Results 111 to 120 of about 3,131,430 (309)

The Relationship Between Myocardial Fibrosis in Hypertensive Patients With Preserved Ejection Fraction and the Severity of Systemic Inflammatory Status Is Mediated by Epicardial Adipose Tissue: A Multicenter Cohort Study

The Journal of Clinical Hypertension
This study aims to investigate the impact of exacerbated systemic inflammatory status on the degree of myocardial fibrosis and strain impairment in hypertensive patients with preserved ejection fraction, as well as the role played by epicardial adipose ...
Wanting Wang, Runze Zhu, Wenxian Wang, Yan Gao, Jie Liu, Liang Wu, Ximing Wang   +6 more
doaj   +1 more source

Association of lipid accumulation products, or cardiometabolic index with asymptomatic intracranial arterial stenosis: A population-based study in Shandong, China

Journal of Stroke and Cerebrovascular Diseases
Objectives: This study aimed to investigate the association of novel obesity indicators (lipid accumulation product [LAP] and cardiometabolic index [CMI]) with asymptomatic intracranial arterial stenosis (aICAS), particularly in different obesity ...
Xianglong Kong, MS, Qiao Wang, MD, Hailing Wang, MD, Yumeng Yang, MS, Liying Guo, MS, Shiqing Song, MS, Yuanyuan Zhao, MD, Xiaotong Ma, MD, Xiang Wang, MD, Qinjian Sun, MD   +9 more
doaj   +1 more source

Implication of AMPK in glucose-evoked modulation of Na,K-ATPase [PDF]

, 2010
Background and aims: Na,K-ATPase is an integral membrane protein that maintains the gradients of Na+ and K+, using the energy of ATP hydrolysis, maintaining the ionic gradients that allow electrical activity to occur.
Antunes, Célia M., Costa, Ana Rodrigues, Cruz-Morais, Julio   +2 more
core  

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Pixel embedding for grayscale medical image classification

Heliyon
In our paper, we present an extension of text embedding architectures for grayscale medical image classification. We introduce a mechanism that combines n-gram features with an efficient pixel flattening technique to preserve spatial information during ...
Wensu Liu, Na Lv, Jing Wan, Lu Wang, Xiaobei Zhou   +4 more
doaj   +1 more source

One-pot Enzymatic Synthesis of Deoxy-thymidine-diphosphate (TDP)-2-deoxy-∝-d-glucose Using Phosphomannomutase

, 2010
Production of deoxy-thymidine-diphosphate (TDP)-sugars as substrates of glycosyltransferases, has been one of main hurdles for combinatorial antibiotic biosynthesis, which combines sugar moiety with aglycon of various antibiotics. Here, we report the one-
Kang, Young Bok (Abraham), Kim, Byung-Gee, Kim, Dae-Hee, Lee, Hee-Chan, Lee, Kwangwon, Lee, Tek-Hyung, Liou, Kwang-kyung, Park, Sung-Hee, Sohng, Jae-Kyung, Yang, Yung-Hum, Yoo, Dongwon   +10 more
core  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Predictors of Post Prandial Glucose Level in Diabetic Elderly [PDF]

, 2019
Post prandial glucose (PPG) level describes the speed of glucose absorption after 2 hours of macronutrient consumption. By knowing this, we could get the big picture of insulin regulation function and macronutrient metabolism in our body. In elderly, age-
Manungkalit, M. (Maria), Sari, N. P. (Ni)   +1 more
core