Results 61 to 70 of about 22,279 (302)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Novel Model of Neuronal Bioenergetics: Postsynaptic Utilization of Glucose but not Lactate Correlates Positively with Ca Signalling in Cultured Mouse Glutamatergic Neurons

ASN Neuro, 2012
We have previously investigated the relative roles of extracellular glucose and lactate as fuels for glutamatergic neurons during synaptic activity. The conclusion from these studies was that cultured glutamatergic neurons utilize glucose rather than ...
Lasse K. Bak, Linea F. Obel, Anne B. Walls, Arne Schousboe, Sevan A.A. Faek, Farah S. Jajo, Helle S. Waagepetersen   +6 more
doaj   +1 more source

The influence of transketolase on lipid biosynthesis in the yeast Yarrowia lipolytica

Microbial Cell Factories, 2020
Background During the pentose phosphate pathway (PPP), two important components, NADPH and pentoses, are provided to the cell. Previously it was shown that this metabolic pathway is a source of reducing agent for lipid synthesis from glucose in the yeast
Adam Dobrowolski, Aleksandra M. Mirończuk   +1 more
doaj   +1 more source

EFFECT OF TWO PLANT EXTRACTS ON SOME BIOCHEMICAL PARAMETERS IN THE FRUIT FLY Ceratitis capitata Larvae (Weid) [PDF]

Journal of Plant Protection and Pathology, 2005
Half lethal doses (LCsol of crude ethanohc extracts of Vinca rosea and Melia azedaracfl leaves (80 and SOppm. respectively) induced significant biochemical alterations in the second instar Larvae ( L2) of the fruit fly Ceratitis cap < /em>itata ...
Afaf Abbas,
doaj   +1 more source

Cofactor Specificity of Glucose-6-Phosphate Dehydrogenase Isozymes in Pseudomonas putida Reveals a General Principle Underlying Glycolytic Strategies in Bacteria

mSystems, 2021
Glucose-6-phosphate dehydrogenase (G6PDH) is widely distributed in nature and catalyzes the first committing step in the oxidative branch of the pentose phosphate (PP) pathway, feeding either the reductive PP or the Entner-Doudoroff pathway.
Daniel Christoph Volke, Karel Olavarría, Pablo Iván Nikel   +2 more
doaj   +1 more source

Glucose-6-phosphate dehydrogenase deficiency [PDF]

Postgraduate Medical Journal, 1994
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most commonly known inherited disorder in man, and is estimated to affect 400 million people worldwide.' The highest prevalence rates (with gene frequencies in the range of 5-25% are found in tropical Africa, the Middle East, tropical and sub-tropical Asia, some parts of the Mediterranean, and ...
openaire   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Structural basis of L-glucose oxidation by scyllo-inositol dehydrogenase: Implications for a novel enzyme subfamily classification. [PDF]

PLoS ONE, 2018
For about 70 years, L-glucose had been considered non-metabolizable by either mammalian or bacterial cells. Recently, however, an L-glucose catabolic pathway has been discovered in Paracoccus laeviglucosivorans, and the genes responsible cloned.
Kazuhiro Fukano, Kunio Ozawa, Masaya Kokubu, Tetsu Shimizu, Shinsaku Ito, Yasuyuki Sasaki, Akira Nakamura, Shunsuke Yajima   +7 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source