Results 41 to 50 of about 134,956 (333)

Inhibitors of Pyruvate Carboxylase [PDF]

, 2010
This review aims to discuss the varied types of inhibitors of biotin-dependent carboxylases, with an emphasis on the inhibitors of pyruvate carboxylase.
Attwood, Paul V., Maurice, Martin St., Zeczycki, Tonya N.   +2 more
core   +2 more sources

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Sex Dependent Dysregulation of Hepatic Glucose Production in Lean Type 2 Diabetic Rats

Frontiers in Endocrinology, 2019
We have characterized a lean type 2 diabetic rat model by gestational low protein programming. We aimed to identify if the regulation of hepatic glucose production (HGP) via gluconeogenesis and glycogenolysis is affected and if there are any sex ...
Chellakkan S. Blesson, Amy Schutt, Shaji Chacko, Juan C. Marini, Juan C. Marini, Pretty Rose Mathew, Daren Tanchico, Meena Balakrishnan, Chandra Yallampalli   +8 more
doaj   +1 more source

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review [PDF]

, 2020
Background A growing number of epidemiological studies indicate that metabolic syndrome (MetS) and its associated features play a key role in the development of certain degenerative brain disorders, including Alzheimer’s disease and vascular dementia ...
Bell, J.D., Bell, J.D., Bligh, S.W.A., Bligh, S.W.A., Katsuno, T., Katsuno, T., Parkinson, J., Parkinson, J., Shinjyo, N., Shinjyo, N.   +9 more
core   +1 more source

The bloodstream form of Trypanosoma brucei displays non-canonical gluconeogenesis.

PLoS Neglected Tropical Diseases
Trypanosoma brucei is a causative agent of the Human and Animal African Trypanosomiases. The mammalian stage parasites infect various tissues and organs including the bloodstream, central nervous system, skin, adipose tissue and lungs.
Julie Kovářová, Martin Moos, Michael P Barrett, David Horn, Alena Zíková   +4 more
doaj   +1 more source

The Influence of Ca2+ on Gluconeogenesis Stimulation by Glucagon in the Liver of Arthritic Rats

Brazilian Archives of Biology and Technology, 2002
Ca2+ participates in the stimulation of hepatic gluconeogenesis by glucagon and there is evidence that Ca2+ fluxes are modified in arthritic rats. These findings raise the question whether hepatic gluconeogenesis in arthritic rats responds differently to
Ana M. Kelmer-Bracht, Zélio Fedatto-Júnior, Emy L. Ishii-Iwamoto, Silvana M. Caparroz-Assef, Adelar Bracht   +4 more
doaj   +1 more source

Gluconeogenesis in the eel. II. Gluconeogenesis in the alloxanized eel.

NIPPON SUISAN GAKKAISHI, 1975
Gluconeogenesis in eel with alloxan induced insulin deficiency was studied. A single injection of alloxan produced a marked hyperglycemia, glycosuria, and pronounced elevation of plasma amino nitrogen in eel, Liver glycogen decreased 3 days after the alloxan injection but increased after 10 days. There were, however, no appreciable changes in GOT, GPT,
Yasuo Inui, Motoyoshi Yokote
openaire   +2 more sources

Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. [PDF]

, 2015
Defective hepatic insulin receptor (IR) signalling is a pathogenic manifestation of metabolic disorders including obesity and diabetes. The endo/lysosomal trafficking system may coordinate insulin action and nutrient homeostasis by endocytosis of IR and ...
Burnol, Anne-Françoise, Guan, Kun-Liang, Montagnac, Guillaume, Morzyglod, Lucille, Nemazanyy, Ivan, Panasyuk, Ganna, Pende, Mario, Russell, Ryan C   +7 more
core   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration – A Mass Spectrometry Imaging Study of the Perfused Rat Liver

Frontiers in Pharmacology, 2018
Metformin is the first line drug for type 2 diabetes but its molecular mechanisms remain unclear. Here, we have studied the acute effect of a therapeutically relevant intrahepatic concentration of metformin on glucose production from lactate. We selected
Giulio Calza, Elisabeth Nyberg, Elisabeth Nyberg, Matias Mäkinen, Rabah Soliymani, Annunziata Cascone, Dan Lindholm, Dan Lindholm, Emanuele Barborini, Marc Baumann, Maciej Lalowski, Ove Eriksson   +11 more
doaj   +1 more source