Results 81 to 90 of about 4,200,175 (352)
Development and application of a self-referencing glucose microsensor for the measurement of glucose consumption by pancreatic ?-cells
, 2001 Glucose gradients generated by an artificial source and ?-cells were measured using an enzyme-based glucose microsensor, 8-?m tip diameter, as a self-referencing electrode.Jung, Sung-Kwon, Sanger, Richard H., Smith, Peter J. S., Trimarchi, James R. +3 morecore +1 more sourceNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Nature Genetics, 2010 Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function ...J. Dupuis, C. Langenberg, I. Prokopenko, R. Saxena, N. Soranzo, A. Jackson, E. Wheeler, N. Glazer, N. Bouatia-Naji, A. Gloyn, C. Lindgren, R. Mägi, A. Morris, J. Randall, T. Johnson, P. Elliott, Denis Rybin, G. Thorleifsson, V. Steinthorsdottir, P. Henneman, H. Grallert, A. Dehghan, J. Hottenga, C. Franklin, P. Navarro, Kijoung Song, A. Goel, J. Perry, J. Egan, T. Lajunen, N. Grarup, T. Sparsø, A. Doney, B. Voight, H. Stringham, Man Li, S. Kanoni, P. Shrader, Christine Cavalcanti-Proença, M. Kumari, L. Qi, N. Timpson, C. Gieger, C. Zabena, G. Rocheleau, E. Ingelsson, P. An, J. O’Connell, J. Luan, A. Elliott, S. Mccarroll, F. Payne, R. Roccasecca, F. Pattou, P. Sethupathy, K. Ardlie, Y. Ariyurek, B. Balkau, P. Barter, J. Beilby, Y. Ben-Shlomo, R. Benediktsson, A. Bennett, S. Bergmann, M. Bochud, E. Boerwinkle, A. Bonnefond, L. Bonnycastle, K. Borch-Johnsen, Y. Böttcher, E. Brunner, S. Bumpstead, G. Charpentier, Y. Chen, P. Chines, R. Clarke, L. Coin, M. Cooper, M. Cornelis, Gabriel J Crawford, L. Crisponi, I. Day, E. D. de Geus, J. Delplanque, C. Dina, M. Erdos, A. Fedson, A. Fischer-Rosinský, N. Forouhi, C. Fox, R. Frants, M. Franzosi, P. Galan, M. Goodarzi, J. Graessler, C. Groves, S. Grundy, R. Gwilliam, U. Gyllensten, S. Hadjadj, G. Hallmans, Naomi Hammond, Xijing Han, A. Hartikainen, N. Hassanali, C. Hayward, S. Heath, S. Hercberg, C. Herder, A. Hicks, D. Hillman, A. Hingorani, A. Hofman, J. Hui, J. Hung, B. Isomaa, P. Johnson, T. Jørgensen, A. Jula, M. Kaakinen, J. Kaprio, Y. Kesaniemi, M. Kivimaki, B. Knight, S. Koskinen, P. Kovacs, K. Kyvik, G. Lathrop, D. Lawlor, O. Le Bacquer, C. Lecoeur, Yun Li, V. Lyssenko, R. Mahley, M. Mangino, A. Manning, M. Martínez-Larrad, J. Mcateer, L. McCulloch, R. McPherson, C. Meisinger, D. Melzer, D. Meyre, B. Mitchell, M. Morken, S. Mukherjee, S. Naitza, Narisu Narisu, M. Neville, B. Oostra, M. Orrù, R. Pakyz, C. Palmer, G. Paolisso, C. Pattaro, Daniel S Pearson, J. Peden, N. Pedersen, M. Perola, A. Pfeiffer, I. Pichler, O. Polašek, D. Posthuma, Simon C. Potter, A. Pouta, M. Province, B. Psaty, W. Rathmann, N. W. Rayner, K. Rice, S. Ripatti, F. Rivadeneira, M. Roden, O. Rolandsson, A. Sandbaek, M. Sandhu, S. Sanna, A. Sayer, P. Scheet, L. Scott, U. Seedorf, S. Sharp, B. Shields, G. Sigurðsson, E. J. G. Sijbrands, A. Silveira, Laila Simpson, A. Singleton, N. Smith, U. Sovio, A. Swift, H. Syddall, A. Syvänen, Toshiko Tanaka, B. Thorand, J. Tichet, A. Tönjes, T. Tuomi, A. Uitterlinden, K. W. van Dijk, M. van Hoek, Dhiraj Varma, S. Visvikis-Siest, V. Vitart, N. Vogelzangs, G. Waeber, Peter J Wagner, A. Walley, G. Walters, K. Ward, H. Watkins, M. Weedon, S. Wild, G. Willemsen, J. Witteman, J. Yarnell, E. Zeggini, D. Zélénika, B. Zethelius, G. Zhai, J. Zhao, M. Zillikens, I. Borecki, R. Loos, P. Meneton, P. Magnusson, D. Nathan, G. Williams, A. Hattersley, K. Silander, V. Salomaa, G. Smith, S. Bornstein, P. Schwarz, J. Spranger, F. Karpe, A. Shuldiner, C. Cooper, G. Dedoussis, M. Serrano-Ríos, A. Morris, L. Lind, L. Palmer, F. Hu, P. Franks, S. Ebrahim, M. Marmot, W. Kao, J. Pankow, M. Sampson, J. Kuusisto, M. Laakso, T. Hansen, O. Pedersen, P. Pramstaller, H. Wichmann, T. Illig, I. Rudan, A. Wright, M. Stumvoll, H. Campbell, James F. Wilson, A. Hamsten, R. Bergman, T. Buchanan, F. Collins, K. Mohlke, J. Tuomilehto, T. Valle, D. Altshuler, J. Rotter, D. Siscovick, B. Penninx, D. Boomsma, P. Deloukas, T. Spector, T. Frayling, L. Ferrucci, A. Kong, U. Thorsteinsdóttir, K. Stefánsson, C. V. van Duijn, Y. Aulchenko, A. Cao, A. Scuteri, D. Schlessinger, M. Uda, A. Ruokonen, M. Jarvelin, D. Waterworth, P. Vollenweider, L. Peltonen, V. Mooser, G. Abecasis, N. Wareham, R. Sladek, P. Froguel, R. Watanabe, J. Meigs, L. Groop, M. Boehnke, M. McCarthy, J. Florez, I. Barroso +303 moresemanticscholar +1 more sourceInhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge +18 morewiley +1 more sourceA high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells. [PDF]
, 2019 Elevated glucose consumption is fundamental to cancer, but selectively targeting this pathway is challenging. We develop a high-throughput assay for measuring glucose consumption and use it to screen non-small-cell lung cancer cell lines against ...Chen, Bao Ying, Clark, Peter M, Damoiseaux, Robert, Ghezzi, Chiara, Ribalet, Bernard, Wong, Alicia +5 morecore +1 more sourceAdaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch +16 morewiley +1 more sourceThe Use of an Anthrone Reagent to Detect Sugar Meals and Their Persistence in the Mosquito \u3ci\u3eAedes Triseriatus\u3c/i\u3e (Diptera: Culicidae) [PDF]
, 2017 Adults of Aedes triseriatus were fed water, blood, and 10% pure and mixed solutions of glucose, fructose and sucrose. Adults were tested for fructose by the cold-anthrone test 0, 1, 4, 12, and 24 h after feeding. Water-fed males and females and blood-fed Kurtz, Richard M, Smith, Stephen Mcore +2 more sourcesCharacterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level
Molecular Oncology, EarlyView.In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz +14 morewiley +1 more source
