Results 41 to 50 of about 162,740 (383)

Stanniocalcin 1 effects on the renal gluconeogenesis pathway in rat and fish [PDF]

, 2015
The mammalian kidney contributes significantly to glucose homeostasis through gluconeogenesis. Considering that stanniocalcin 1 (STC1) regulates ATP production, is synthesized and acts in different cell types of the nephron, the present study ...
Abu Hossain, Adelino V.M. Canario, Basini, Bouras, Bradford, Chakravarty, Conjard, Curthoys, De Niu, De Niu, Deborah M. Power, Deol, Ellard, Filvaroff, Gerich, Goorno, Goto, Groisillier, Guder, Haddad, Huang, Ip, Isabel Morgado, Jahn, James, Kirchner, Knox, Krebs, Krebs, Kurokawa, Law, Law, Lu, Luiz C. Kucharski, Maleque, Marsenic, Mather, McCudden, Migliorini, Mitrakou, Mommsen, Monteil, Moreau, Munoz, Nagata, Nissim, Oliveira, Oliveira, Ookata, Pedro M.G. Guerreiro, Rasmussen, Rasmussen, Roselis S.M. da Silva, Sazonova, Schein, Schmittgen, Schoolwerth, She, Stark, Stark, Stasko, Stasko, Suarez, Tamura, Taylor, Tiago Leal Martins, Tocher, Tohmiya, Turner, Van Waarde, Vanessa Schein, Varghese, Wagner, Wagner, Walton, Walton, Wang, Westberg, Wong, Yang, Yeung   +80 more
core   +1 more source

Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1

Diabetes, 2018
Premenopausal women exhibit enhanced insulin sensitivity and reduced incidence of type 2 diabetes (T2D) compared with age-matched men, but this advantage disappears after menopause with disrupted glucose homeostasis, in part owing to a reduction in ...
Hui Yan, Wangbao Yang, Fenghua Zhou, Xiaopeng Li, Quan Pan, Zheng Shen, G. Han, A. Newell-Fugate, Yanan Tian, R. Majeti, W. Liu, Yong Xu, Chaodong Wu, Kimberly Allred, Clinton D Allred, Yuxiang Sun, Shaodong Guo   +16 more
semanticscholar   +1 more source

daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival

eLife, 2017
daf-16/FoxO is required to survive starvation in Caenorhabditis elegans, but how daf-16IFoxO promotes starvation resistance is unclear. We show that daf-16/FoxO restructures carbohydrate metabolism by driving carbon flux through the glyoxylate shunt and ...
Jonathan D Hibshman, Alexander E Doan, Brad T Moore, Rebecca EW Kaplan, Anthony Hung, Amy K Webster, Dhaval P Bhatt, Rojin Chitrakar, Matthew D Hirschey, L Ryan Baugh   +9 more
doaj   +1 more source

Analogous Metabolic Decoupling in Pseudomonas putida and Comamonas testosteroni Implies Energetic Bypass to Facilitate Gluconeogenic Growth

mBio, 2021
Gluconeogenic carbon metabolism is not well understood, especially within the context of flux partitioning between energy generation and biomass production, despite the importance of gluconeogenic carbon substrates in natural and engineered carbon ...
Rebecca A. Wilkes, Jacob Waldbauer, Ludmilla Aristilde   +2 more
doaj   +1 more source

Tracking the carbons supplying gluconeogenesis

Journal of Biological Chemistry, 2020
As the burden of type 2 diabetes mellitus (T2DM) grows in the 21st century, the need to understand glucose metabolism heightens. Increased gluconeogenesis is a major contributor to the hyperglycemia seen in T2DM.
Ankit M. Shah, F. Wondisford
semanticscholar   +1 more source

Glucagon Promotes Gluconeogenesis through the GCGR/PKA/CREB/PGC-1α Pathway in Hepatocytes of the Japanese Flounder Paralichthys olivaceus

Cells, 2023
In order to investigate the mechanism of glucagon regulation of gluconeogenesis, primary hepatocytes of the Japanese flounder (Paralichthys olivaceus) were incubated with synthesized glucagon, and methods based on inhibitors and gene overexpression were ...
Mengxi Yang, Mingzhu Pan, Dong Huang, Jiahuan Liu, Yanlin Guo, Yue Liu, Wenbing Zhang   +6 more
doaj   +1 more source

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

Nature, 2014
Metformin is considered to be one of the most effective therapeutics for treating type 2 diabetes because it specifically reduces hepatic gluconeogenesis without increasing insulin secretion, inducing weight gain or posing a risk of hypoglycaemia.
A. Madiraju, D. Erion, Y. Rahimi, Xian‐Man Zhang, D. Braddock, R. Albright, Brett J. Prigaro, J. Wood, S. Bhanot, M. MacDonald, M. Jurczak, J. Camporez, Hui-Young Lee, G. Cline, V. Samuel, R. Kibbey, G. Shulman   +16 more
semanticscholar   +1 more source

The Hypoglycemic Effect of Berberine and Berberrubine Involves Modulation of Intestinal Farnesoid X Receptor Signaling Pathway and Inhibition of Hepatic Gluconeogenesis

Drug Metabolism And Disposition, 2020
Our previous study suggests that berberine (BBR) lowers lipids by modulating bile acids and activating intestinal farnesoid X receptor (FXR). However, to what extent this pathway contributes to the hypoglycemic effect of BBR has not been determined.
R. Sun, Bo Kong, Na Yang, B. Cao, D. Feng, Xiaoyi Yu, Chun Ge, Si-qi Feng, Fei Fei, Jing-qiu Huang, Zhenyao Lu, Yuan Xie, Chung S. Yang, G. Guo, Guangji Wang, Jiye Aa   +15 more
semanticscholar   +1 more source

Gluconeogenesis: An ancient biochemical pathway with a new twist

Fly, 2017
Synthesis of sugars from simple carbon sources is critical for survival of animals under limited nutrient availability. Thus, sugar-synthesizing enzymes should be present across the entire metazoan spectrum.
Tetsuya Miyamoto, Hubert Amrein
doaj   +1 more source

Regulation by Dietary Carbohydrates of Intermediary Metabolism in Liver and Muscle of Two Isogenic Lines of Rainbow Trout

Frontiers in Physiology, 2018
Rainbow trout (Oncorhynchus mykiss) is recognized as a typical “glucose-intolerant” fish, and the limits of dietary carbohydrate utilization have been investigated for many years.
Xuerong Song, Xuerong Song, Xuerong Song, Lucie Marandel, Sandrine Skiba-Cassy, Geneviève Corraze, Mathilde Dupont-Nivet, Edwige Quillet, Inge Geurden, Stephane Panserat   +9 more
doaj   +1 more source