Results 41 to 50 of about 778,750 (285)

Effect of Orexin-A on Post-ischemic Glucose Intolerance and Neuronal Damage

Journal of Pharmacological Sciences, 2011
Orexin-A is a newly identified neuropeptide expressed in the lateral areas of the hypothalamus that plays a role in various physiological functions, including regulation of glucose metabolism.
Shinichi Harada, Wakako Fujita-Hamabe, Shogo Tokuyama   +2 more
doaj   +1 more source

Tolerance to coxibs in patients with intolerance to non-steroidal anti-inflammatory drugs (NSAIDs) : a systematic structured review of the literature [PDF]

, 2007
Adverse events triggered by non-steroidal anti-inflammatory drugs (NSAIDs) are among the most common drug-related intolerance reactions in medicine; they are possibly related to inhibition of cyclooxygenase-1.
Weberschock, Tobias Bernd Bernd, Boehncke, Wolf-Henning, Tobias Bernd Weberschock, Sylke-Monina Müller, Sandra Boehncke, Müller, Sylke-Monina, Wolf-Henning Boehncke, Weberschock, Tobias Bernd, Boehncke, Sandra   +8 more
core   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

High fat diet-induced glucose intolerance impairs myocardial function, but not myocardial perfusion during hyperaemia: a pilot study

Cardiovascular Diabetology, 2012
Background Glucose intolerance is a major health problem and is associated with increased risk of progression to type 2 diabetes mellitus and cardiovascular disease.
van den Brom Charissa E, Bulte Carolien S E, Kloeze B, Loer Stephan A, Boer Christa, Bouwman R   +5 more
doaj   +1 more source

Glucose intolerance and dementia

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2011
耐糖能障害―肥満・メタボリックシンドローム・糖尿病―は，認知障害や認知症のリスクファクターである．医師を対象とした認知症診療に関するアンケート調査では，生活習慣病を有する高齢者では，認知症が見逃されやすいことが示された．認知症の早期発見には，医師のみならずケアスタッフの教育や認知症を積極的に疑うことが重要と考えられる．高齢者糖尿病の脳を守るために，代謝性脳症予防の視点からは，随時血糖を270 mg/dl 以下に管理することは合理的な目標値と考えられる．アルツハイマー型認知症の動物実験モデルでも，神経細胞障害を抑制するために，高血糖・低血糖，急峻な血糖変動を避けることが重要であった．今後，アミロイド神経病変の抑制，ADLの維持という視点から，更なる具体的な血糖管理目標値が提唱されるべきである．
openaire   +3 more sources

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Insulin resistance in pulmonary arterial hypertension, is it a novel disease modifier?

Research in Cardiovascular Medicine, 2014
Background: Recent studies have introduced glucose intolerance and insulin resistance (IR) as novel risk factors in patients with pulmonary arterial hypertension (PAH).
Nasim Naderi, Pedram Boobejame, Hooman Bakhshandeh, Ahmad Amin, Sepideh Taghavi, Majid Maleki   +5 more
doaj   +1 more source

L‐Cysteine and N‐Acetylcysteine Supplementation Improves Clinical Outcome in a Patient With COXPD10

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT MTO1 is a nuclear gene that encodes a mitochondrial protein essential for modifying mitochondrial transfer RNAs (tRNAs) and stabilizing codon‐anticodon interactions to ensure accurate and efficient mitochondrial protein synthesis and oxidative phosphorylation.
Nishitha R. Pillai, Sara A. Elsbecker, Grace Bronken McCarthy, Kaitlin Weisshappel, Peter Karachunski, Fernando Scaglia   +5 more
wiley   +1 more source

Postpartum Glucose Intolerance in Gestational Diabetes Mellitus Women

Thai Journal of Obstetrics and Gynaecology, 2009
Objective: To study the prevalence of and determine antepartum factors for postpartum glucose intolerance in women with gestational diabetes mellitus (GDM). Materials and Methods: Medical records of women who had been diagnosed with GDM and underwent
Pirun Pitahongnan, Chadakarn Phaloprakarn, Sumonmal Manusirivithaya, Budsaba Wiriyasirivaj   +3 more
doaj