Results 41 to 50 of about 2,358,825 (297)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

FSH enhances the inflammatory response of macrophages in the knee joint possibly through the NFκB pathway

FEBS Open Bio
Previous studies have suggested that women with higher follicle‐stimulating hormone (FSH) levels have a greater incidence of osteoarthritis (OA) compared to women with lower FSH despite normal estrogen levels.
Yu Chen, Na Xu, Wen‐wen Zhang, Yan Wang, Tong Su, Yan‐man Zhou, Jin Xu   +6 more
doaj   +1 more source

Research update on the effects of probiotic supplementation during pregnancy on pregnancy complications: a systematic literature review

Zhongguo gonggong weisheng
A growing body of research suggests a correlation between probiotic supplementation during pregnancy and the prevention and treatment of pregnancy complications.
Jing YANG, Xiaochuan WANG, Borui LIU, Xiaoyan ZHANG, Xiaoyu GAO, Jiajin HU   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Therapeutic nutrition strategies for the shared pathophysiology of obesity and sleep-disordered breathings

Nutrition Journal
Sleep-disordered breathings (SDBs) represent both a significant complication and exacerbating factor of obesity, creating a bidirectional relationship that worsens insulin resistance and metabolic dysfunction.
Chunzhuo Xu, Jing Wen, Mengjiao Guo, Jian Zhang, Chen Sun, Xu Liu, Zhaojie Meng, Yang Yu, Deliang Wen   +8 more
doaj   +1 more source

Identification and Spatial Visualization of Dysregulated Bile Acid Metabolism in High-Fat Diet-Fed Mice by Mass Spectral Imaging

Frontiers in Nutrition, 2022
Changes in overall bile acid (BA) levels and specific BA metabolites are involved in metabolic diseases, gastrointestinal, and liver cancer. BAs have become established as important signaling molecules that enable fine-tuned inter-tissue communication ...
Qi Zhang, Qi Zhang, Zhen-Hua Wu, Zhen-Hua Wu, Zhen-Hua Wu, Shan-Shan Zhao, Shan-Shan Zhao, Shan-Shan Zhao, Jing Yang, Jing Yang, Jing Yang, Lei Chen, Lei Chen, Lei Chen, Xiao-Yu Wang, Xiao-Yu Wang, Xiao-Yu Wang, Zhan-You Wang, Hui-Xin Liu, Hui-Xin Liu, Hui-Xin Liu   +20 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Association between fungal dysbiosis in the first 1 000 days of life and childhood diseases – a review of research progress

Zhongguo gonggong weisheng
Bacteria, as the major component of the human microbiome, have been shown to play important physiological roles in human health and disease development.
Xiaoyan ZHANG, Xiaochuan WANG, Borui LIU, Jing YANG, Xiaoyu GAO, Jiajin HU   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Glucoregulatory and order effects on verbal episodic memory in healthy adolescents after oral glucose administration [PDF]

, 2008
The ingestion of oral glucose has been observed to facilitate memory performance in both elderly individuals and in young adults. However, fewer studies have investigated the effect of glucose on memory in children or adolescents.
Jonathan K. Foster, Michael A. Smith, Smith, M., Foster, Jonathan, Smith, Michael   +4 more
core   +1 more source