Results 291 to 300 of about 590,245 (355)

The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress

Advanced Science, EarlyView.
This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu, Yi Shi, Chao‐Hua Kong, Ai‐Qun Chen, Ying Kang, Jun‐Yan Kan, Xiao‐Min Jiang, Peng Chu, Dong‐Chen Wang, Yi‐Fei Lv, Zhi‐Yuan Qian, Zi‐Hao Jiang, Yun‐Wei Chen, Yue Sun, Rui‐Rui Chang, Wen‐Ying Zhou, Yue Gu, Jun‐Xia Zhang, Shao‐Liang Chen   +18 more
wiley   +1 more source

Prex1 controls glucose homeostasis by limiting glucose uptake and mitochondrial metabolism in liver through GEF-independent regulation of Gpr21

Chu JY, Tsonou E, Machin PA, MacLellan-Gibson K, Roberts A, Chetwynd SA, McCormack AT, Stephens JC, Benetti E, Kinsella GK, Baker D, Hornigold DC, Welch HCE.   +12 more
europepmc   +1 more source

The mediatory role of androgens on sex differences in glucose homeostasis and incidence of type 2 diabetes: the KORA study. [PDF]

Cardiovasc Diabetol
Raeisi-Dehkordi H, Thorand B, Beigrezaei S, Peters A, Rathman W, Adamski J, Chatelan A, van der Schouw YT, Franco OH, Muka T, Nano J.   +10 more
europepmc   +1 more source

A Complementarity‐Based Approach to De Novo Binder Design

Advanced Science, EarlyView.
A novel method for surface complementarity detection (HECTOR) enables highly efficient docking and design of protein interfaces. Applied to therapeutically relevant targets, this method yields de novo binders with potent antagonistic activity. As a first‐principles approach, HECTOR offers a training‐free solution to the binder design problem and is ...
Kateryna Maksymenko, Valeriia Hatskovska, Murray Coles, Narges Aghaallaei, Natalia Pashkovskaia, Natalia Borbarán‐Bravo, Matteo Pilz, Philip Bucher, Mareike Volz, Joana Pereira, Marcus D. Hartmann, Ghazaleh Tabatabai, Judith Feucht, Stefan Liebau, Patrick Müller, Andrei N. Lupas, Julia Skokowa, Mohammad ElGamacy   +17 more
wiley   +1 more source

Volatile organic compounds exposure in relation to glucose homeostasis and type 2 diabetes in older adults from the NHANES. [PDF]

Sci Rep
Li C, Wang J, Wang L, Guo J, Li J, Li X, Li L, Zhang J, Suo X.   +8 more
europepmc   +1 more source

4-Hexylresorcinol Enhances Glut4 Expression and Glucose Homeostasis via AMPK Activation and Histone H3 Acetylation. [PDF]

Int J Mol Sci
Che X, Oh JH, Kang YJ, Kim DW, Kim SG, Choi JY, Garagiola U.   +6 more
europepmc   +1 more source

Fish-hunting cone snail disrupts prey's glucose homeostasis with weaponized mimetics of somatostatin and insulin. [PDF]

Nat Commun
Yeung HY, Ramiro IBL, Andersen DB, Koch TL, Hamilton A, Bjørn-Yoshimoto WE, Espino S, Vakhrushev SY, Pedersen KB, de Haan N, Hipgrave Ederveen AL, Olivera BM, Knudsen JG, Bräuner-Osborne H, Schjoldager KT, Holst JJ, Safavi-Hemami H.   +16 more
europepmc   +1 more source

Probiotic Supplementation Improves Glucose Homeostasis and Modulates Interleukin (IL)-21 and IL-22 Levels in Pediatric Patients with Type 1 Diabetes: A Randomized Placebo-Controlled Trial. [PDF]

Metabolites
Adly AAM, Ismail EAR, Abd-Elgawad MM, Salah NY.   +3 more
europepmc   +1 more source

Maternal glucose homeostasis during pregnancy in women with overweight or obesity and offspring metabolic health. [PDF]

Sci Rep
Mogensen CS, Nygaard M, Kampmann U, Mølgaard C, Magkos F, Geiker NRW.   +5 more
europepmc   +1 more source