Results 71 to 80 of about 2,358,825 (297)

Divergent impacts of estradiol/testosterone reduction on biological aging: optimal HRT window in females recommended

Biology of Sex Differences
Background The age-specific magnitude of the impact of hormones on aging and the role of hormone replacement therapy (HRT) remain unclear. Methods We used data from UK Biobank participants for our analysis.
Yicheng Ma, Junming Han, Qihang Li, Xiao Jiang, Yuan Li, Keke Zhang, Ling Gao   +6 more
doaj   +1 more source

Tirzepatide, a dual GIP/GLP-1 receptor agonist, alleviates metabolic dysfunction-associated steatotic liver disease by reducing the expression of CD36 and OBP2A

Genes and Diseases
Metabolic dysfunction-associated steatotic liver disease (MASLD) is defined by excessive hepatic lipid accumulation. This study evaluated the therapeutic effects and molecular mechanisms of tirzepatide, a dual GIP and GLP-1 receptor agonist, in treating ...
Yun Li, Wencong Sun, Hong Liu, Xiong Z. Ruan   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Strategic locations of white matter hyperintensities associated with cognitive impairment across the cognitive spectrum among rural older adults: a population-based study

Alzheimer’s Research & Therapy
Background The location of white matter hyperintensities (WMH) is crucial for cognitive impairment. We sought to identify tract-based strategic locations of WMH that are associated with cognitive impairment across the cognitive spectrum from low ...
Chunyan Li, Jiafeng Wang, Ziwei Chen, Xiaodong Han, Cuicui Liu, Huisi Zhang, Jie Lu, Yifei Ren, Tao Gong, Yan Wang, Xiaoyu Wang, Qianqian Xie, Tingting Hou, Yongxiang Wang, Lin Cong, Grégoria Kalpouzos, Lin Song, Yifeng Du, Chengxuan Qiu   +18 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Proteomics identifies complement protein signatures in patients with primary biliary cholangitis

European Journal of Medical Research
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease lacking reliable biomarkers for diagnosis or prognosis. To identify plasma complement biomarkers that improve diagnosis and prognosis of PBC.
Xiaolin Ma, Hang Dong, Junming Han, Ming Han, Teng Zhang, Meng Zhou, Xiude Fan, Luna Liu, Zhen Wang   +8 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Impact of glucose and glucoregulation on memory [PDF]

The effect of glucose on memory has been investigated for in excess of 25 years, with some consensus generated amongst the literature indicating that glucose has a facilitating effect.
Elliott, Jade
core  

Pre-exercise galactose and glucose ingestion on fuel utilization during exercise [PDF]

, 2012
Purpose: This study determined the effect of ingesting galactose and glucose 30 minutes prior to exercise on exogenous and endogenous fuel utilization during exercise.
Cooke, C.B., Preston, T., King, R.F.G.J., King, RF, King, Roderick F.G.J., Cooke, CB, O'Hara, J.P., Cooke, Carlton B., Preston, T, Carroll, S, Preston, Thomas, Morrison, D.J., O'Hara, J, Carroll, S., Carroll, Sean, Morrison, Douglas J., Cooke, Carlton, King, Roderick F G J, Morrison, DJ, O'Hara, John P.   +19 more
core   +1 more source

Association between thyroid function and thyroid homeostasis parameters and the prevalence and all-cause and cardiovascular mortality of chronic kidney disease: a population-based study

BMC Public Health
Background To evaluate the relationship between thyroid function and thyroid homeostasis parameters with the prevalence of chronic kidney disease (CKD) and furtherly explore the all-cause and cardiovascular mortality among individuals with CKD using data
Xue Liu, Yuhao Zhang, Yuchen Li, Xiude Fan, Haiqing Zhang   +4 more
doaj   +1 more source