Results 91 to 100 of about 64,860 (226)

Glycolytic metabolism of CD8+ T‐cells affects susceptibility to human leukocyte antigen‐mediated abacavir‐induced hypersensitivity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Drug hypersensitivity reactions (DHRs) associated with a specific human leukocyte antigen (HLA) allotype do not manifest uniformly in all individuals within an HLA model population. This scenario highlights the complexity of predicting drug hypersensitivity reaction risk without considering additional factors ...
Takeshi Susukida, Yuchen Sun, Noriaki Arakawa, Takuya Hirao, Tadahaya Mizuno, Shigeki Aoki, Kousei Ito, Yoshihiro Hayakawa   +7 more
wiley   +1 more source

Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle.

PLoS ONE, 2015
Cannabinoid CB1 receptors peripherally modulate energy metabolism. Here, we investigated the role of CB1 receptors in the expression of glucose/pyruvate/tricarboxylic acid (TCA) metabolism in rat abdominal muscle.
Sergio Arrabal, Miguel Angel Lucena, Miren Josune Canduela, Almudena Ramos-Uriarte, Patricia Rivera, Antonia Serrano, Francisco Javier Pavón, Juan Decara, Antonio Vargas, Elena Baixeras, Mercedes Martín-Rufián, Javier Márquez, Pedro Fernández-Llébrez, Baukje De Roos, Pedro Grandes, Fernando Rodríguez de Fonseca, Juan Suárez   +16 more
doaj   +1 more source

Phylogenetic multi-locus codon models and molecular clocks reveal the monophyly of haematophagous reduviid bugs and their evolution at the formation of South America.

, 2010
We previously constructed a single molecular clock to date insect evolution that remains a cornerstone within entomological dating. The insect clock predicts that triatomine bugs, the vectors of South American trypanosomiasis, originated with the ...
Gaunt, Michael W, Patterson, James S
core   +1 more source

The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy [PDF]

, 2013
The discovery of increased formation of methylglyoxal (MG) by cell metabolism in high glucose concentration in vitro suggested possible relevance to diabetes and diabetes complications (1,2).
Rabbani, Naila, Thornalley, Paul J.
core   +1 more source

Phycocyanobilin biosynthesis in Galdieria sulphuraria requires isomerization of phycoerythrobilin synthesized by bilin reductases

The FEBS Journal, EarlyView.
The biosynthesis of bilins, tetrapyrroles essential for light harvesting and sensing, is performed by specific enzymes (FDBRs). In Galdieria sulphuraria, both phycobiliprotein types bind phycocyanobilin, despite lacking the canonical synthesizing gene PCYA. Instead, PEBA and PEBB are encoded, producing phycoerythrobilin, proposed to be later isomerized
Federica Frascogna, Nathan C. Rockwell, Jana Hartmann, Julie M. Mudler, Nicole Frankenberg‐Dinkel   +4 more
wiley   +1 more source

6-BA Delays the Senescence of Postharvest Cabbage Leaves by Inhibiting Respiratory Metabolism

Foods
6-BA, a small molecule compound of cytokinins, has been proven to delay leaf senescence in different species, including Chinese flowering cabbage; however, its specific mechanism remains relatively unknown. In this study, the application of external 6-BA
Cimei Wang, Yingying Yang, Jieting Yu, Zongli Liu, Wei Wei, Jianye Chen, Jianhua Zhu, Riming Huang   +7 more
doaj   +1 more source

Analysis of a conserved cellulase transcriptional regulator reveals inducer-independent production of cellulolytic enzymes in Neurospora crassa. [PDF]

, 2013
Cellulose is recalcitrant to deconstruction to glucose for use in fermentation strategies for biofuels and chemicals derived from lignocellulose. In Neurospora crassa, the transcriptional regulator, CLR-2, is required for cellulolytic gene expression and
Coradetti, Samuel, Glass, N. Louise, Xiong, Yi   +2 more
core   +2 more sources

The GmGT‐2F, a trihelix transcription factor, regulates seed oil content by directly activating GmAGAL transcription in soybean

Journal of Integrative Plant Biology, EarlyView.
In soybean, the trihelix transcription factor GmGT‐2F positively regulates the expression of the α‐galactosidase gene GmAGAL, thereby modulating seed oil content. The cyclophilin GmCYP2 interacts with GmGT‐2F and suppresses GmAGAL activation. Haplotype diversity analysis of GmGT‐2F, GmCYP2, and GmAGAL identified favorable haplotype combinations ...
Shuangzhe Li, Yifan Cui, Yang Liu, Mingliang Yang, Xiaoxia Wu, Qingshan Chen, Ying Zhao   +6 more
wiley   +1 more source

Autocrine motility factor peptide enhances curcumin/tetrahydrocurcumin activity against colorectal cancer cells in association with glucose-6-phosphate dehydrogenase downregulation and oxidative stress

Applied Biological Chemistry
Current therapeutic approaches for colorectal cancer (CRC) face significant limitations, including drug resistance, adverse effects, and high costs.
Kyunghee Lee, Yuhan Cho, Dong-Won Bae, Kim-Ngan Thi Nguyen, Changyul Kim, Phil-Ok Koh, Hee Sung Park   +6 more
doaj   +1 more source

Draft Genome Sequence of Fructophilic Lactobacillus florum. [PDF]

, 2013
Herein we report the first genome sequence for Lactobacillus florum. L. florum 2F was isolated from Valencia orange leaves and is fructophilic, like other strains of this species. The draft genome of L.
Kim, Eun Bae, Kopit, Lauren M, Marco, Maria L, Tyler, Charlotte A   +3 more
core   +2 more sources