Results 81 to 90 of about 3,223,897 (362)

Associations of choroid plexus volume with white matter hyperintensity volume and susceptibility and plasma amyloid markers in cerebral small vessel disease

Alzheimer’s Research & Therapy
Background White matter hyperintensity (WMH) is a key feature of cerebral small vessel disease (CSVD). The impact of the choroid plexus (CP) volume on disease progression remains largely unexplored. This study evaluated the relationship between CP volume
Pengcheng Liang, Meng Li, Yiwen Chen, Zhenyu Cheng, Na Wang, Yuanyuan Wang, Nan Zhang, Yena Che, Jing Li, Changhu Liang, Lingfei Guo   +10 more
doaj   +1 more source

The Use of an Anthrone Reagent to Detect Sugar Meals and Their Persistence in the Mosquito \u3ci\u3eAedes Triseriatus\u3c/i\u3e (Diptera: Culicidae) [PDF]

, 2017
Adults of Aedes triseriatus were fed water, blood, and 10% pure and mixed solutions of glucose, fructose and sucrose. Adults were tested for fructose by the cold-anthrone test 0, 1, 4, 12, and 24 h after feeding. Water-fed males and females and blood-fed
Kurtz, Richard M, Smith, Stephen M
core   +2 more sources

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Glucose Variability [PDF]

Diabetes, 2013
The proposed contribution of glucose variability to the development of the complications of diabetes beyond that of glycemic exposure is supported by reports that oxidative stress, the putative mediator of such complications, is greater for intermittent as opposed to sustained hyperglycemia.
openaire   +2 more sources

Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. [PDF]

, 2012
The altered metabolism of cancer can render cells dependent on the availability of metabolic substrates for viability. Investigating the signaling mechanisms underlying cell death in cells dependent upon glucose for survival, we demonstrate that glucose ...
Graeber, Thomas G, Graham, Nicholas A, Kohli, Bitika, Komisopoulou, Evangelia, Lo, Roger S, Mellinghoff, Ingo K, Mischel, Paul S, Ribas, Antoni, Tahmasian, Martik, Teitell, Michael A, Vivanco, Igor, Wu, Hong, Zhu, Maggie   +12 more
core  

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Metabolomic profiling reveals interindividual metabolic variability and its association with cardiovascular-kidney-metabolic syndrome risk

Cardiovascular Diabetology
Background and objective Cardiovascular-Kidney-Metabolic (CKM) syndrome reflects the interrelated pathophysiology of obesity, insulin resistance, type 2 diabetes, chronic kidney disease, and cardiovascular disease.
Meng Zhou, Wenxiu Sun, Yuhan Gao, Bei Jiang, Tianwei Sun, Rui Xu, Xiujuan Zhang, Qian Wang, Qiuhui Xuan, Shizhan Ma   +9 more
doaj   +1 more source

Fructose transport-deficient Staphylococcus aureus reveals important role of epithelial glucose transporters in limiting sugar-driven bacterial growth in airway surface liquid. [PDF]

, 2014
Hyperglycaemia as a result of diabetes mellitus or acute illness is associated with increased susceptibility to respiratory infection with Staphylococcus aureus.
A Brennan, A Sheludiakova, A Tamer, AA Pezzulo, AL Brennan, Alex J. McCarthy, AR Manolescu, BJ Philips, BJ Philips, BP Cummings, C Siebold, CA Colville, CA Merlo, CI Cheeseman, Daniela Braun, Deborah L. Baines, DM Wood, E Kupeli, EH Baker, EH Baker, Emma H. Baker, FV Donenko, G Saumon, HL Kornberg, I Knezevic, J Plumbridge, James P. Garnett, Jodi A. Lindsay, JP Garnett, JP Garnett, JP Garnett, JP Garnett, K Seidl, K Seidl, KC Strasters, KK Kalsi, KK Kalsi, KL Stanhope, M Faiyaz-Ul-Haque, Matthew R. Farrant, MM Myerburg, MT Le, ND Meadow, PA Dawson, PD Fey, PM Barker, PN Wahjudi, R Pyla, RJ Lee, SJ Curtis, YC Lee   +50 more
core   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Association of pre-diabetes with the risks of adverse health outcomes and complex multimorbidity: evidence from population-based studies in the NIS and UK Biobank

BMJ Public Health
Introduction This study aimed to examine the risk of common diseases among people with pre-diabetes and explored the relationship between pre-diabetes and multimorbidity (in this case, two or more comorbid diseases).Methods An observational multicohort ...
Yue Zhang, Jiajun Zhao, Zhongshang Yuan, Hang Dong, Mingzhuo Li, Yingzhou Shi, Yafei Wu, Xiude Fan, Zinuo Yuan, Junming Han, Yiping Cheng, Xiaoshan Feng, Zhixiang Wang, Ruirui Xuan, Yingchun Dong, Yang Tian, Qingling Guo, Yongfeng Song   +17 more
doaj   +1 more source