Results 101 to 110 of about 2,358,825 (297)

The effect of glucose on cardiac AMP-activated protein kinase [PDF]

, 2009
AMP-activated protein kinase (AMPK) serves as an energy-sensing protein that is activated by a variety of metabolic stresses. Recent studies suggest that AMPK is also regulated by hormones and by nutrients such as glucose and fatty acids.
Tabidi, I.
core  

Individual and combined associations of modifiable metabolic health and lifestyle with low back pain, neck pain, and functional limitation: evidence from a nationally cross-sectional study

BMC Public Health
Background Although healthy lifestyles are prioritized for the self-management of chronic low back pain (LBP) and neck pain (NP), the individual and combined associations of metabolic health and lifestyle with LBP, NP, and related functional limitations ...
Chengxin Xie, Qihang Li, Jingxin Xin, Xiao Jiang, Qiang He, Wenbo Bian, Dongting Yu, Yanru Lin, Zhenyu Yao   +8 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

The sweet life: diet sugar concentration influences paracellular glucose absorption [PDF]

, 2008
Small birds and bats face strong selection pressure to digest food rapidly in order to reduce digesta mass carried during flight. One mechanism is rapid absorption of a high proportion of glucose via the paracellular pathway (transfer between epithelial ...
McWhorter, T., Fleming, P., P. A Fleming, Purchase, Cromwell, Fleming, P.A., Napier, K., Nicolson, S., Nicolson, S.W., C. Purchase, K. R Napier, Purchase, C., Napier, Kathryn R., S. W Nicolson, Nicolson, Sue W., T. J McWhorter, McWhorter, T.J., McWhorter, Todd J., Napier, K.R., Fleming, Patricia A.   +18 more
core   +1 more source

ApoA-I Milano stimulates lipolysis in adipose cells independently of cAMP/PKA activation

Journal of Lipid Research, 2015
ApoA-I, the main protein component of HDL, is suggested to be involved in metabolic homeostasis. We examined the effects of Milano, a naturally occurring ApoA-I variant, about which little mechanistic information is available.
Maria Lindahl, Jitka Petrlova, Jonathan Dalla-Riva, Sebastian Wasserstrom, Catarina Rippe, Joan Domingo-Espin, Dorota Kotowska, Ewa Krupinska, Christine Berggreen, Helena A. Jones, Karl Swärd, Jens O. Lagerstedt, Olga Göransson, Karin G. Stenkula   +13 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Association of the triglyceride glucose-waist height ratio with asymptomatic intracranial arterial stenosis

Lipids in Health and Disease
Background and objective This study evaluated the associations of the triglyceride-glucose (TyG) index or its attendant parameters, known as reliable measures of insulin resistance, with asymptomatic intracranial arterial stenosis (aICAS), along with ...
Yumeng Yang, Liying Guo, Shiqing Song, Xianglong Kong, Yuanyuan Zhao, Xiaotong Ma, Xiang Wang, Hailing Wang, Qinjian Sun   +8 more
doaj   +1 more source

Association of pre-diabetes with the risks of adverse health outcomes and complex multimorbidity: evidence from population-based studies in the NIS and UK Biobank

BMJ Public Health
Introduction This study aimed to examine the risk of common diseases among people with pre-diabetes and explored the relationship between pre-diabetes and multimorbidity (in this case, two or more comorbid diseases).Methods An observational multicohort ...
Yue Zhang, Jiajun Zhao, Zhongshang Yuan, Hang Dong, Mingzhuo Li, Yingzhou Shi, Yafei Wu, Xiude Fan, Zinuo Yuan, Junming Han, Yiping Cheng, Xiaoshan Feng, Zhixiang Wang, Ruirui Xuan, Yingchun Dong, Yang Tian, Qingling Guo, Yongfeng Song   +17 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source