Flux Assessed by 13C-Propionate and 13C-Lactate Are Impacted by Tracer Recycling and Equilibrium Assumptions

Cell Reports, 2020
Summary: Isotope-based assessment of metabolic flux is achieved through a judicious balance of measurements and assumptions. Recent publications debate the validity of key assumptions used to model stable isotope labeling of liver metabolism in vivo ...
Clinton M. Hasenour, Mohsin Rahim, Jamey D. Young   +2 more
doaj   +1 more source