Results 71 to 80 of about 2,165,842 (306)

Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease. [PDF]

, 2014
Unlike most other cell types, neurons preferentially metabolize glucose via the pentose phosphate pathway (PPP) to maintain their antioxidant status. Inhibiting the PPP in neuronal cell models causes cell death.
Allen, GF, Holton, Janice L., Dunn, L, Pope, Simon, Li, A, Lees, A, Li, Abi, Ling, Helen, Lees, Andrew, Allen, George FG., Heales, SJ, Duberley, KE, Hargreaves, Iain P., Dunn, Laura, Allen, George F. G., Mamais, A, Mamais, Adamantios, Bandopadhyay, Rina, Hargreaves, IP, Holton, JL, Bandopadhyay, R, Ling, H, Duberley, Kate E., Pope, S, Heales, Simon J.   +24 more
core   +1 more source

Differential impact of N-Methyl-D-Aspartate Receptor antagonists on genes involved in synaptic plasticity and neural glucose metabolism: implication for psychosis. [PDF]

, 2011
Background: NMDA-R-hypofunction (NRH) is considered one of the putative molecular mechanism involved in psychosis. Several studies show that an imbalance of dopamine–glutamate transmission has a key role in psychosis pathophysiology.
Sarappa, Chiara
core   +1 more source

Metabolomic profiling reveals interindividual metabolic variability and its association with cardiovascular-kidney-metabolic syndrome risk

Cardiovascular Diabetology
Background and objective Cardiovascular-Kidney-Metabolic (CKM) syndrome reflects the interrelated pathophysiology of obesity, insulin resistance, type 2 diabetes, chronic kidney disease, and cardiovascular disease.
Meng Zhou, Wenxiu Sun, Yuhan Gao, Bei Jiang, Tianwei Sun, Rui Xu, Xiujuan Zhang, Qian Wang, Qiuhui Xuan, Shizhan Ma   +9 more
doaj   +1 more source

Association of Sleep Duration With Incident Carotid Plaque: A Prospective Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Sleep is an important determinant of cardiovascular health. We sought to investigate the longitudinal association between sleep duration and incident carotid plaque in a rural Chinese population.
Meijie Chen, Xiaotong Ma, Yuan Xue, Xiang Wang, Yuanyuan Zhao, Peng Yan, Xiaohui Liu, Yifeng Du, Chengxuan Qiu, Qinjian Sun   +9 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Alteration of de novo glucose production contributes to fasting hypoglycaemia in fyn deficient mice [PDF]

, 2013
Previous studies have demonstrated that glucose disposal is increased in the Fyn knockout (FynKO) mice due to increased insulin sensitivity. FynKO mice also display fasting hypoglycaemia despite decreased insulin levels, which suggested that hepatic ...
Bastie, Claire C., Kurland, Irwin J., Elena Tarabra, Gustavo Palacios, Jeffrey E Pessin, Yang Yingjuan, Bastie Claire C., Tarabra, Elena, Gong-She Yang (490794), Claire C. Bastie (187271), Palacios Gustavo, Yingjuan Yang (490792), Irwin J. Kurland (177409), Claire C Bastie, Yingjuan Yang, Yang Gong-She, Yang, Gong-She, Irwin J Kurland, Vaitheesvaran, Bhavapriya, Palacios, Gustavo, Pessin Jeffrey E., Jeffrey E. Pessin (187274), Vaitheesvaran Bhavapriya, Yang, Yingjuan, Bhavapriya Vaitheesvaran (177385), Elena Tarabra (490793), Tarabra Elena, Bhavapriya Vaitheesvaran, Gustavo Palacios (67191), Kurland Irwin J., Gong-She Yang, Pessin, Jeffrey E.   +31 more
core   +2 more sources

Network pharmacology-based investigation of the pharmacological mechanisms of diosgenin in nonalcoholic steatohepatitis

Scientific Reports
The prevalence of nonalcoholic steatohepatitis (NASH) is rising annually, posing health and economic challenges, with limited treatments available.
Peiyuan Gu, Juan Chen, Jingxin Xin, Huiqi Chen, Ran Zhang, Dan Chen, Yuhan Zhang, Shanshan Shao   +7 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Stimulation of glucose utilization in 3T3 adipocytes and rat diaphragm in vitro by the sulphonylureas, glimepiride and glibenclamide, is correlated with modulations of the cAMP regulatory cascade [PDF]

, 1994
The long-term hypoglycemic activity of sulphonylurea drugs has been attributed, in part at least, to the stimulation of glucose utilization in extra-pancreatic tissues. The novel sulphonylurea, glimepiride, gives rise to a longer lasting reduction in the
Wetekam, Eva-Marlen, Wied, Susanne, Pünter, Jürgen, Unkelbach, Angelika, Crecelius, Anna, Müller, Günter   +5 more
core   +1 more source

Autoimmune thyroid disease and ovarian hypofunction: a review of literature

Journal of Ovarian Research
Thyroid hormones(THs) are essential for the proper functioning of the ovaries, and multiple studies have shown that thyroid abnormalities, especially during adolescence and reproductive age, can lead to lifelong ovarian dysfunction.
Ru Wang, Youyuan Lv, Tao Dou, Qian Yang, Chunxiao Yu, Qingbo Guan   +5 more
doaj   +1 more source