Results 91 to 100 of about 853,847 (318)

Association of the triglyceride glucose-waist height ratio with asymptomatic intracranial arterial stenosis

Lipids in Health and Disease
Background and objective This study evaluated the associations of the triglyceride-glucose (TyG) index or its attendant parameters, known as reliable measures of insulin resistance, with asymptomatic intracranial arterial stenosis (aICAS), along with ...
Yumeng Yang, Liying Guo, Shiqing Song, Xianglong Kong, Yuanyuan Zhao, Xiaotong Ma, Xiang Wang, Hailing Wang, Qinjian Sun   +8 more
doaj   +1 more source

Association of pre-diabetes with the risks of adverse health outcomes and complex multimorbidity: evidence from population-based studies in the NIS and UK Biobank

BMJ Public Health
Introduction This study aimed to examine the risk of common diseases among people with pre-diabetes and explored the relationship between pre-diabetes and multimorbidity (in this case, two or more comorbid diseases).Methods An observational multicohort ...
Yue Zhang, Jiajun Zhao, Zhongshang Yuan, Hang Dong, Mingzhuo Li, Yingzhou Shi, Yafei Wu, Xiude Fan, Zinuo Yuan, Junming Han, Yiping Cheng, Xiaoshan Feng, Zhixiang Wang, Ruirui Xuan, Yingchun Dong, Yang Tian, Qingling Guo, Yongfeng Song   +17 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

The effect of glucose on cardiac AMP-activated protein kinase

, 2009
AMP-activated protein kinase (AMPK) serves as an energy-sensing protein that is activated by a variety of metabolic stresses. Recent studies suggest that AMPK is also regulated by hormones and by nutrients such as glucose and fatty acids.
Tabidi, I.
core  

Skeletal muscle mTORC1 regulates whole-body metabolism [PDF]

, 2015
Skeletal muscle, which represents over 40% of the total body mass, is a dynamic tissue with a key role in the maintenance of metabolic homeostasis. Several lines of evidence indicate that alterations of the normal muscle function, as for example in ...
Ormazabal, Maitea Guridi
core   +1 more source

Cognitive impairment and amygdala subregion volumes in elderly with cerebral small vessel disease: A large prospective cohort study

Neurobiology of Disease
Although the amygdala is associated with cognitive impairment resulting from cerebral small vessel disease, the relationship between alterations in amygdala structure and cerebral small vessel disease (CSVD) remains controversial. Given that the amygdala
Zhenyu Cheng, Linfeng Yang, Jing Li, Yiwen Chen, Pengcheng Liang, Yuanyuan Wang, Na Wang, Xinyue Zhang, Yian Gao, Chaofan Sui, Meng Li, Changhu Liang, Lingfei Guo   +12 more
doaj   +1 more source

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi, Mohanad A. Alkuwaiti, Yazeed B. Alaql, Ahmed K. Alsaif, Ahmed A. Alessa, Meshari Ayed Alharbi, Mohammed Alfalah, Saud A. Alnaaim, Sajjad M. AlHaddad, Ahmed Y. Azzam   +9 more
wiley   +1 more source

The Relationship Between Myocardial Fibrosis in Hypertensive Patients With Preserved Ejection Fraction and the Severity of Systemic Inflammatory Status Is Mediated by Epicardial Adipose Tissue: A Multicenter Cohort Study

The Journal of Clinical Hypertension
This study aims to investigate the impact of exacerbated systemic inflammatory status on the degree of myocardial fibrosis and strain impairment in hypertensive patients with preserved ejection fraction, as well as the role played by epicardial adipose ...
Wanting Wang, Runze Zhu, Wenxian Wang, Yan Gao, Jie Liu, Liang Wu, Ximing Wang   +6 more
doaj   +1 more source

Studies on Glucose Metabolism [PDF]

BMJ, 1964
A R, WALKER, B D, RICHARDSON, S D, MISTRY   +2 more
openaire   +2 more sources

A 17 Year Old With Developmental Delay Presenting With Increasing Confusion and Imbalance

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Methylmalonic acidemia is an autosomal recessive genetic disorder primarily caused by defects in methylmalonyl‐CoA mutase and cobalamin (vitamin B12) metabolism. These defects disrupt the tricarboxylic acid cycle and oxidative phosphorylation, leading to the abnormal accumulation of metabolic products such as methylmalonic acid, propionic acid,
Wei Zhao, Yingli Zhang, Hongliang Zheng
wiley   +1 more source