Results 51 to 60 of about 65,595 (212)

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source

Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer [PDF]

, 2019
York University ...
Bhattacharya, Debasmita, Scimè, Anthony
core   +1 more source

Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide [PDF]

Arthritis Research & Therapy, 2009
Abstract Introduction Immunosuppressants, including anti-TNFα antibodies, have remarkable effects in rheumatoid arthritis; however, they increase infectious events. The present study was designed to examine the effects and immunological change of action of altered peptide ligands (APLs) on glucose-6 ...
Iwanami, Keiichi, Matsumoto, Isao, Yoshiga, Yohei, Inoue, Asuka, Kondo, Yuya, Yamamoto, Kayo, Tanaka, Yoko, Minami, Reiko, Hayashi, Taichi, Goto, Daisuke, Ito, Satoshi, Nishimura, Yasuharu, Sumida, Takayuki   +12 more
openaire   +2 more sources

Elevator‐Like Hollow Channels in Porous Scaffolds Accelerate Vascularized Bone Regeneration via NETs‐Fibrin‐Mediated Macrophage Recruitment

Advanced Science, EarlyView.
This study demonstrates that how hollow‐channel scaffolds promote vascularized bone regeneration via an immunomodulatory mechanism. The channel structures facilitate the formation of a neutrophil extracellular traps‐fibrin scaffold that recruits vascular endothelial growth factor A (VEGF‐A)‐secreting M2 macrophages to drive angiogenesis. Combining this
Guifang Wang, Rongpu Liu, Huijing Ma, Shuhan Duan, Guangzheng Yang, LingXi Meng, Yuqin Qiao, Dongqiang Song, Wenjie Zhang   +8 more
wiley   +1 more source

Glucose phosphate isomerase deficiency demasked by whole-genome sequencing: a case report

Journal of Medical Case Reports
Background Glucose-6-phosphate isomerase deficiency is a rare genetic disorder causing hereditary nonspherocytic hemolytic anemia. It is the second most common glycolytic enzymopathy in red blood cells.
Sissel Holme, Richard van Wijk, Andreas Ørslev Rasmussen, Jesper Petersen, Andreas Glenthøj   +4 more
doaj   +1 more source

GPI Is a Prognostic Biomarker and Correlates With Immune Infiltrates in Lung Adenocarcinoma

Frontiers in Oncology, 2021
BackgroundGlucose-6-phosphate isomerase (GPI) plays an important role in glycolysis and gluconeogenesis. However, the role of GPI in lung adenocarcinoma (LUAD) remains unclear.MethodsAll original data were downloaded from The Cancer Genome Atlas (TCGA ...
Jiahui Han, Jiahui Han, Xinzhou Deng, Xinzhou Deng, Renhuang Sun, Ming Luo, Meng Liang, Bing Gu, Te Zhang, Zhen Peng, Ying Lu, Chao Tian, Yutao Yan, Zhiguo Luo, Zhiguo Luo   +14 more
doaj   +1 more source

Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space [PDF]

, 2017
Oxidative protein folding is confined to the bacterial periplasm, endoplasmic reticulum and the mitochondrial intermembrane space. Maintaining a redox balance requires the presence of reductive pathways.
Cardenas-Rodriguez, Mauricio, Tokatlidis, Konstantinos   +1 more
core   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Observing classical nucleation theory at work by monitoring phase transitions with molecular precision. [PDF]

, 2014
It is widely accepted that many phase transitions do not follow nucleation pathways as envisaged by the classical nucleation theory. Many substances can traverse intermediate states before arriving at the stable phase. The apparent ubiquity of multi-step
Durán-Olivencia, MA, Lutsko, J, Maes, D, Sleutel, M, Van Driessche, AE   +4 more
core   +1 more source

Systematic Metabolic Engineering and Model‐Guided Optimization for High‐Level Production of L‐Theanine from Xylose in Escherichia coli

Advanced Science, EarlyView.
This study is pioneering in constructing the shortest known synthetic pathway for L‐theanine production from xylose within E coli. Through comprehensive metabolic engineering strategies, our engineered strain achieved the highest reported L‐theanine titer from xylose, with a titer of 95.42 g/L, and a yield of 0.55 g/g.
Haolin Han, Boyuan Xue, Guangqi Shan, Meng Meng, Shaojie Wang, Haijia Su   +5 more
wiley   +1 more source