Results 91 to 100 of about 680,483 (305)

(Pro)renin receptor signaling in hypothalamic tyrosine hydroxylase neurons is required for obesity-associated glucose metabolic impairment

JCI Insight
Glucose homeostasis is achieved via complex interactions between the endocrine pancreas and other peripheral tissues and glucoregulatory neurocircuits in the brain that remain incompletely defined.
Shiyue Pan, Lucas A.C. Souza, Caleb J. Worker, Miriam E. Reyes Mendez, Ariana Julia B. Gayban, Silvana G. Cooper, Alfredo Sanchez Solano, Richard N. Bergman, Darko Stefanovski, Gregory J. Morton, Michael W. Schwartz, Yumei Feng Earley   +11 more
doaj   +1 more source

Tamoxifen suppresses pancreatic β-cell proliferation in mice.

PLoS ONE, 2019
Tamoxifen is a mixed agonist/antagonist estrogen analogue that is frequently used to induce conditional gene deletion in mice using Cre-loxP mediated gene recombination.
Surl-Hee Ahn, Anne Granger, Matthew M Rankin, Carol J Lam, Aaron R Cox, Jake A Kushner   +5 more
doaj   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

Gut microbiota-derived extracellular vesicles exhibit diurnal regulation and activate hepatic gluconeogenesis

Molecular Metabolism
The circadian clock regulates tissue-specific homeostasis, and its disruption is associated with metabolic disorders. Both host metabolic processes and the gut microbiota exhibit diurnal regulation, and both contribute to the maintenance of glucose ...
Jian Tan, Jemma Justine Taitz, Duan Ni, Camille Potier-Villette, Gabriela Pinget, Tamara Pulpitel, Dragana Stanley, Ralph Nanan, Laurence Macia   +8 more
doaj   +1 more source

A parsimonious model of blood glucose homeostasis

PLOS Digital Health, 2022
The mathematical modelling of biological systems has historically followed one of two approaches: comprehensive and minimal. In comprehensive models, the involved biological pathways are modelled independently, then brought together as an ensemble of ...
Eric Ng, Jaycee M. Kaufman, Lennaert van Veen, Yan Fossat   +3 more
doaj  

Linoleic acid and the regulation of glucose homeostasis: A review of the evidence

, 2021
Jakob Hamilton, Eric L. Klett
openalex   +2 more sources

Astrocyte‐Guided Maturation of Neural Constructs in a Modular Biosynthetic Hydrogel for Biohybrid Neurotechnologies

Advanced Functional Materials, EarlyView.
A modular biosynthetic PVA–gelatin hydrogel crosslinked via visible‐light thiol‐ene chemistry is engineered as a coating for neural electrodes. Optimizing matrix composition and mechanical properties enables the hydrogel to support astrocytic populations that guide neural differentiation and functional maturation.
Martina Genta, Sofia Peressotti, Roberto Portillo‐Lara, Josef Goding, Rylie Green   +4 more
wiley   +1 more source

Anchored phosphatases modulate glucose homeostasis.

The EMBO journal, 2012
Endocrine release of insulin principally controls glucose homeostasis. Nutrient-induced exocytosis of insulin granules from pancreatic β-cells involves ion channels and mobilization of Ca(2+) and cyclic AMP (cAMP) signalling pathways. Whole-animal physiology, islet studies and live-β-cell imaging approaches reveal that ablation of the kinase ...
Hinke, Simon A, Navedo, Manuel F, Ulman, Allison, Whiting, Jennifer L, Nygren, Patrick J, Tian, Geng, Jimenez‐Caliani, Antonio J, Langeberg, Lorene K, Cirulli, Vincenzo, Tengholm, Anders, Dell'Acqua, Mark L, Santana, L Fernando, Scott, John D   +12 more
openaire   +4 more sources

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source