Results 91 to 100 of about 298,051 (300)

Glucose-6-Phosphate Dehydrogenase in Human Skin

Journal of Investigative Dermatology, 1964
The detection of glucose-6-phosphate dehydrogenase (9) and of 6-phosphogluconate dehydrogenase (8) in human skin suggested the presence of the hexose monophosphate shunt pathway (HMP shunt), which previously had been shown to exist in rat skin (1). Further studies with glucose6C4 and glucose-i-C'4 in epidermal slices (5, 7) have confirmed this theory ...
Weber, G., Korting, G.W.
openaire   +2 more sources

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Glucose - 6 - phosphate dehydrogenase deficiency In a group of Iraqi children

مجلة كلية الطب, 2005
Background: Glucose -6- phosphate deosphate dehydnogenase (G6PD) deficiency is a common problem in Iraqi as well as in tropical A subtropical region. Aim of study: to study the epidemiological aspect of G6PD deftaiency among Iraqi children.
Sawsan S. Abbas
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle

, 2015
Cancer cells utilize large amounts of ATP to sustain growth, relying primarily on non-oxidative, fermentative pathways for its production. In many types of cancers this leads, even in the presence of oxygen, to the secretion of carbon equivalents ...
Capuani, Fabrizio, De Martino, Andrea, De Martino, Daniele, Marinari, Enzo   +3 more
core   +1 more source

Stable isotope profiles reveal active production of VOCs from human-associated microbes. [PDF]

, 2017
Volatile organic compounds (VOCs) measured from exhaled breath have great promise for the diagnosis of bacterial infections. However, determining human or microbial origin of VOCs detected in breath remains a great challenge.
Barletta, Barbara, Blake, Donald R, Meinardi, Simone, Phan, Joann, Whiteson, Katrine   +4 more
core   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency in Neonates Hospitalized in Pasteur Hospital of Bam, Iran

Medical Laboratory Journal, 2020
Background and Objectives: The pentose phosphate pathway is of particular importance for energy supply in red blood cells. Glucose 6-phosphate dehydrogenase is the key enzyme involved in this pathway.
mahtab nejadaria, Seyed mojtaba mortazavi, Mohammad Hasan Kohansal   +2 more
doaj  

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source