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Ghrelin and glucose homeostasis
Peptides, 2011Ghrelin plays an important physiological role in modulating GH secretion, insulin secretion and glucose metabolism. Ghrelin has direct effects on pancreatic islet function. Also, ghrelin is part of a mechanism that integrates the physiological response to fasting.
Delhanty, Patric +1 more
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Kisspeptin and Glucose Homeostasis
Seminars in Reproductive Medicine, 2019AbstractKisspeptin has well-established critical roles in the control of reproduction and fertility. Recently, evidence has emerged that suggests kisspeptin may have additional roles in the regulation of glucose homeostasis. Conflicting reports on the effects of kisspeptin on insulin secretion in animal models have been published, which cannot be fully
Izzi-Engbeaya, Chioma +2 more
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Evaluation of Glucose Homeostasis
Current Protocols in Molecular Biology, 2007AbstractObesity and dyslipidemia are often found in association with insulin resistance (IR). These components combined with hypertension characterize the most common endocrine disorder in humans, the metabolic syndrome. Thus, in addition to profiling body weight evolution and lipid metabolites, glucose tolerance (a reflection of IR) and insulin ...
Sami, Heikkinen +3 more
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Central Regulation of Glucose Homeostasis
Comprehensive Physiology, 2017ABSTRACTThe ability of the brain to directly control glucose levels in the blood independently of its effects on food intake and body weight has been known ever since 1854 when Claude Bernard, a French physiologist, discovered that lesioning the floor of the fourth ventricle in rabbits led to a rise of sugar in the blood.
Tups A. +4 more
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Growth Hormone and Glucose Homeostasis
Hormone Research in Paediatrics, 2004Patients with active acromegaly are insulin-resistant and glucose-intolerant, whereas children with growth hormone (GH) deficiency (GHD) are insulin-sensitive and may develop fasting hypoglycaemia. Surprisingly, however, hypopituitary adults with unsubstituted GHD tend to be insulin-resistant, which may worsen during GH substitution.
Jørgensen, J.O.L. +6 more
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The American Journal of Digestive Diseases, 1955
The diagnosis of functional hyperinsulinism would be made more frequently if the test for that condition were made more reliable and less confusing. It is proposed that the test be called “the glucose homeostasis test” rather than the currently used expression, “six hour glucose tolerance test” because the former term is actually what is determined ...
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The diagnosis of functional hyperinsulinism would be made more frequently if the test for that condition were made more reliable and less confusing. It is proposed that the test be called “the glucose homeostasis test” rather than the currently used expression, “six hour glucose tolerance test” because the former term is actually what is determined ...
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Brain glucose sensing mechanism and glucose homeostasis
Current Opinion in Clinical Nutrition and Metabolic Care, 2002Glucose homeostasis must be finely regulated. Changes in glucose levels elicit a complex neuroendocrine response that prevents or rapidly corrects hyper- or hypoglycemia. It is well established that different parts of the brain, particularly the hypothalamus and the brain stem, are important centres involved in the monitoring of glucose status and the ...
Pénicaud, Luc +4 more
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Neuroscience of glucose homeostasis
2014Plasma glucose concentrations are homeostatically regulated and maintained within strict boundaries. Several mechanisms are in place to increase glucose output when glucose levels in the circulation drop as a result of glucose utilization, or to decrease glucose output and increase tissue glucose uptake to prevent hyperglycemia.
La Fleur, S. E. +2 more
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Mechanisms of blood glucose homeostasis
Journal of Inherited Metabolic Disease, 1990SummaryThe mechanisms by which glycogen metabolism, glycolysis and gluconeogenesis are controlled in the liver both by hormones and by the concentration of glucose are reviewed. The control of glycogen metabolism occurs by phosphorylation and dephosphorylation of both glycogen phosphorylase and glycogen synthase catalysed by various protein kinases and
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