Results 281 to 290 of about 590,245 (355)

Time and dose selective glucose metabolism for glucose homeostasis and energy conversion in the liver. [PDF]

NPJ Syst Biol Appl
Pan Y, Hatano A, Ohno S, Morita K, Kokaji T, Bai Y, Sugimoto H, Egami R, Terakawa A, Li D, Uematsu S, Maehara H, Fujita S, Inoue H, Inaba Y, Nagano AJ, Hirayama A, Soga T, Kuroda S.   +18 more
europepmc   +1 more source

Oral Engineered Extracellular Vesicles Based on Ion Exchange Strategy for Multipronged Management of Wilson's Disease Complicated with Reproductive Dysfunction Therapy

Advanced Science, EarlyView.
This study reports for the first time an oral targeted nanomedicine that conducts ion exchange through engineered Ganoderma‐derived extracellular vesicle, managing both the in‐copper and ex‐copper in a multi‐pronged approach, offering a promising therapeutic strategy for addressing WD with reproductive dysfunction.
Tingting Wang, Wengui Lu, Zhifei Cheng, Luyao Wang, Zhenzhen Jiang, Yike Yue, Pengyu Jiang, Zehua Xia, Lei He, Fengying Wang, Limin Wu, Qi Wang, Hui Han   +12 more
wiley   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

Regulation of Energy and Glucose Homeostasis by the Nucleus of the Solitary Tract and the Area Postrema. [PDF]

Endocrinol Metab (Seoul)
Bruce K, Garrido AN, Zhang SY, Lam TKT.
europepmc   +1 more source

The TET3/GATA6 Axis Drives Lipid Metabolism and Therapeutic Vulnerabilities in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu, Shaobo Kang, Na Lin, Wenqi Zhang, Shiwen Wang, Yuqing Ren, Xiaofan Ding, Jianxiu Yu, Ruiyu Xie   +8 more
wiley   +1 more source

Insulin at the intersection of thermoregulation and glucose homeostasis. [PDF]

Mol Metab
Winn NC, Schleh MW, Garcia JN, Lantier L, McGuinness OP, Blair JA, Hasty AH, Wasserman DH.   +7 more
europepmc   +1 more source

Emerging Nanotechnology Strategies for Obesity Therapy

Advanced Science, EarlyView.
Three types of nanomaterials used for obesity treatment are highlighted, including inorganic nanomaterials, organic nanomaterials and biomimetic nanomaterials. A detailed and comprehensive introduction to the recent nanotechnology strategies for obesity management is also provided, including drug delivery, photodynamic therapy, hyperthermia, gas ...
Weili Chang, Zhaoxu Meng, Yuezhu Zhao, Yake Qi, Zhou Li, He Lian   +5 more
wiley   +1 more source

Insulin Signaling Pathway Mediates FoxO-Pepck Axis Regulation of Glucose Homeostasis in Drosophila suzukii. [PDF]

Int J Mol Sci
Zang S, Wang R, Liu Y, Zhao S, Su L, Dai X, Chen H, Yin Z, Zheng L, Liu Q, Zhai Y.   +10 more
europepmc   +1 more source

Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy

Advanced Science, EarlyView.
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao, Xianping Liu, Xu Chu, Feixiang Chen, Ruicheng Shi, Zonghao Liu, Yelin Wu, Yanyan Liu, Wenbo Bu   +8 more
wiley   +1 more source

Comparative Effects of GLP-1 and GLP-2 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation. [PDF]

Biomolecules
Ali A, Khan D, Dubey V, Tarasov AI, Flatt PR, Irwin N.   +5 more
europepmc   +1 more source