Results 51 to 60 of about 2,358,825 (297)

AI-derived constrained conditional model for screening marker genes through integrated high-throughput transcriptome big data

BMC Medical Research Methodology
Currently, a large volume of high-throughput transcriptome data are accessible through various public databases. This brings urgent need to integrate transcriptome data sourced from numerous independent studies to extract common characteristics to ...
Xiaobei Zhou, Jing Wan, Na Lv, Wensu Liu
doaj   +1 more source

A systemic review on association between on maternal atmospheric pollution exposure during pregnancy and childhood obesity

环境与职业医学
BackgroundMaternal atmospheric pollution during pregnancy may alter fetal intrauterine development programming, thereby increasing the risk of childhood obesity in the future.ObjectiveTo investigate the effects of atmospheric pollution exposure during ...
Lu ZHENG, Borui LIU, Ningyu WAN, Xiaochuan WANG, Zhe YANG, Jiajin HU   +5 more
doaj   +1 more source

Abnormal whole-brain voxelwise structure-function coupling and its association with cognitive dysfunction in patients with different cerebral small vessel disease burdens

Frontiers in Aging Neuroscience, 2023
Cerebral small vessel disease (CSVD) is a universal neurological disorder in older adults that occurs in connection with cognitive dysfunction and is a chief risk factor for dementia and stroke.
Xinyue Zhang, Changhu Liang, Na Wang, Yuanyuan Wang, Yian Gao, Chaofan Sui, Haotian Xin, Mengmeng Feng, Lingfei Guo, Hongwei Wen   +9 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The Role of Branched-Chain Amino Acids and Branched-Chain α-Keto Acid Dehydrogenase Kinase in Metabolic Disorders

Frontiers in Nutrition, 2022
Branched-chain amino acids (BCAAs), composed of leucine, isoleucine, and valine, are important essential amino acids in human physiology. Decades of studies have revealed their roles in protein synthesis, regulating neurotransmitter synthesis, and the ...
Chuang Du, Chuang Du, Chuang Du, Chuang Du, Wen-Jie Liu, Wen-Jie Liu, Wen-Jie Liu, Jing Yang, Jing Yang, Jing Yang, Shan-Shan Zhao, Shan-Shan Zhao, Shan-Shan Zhao, Shan-Shan Zhao, Hui-Xin Liu, Hui-Xin Liu, Hui-Xin Liu   +16 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Glucose modulates event-related potential components of recollection and familiarity in healthy adolescents. [PDF]

, 2009
Introduction Behavioural evidence supports the notion that oral glucose ingestion enhances recognition memory judgements based on recollection, but not familiarity.
Riby, Leigh, Jonathan K. Foster, Riby, L., Smith, M., Foster, Jonathan, Smith, Michael A., Smith, Michael, Leigh M. Riby, van Eekelen, J., Sünram-Lea, Sandra I., van Eekelen, J. A. M., Foster, Jonathan K., Sandra I. Sünram-Lea, Riby, Leigh M., J. A. M. van Eekelen, Michael A. Smith, van Eekelen, Anke, Sünram-Lea, Sandra, Sunram-Lea, S.   +18 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source