Results 51 to 60 of about 298,051 (300)

Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis [PDF]

, 2013
Previous models of glycolysis in the sleeping sickness parasite Trypanosoma brucei assumed that the core part of glycolysis in this unicellular parasite is tightly compartimentalized within an organelle, the glycosome, which had previously been shown to ...
Achcar, Albert, Bakker, Bakker, Bakker, Bakker, Blattner, Chevalier, Clarkson, Clarkson, Cronín, Fairlamb, Fairlamb, Gualdron-López, Gualdrón-López, Guerra-Giraldez, Haanstra, Haanstra, Hammond, Helfert, Häusler, Michels, Miškovíc, Murabito, Opperdoes, Rizk, Satish Kumar, Steiger, Tran, Visser, Wang   +30 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2006
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Y ZahedPasha, M Ahmad Pour, A ZahedPasha
doaj  

Evaluation of glucose-6-phosphate dehydrogenase activity and hematological changes in psychotic patients undergoing antipsychotic chemotherapy in Benin City

Sahel Medical Journal, 2018
Background: Drug-induced hemolytic anemia can be life threatening and may pose a threat to the management and disease progression of some illnesses.
Evarista Odaburhine Osime, Felicitas Ezinwanne Onuigbo, Stephen Chikaodiri Samuel   +2 more
doaj   +1 more source

Erythrocytes as Carriers of Therapeutic Enzymes. [PDF]

, 2020
Therapeutic enzymes are administered for the treatment of a wide variety of diseases. They exert their effects through binding with a high affinity and specificity to disease-causing substrates to catalyze their conversion to a non-noxious product, to ...
Bax, BE
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Molecular Characterization of Glucose-6-phosphate Dehydrogenase Deficiency in Oman

Oman Medical Journal, 2023
Objectives: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most encountered abnormality of red blood cell metabolism worldwide and has a high prevalence in Oman.
Ammar Al-Sheryani1, , Hajer Al-Gheithi, Muntadhar Al Moosawi, Shaoib Al-Zadjali, Yasser Wali, Murtadha Al-Khabori   +5 more
doaj   +1 more source

Biochemical polymorphisms in the Malaysian water buffaloes [PDF]

, 1980
Ten enzymes and proteins: transferrin, amylase, haemoglobin, esterase D, red cell acid pho.phatau, superoxide dismutase, phosphoglycolate phosphatase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and soluble glutamate oxaloace ...
Gan, Yik Yuen, Jainudeen, Mohamed Razeen, Tan, S. K., Tan, Soon Guan   +3 more
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Variation in Glucose-6-Phosphate Dehydrogenase activity following acute malaria.

PLoS Neglected Tropical Diseases, 2022
Primaquine and tafenoquine are the only licensed drugs with activity against Plasmodium vivax hypnozoites but cause haemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Benedikt Ley, Mohammad Shafiul Alam, Ari Winasti Satyagraha, Ching Swe Phru, Kamala Thriemer, Dagimawie Tadesse, Tamiru Shibiru, Asrat Hailu, Mohammad Golam Kibria, Mohammad Sharif Hossain, Hisni Rahmat, Jeanne R Poespoprodjo, Wasif Ali Khan, Julie A Simpson, Ric N Price   +14 more
doaj   +1 more source