Results 91 to 100 of about 2,165,842 (306)

Association between advanced glycation end products and impaired fasting glucose : results from the SALIA study [PDF]

, 2015
Advanced glycation end products (AGEs) may contribute to the development of type 2 diabetes and related complications, whereas their role in the early deterioration of glycaemia is unknown.
Annette Peßler, Thomas Henle, Vierkötter, Andrea, Roden, Michael, Juliane Freund, Ursula Krämer, Schulte, Thomas, Michael Hellwig, Tamara Schikowski, Mohammad Vossoughi, Christian Luckhaus, Christian Herder, Tom Teichert, Luckhaus, Christian, Vossoughi, Mohammad, Thomas Schulte, Barbara Hoffmann, Schikowski, Tamara, Krämer, Ursula, Sugiri, Dorothea, Dorothea Sugiri, Hoffmann, Barbara, Hellwig, Michael, Anne Hellwig, Andrea Vierkötter, Henle, Thomas, Michael Roden, Freund, Juliane, Teichert, Tom, Hellwig, Anne, Peßler, Annette, Herder, Christian   +31 more
core   +2 more sources

Association of the triglyceride glucose-waist height ratio with asymptomatic intracranial arterial stenosis

Lipids in Health and Disease
Background and objective This study evaluated the associations of the triglyceride-glucose (TyG) index or its attendant parameters, known as reliable measures of insulin resistance, with asymptomatic intracranial arterial stenosis (aICAS), along with ...
Yumeng Yang, Liying Guo, Shiqing Song, Xianglong Kong, Yuanyuan Zhao, Xiaotong Ma, Xiang Wang, Hailing Wang, Qinjian Sun   +8 more
doaj   +1 more source

Association of pre-diabetes with the risks of adverse health outcomes and complex multimorbidity: evidence from population-based studies in the NIS and UK Biobank

BMJ Public Health
Introduction This study aimed to examine the risk of common diseases among people with pre-diabetes and explored the relationship between pre-diabetes and multimorbidity (in this case, two or more comorbid diseases).Methods An observational multicohort ...
Yue Zhang, Jiajun Zhao, Zhongshang Yuan, Hang Dong, Mingzhuo Li, Yingzhou Shi, Yafei Wu, Xiude Fan, Zinuo Yuan, Junming Han, Yiping Cheng, Xiaoshan Feng, Zhixiang Wang, Ruirui Xuan, Yingchun Dong, Yang Tian, Qingling Guo, Yongfeng Song   +17 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Compartmentation of glycogen metabolism revealed from 13C isotopologue distributions [PDF]

, 2011
Background: Stable isotope tracers are used to assess metabolic flux profiles in living cells. The existing methods of measurement average out the isotopic isomer distribution in metabolites throughout the cell, whereas the knowledge of compartmental ...
Marin, Silvia, Loranne Agius, Selivanov, Vitaly, Marta Cascante, Roca Elias, Josep, Oresic, Matej, Cascante i Serratosa, Marta, Cascante, Marta, Igor Marin de Mas, Josep Roca, Marín Martínez, Silvia, Selivanov, Vitaly A., de Mas, Igor Marin, Silvia Marin, Agius, Loranne, Vitaly A Selivanov, Matej Orešič, Marín de Mas, Igor Bartolomé, Roca, Josep   +18 more
core   +1 more source

The Relationship Between Myocardial Fibrosis in Hypertensive Patients With Preserved Ejection Fraction and the Severity of Systemic Inflammatory Status Is Mediated by Epicardial Adipose Tissue: A Multicenter Cohort Study

The Journal of Clinical Hypertension
This study aims to investigate the impact of exacerbated systemic inflammatory status on the degree of myocardial fibrosis and strain impairment in hypertensive patients with preserved ejection fraction, as well as the role played by epicardial adipose ...
Wanting Wang, Runze Zhu, Wenxian Wang, Yan Gao, Jie Liu, Liang Wu, Ximing Wang   +6 more
doaj   +1 more source

Cognitive impairment and amygdala subregion volumes in elderly with cerebral small vessel disease: A large prospective cohort study

Neurobiology of Disease
Although the amygdala is associated with cognitive impairment resulting from cerebral small vessel disease, the relationship between alterations in amygdala structure and cerebral small vessel disease (CSVD) remains controversial. Given that the amygdala
Zhenyu Cheng, Linfeng Yang, Jing Li, Yiwen Chen, Pengcheng Liang, Yuanyuan Wang, Na Wang, Xinyue Zhang, Yian Gao, Chaofan Sui, Meng Li, Changhu Liang, Lingfei Guo   +12 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Multiple Demographic, Lifestyle, and Biological Factors Associated With Brain Iron Deposition in the Basal Ganglia: A Comprehensive Analysis of 25,980 UK Biobank Participants

Brain and Behavior
Background The susceptibility values of the basal ganglia reflect the health status of these nuclei. We aimed to explore the associations between various demographic characteristics, lifestyle factors, and biological factors that have the potential to ...
Pengcheng Liang, Linfeng Yang, Yiwen Chen, Zhenyu Cheng, Yian Gao, Chaofan Sui, Xinyue Zhang, Na Wang, Yuanyuan Wang, Changhu Liang, Lingfei Guo   +10 more
doaj   +1 more source