Results 51 to 60 of about 853,847 (318)

Stimulation of glucose utilization in 3T3 adipocytes and rat diaphragm in vitro by the sulphonylureas, glimepiride and glibenclamide, is correlated with modulations of the cAMP regulatory cascade [PDF]

, 1994
The long-term hypoglycemic activity of sulphonylurea drugs has been attributed, in part at least, to the stimulation of glucose utilization in extra-pancreatic tissues. The novel sulphonylurea, glimepiride, gives rise to a longer lasting reduction in the
Wetekam, Eva-Marlen, Wied, Susanne, Pünter, Jürgen, Unkelbach, Angelika, Crecelius, Anna, Müller, Günter   +5 more
core   +1 more source

Divergent impacts of estradiol/testosterone reduction on biological aging: optimal HRT window in females recommended

Biology of Sex Differences
Background The age-specific magnitude of the impact of hormones on aging and the role of hormone replacement therapy (HRT) remain unclear. Methods We used data from UK Biobank participants for our analysis.
Yicheng Ma, Junming Han, Qihang Li, Xiao Jiang, Yuan Li, Keke Zhang, Ling Gao   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Strategic locations of white matter hyperintensities associated with cognitive impairment across the cognitive spectrum among rural older adults: a population-based study

Alzheimer’s Research & Therapy
Background The location of white matter hyperintensities (WMH) is crucial for cognitive impairment. We sought to identify tract-based strategic locations of WMH that are associated with cognitive impairment across the cognitive spectrum from low ...
Chunyan Li, Jiafeng Wang, Ziwei Chen, Xiaodong Han, Cuicui Liu, Huisi Zhang, Jie Lu, Yifei Ren, Tao Gong, Yan Wang, Xiaoyu Wang, Qianqian Xie, Tingting Hou, Yongxiang Wang, Lin Cong, Grégoria Kalpouzos, Lin Song, Yifeng Du, Chengxuan Qiu   +18 more
doaj   +1 more source

Liver glucose metabolism in humans [PDF]

Bioscience Reports, 2016
Information about normal hepatic glucose metabolism may help to understand pathogenic mechanisms underlying obesity and diabetes mellitus. In addition, liver glucose metabolism is involved in glycosylation reactions and connected with fatty acid metabolism.
Adeva-Andany, María M., Pérez-Felpete, Noemi, Fernández-Fernández, Carlos, Donapetry-García, Cristóbal, Pazos-García, Cristina   +4 more
openaire   +2 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Effect of different NADH oxidase levels on glucose metabolism by Lactococus lactis : kinetics of intracellular metabolite pools determined by in vivo nuclear magnetic resonance

, 2002
Three isogenic strains of Lactococcus lactis with different levels of H2O-forming NADH oxidase activity were used to study the effect of oxygen on glucose metabolism: the parent strain L.
Vos, W.M., de, Kleerebezem, M., Hugenholtz, J., Ramos, A., Santos, H., Neves, A.R., Costa, H., Swam, I.I., van   +7 more
core   +1 more source

Proteomics identifies complement protein signatures in patients with primary biliary cholangitis

European Journal of Medical Research
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease lacking reliable biomarkers for diagnosis or prognosis. To identify plasma complement biomarkers that improve diagnosis and prognosis of PBC.
Xiaolin Ma, Hang Dong, Junming Han, Ming Han, Teng Zhang, Meng Zhou, Xiude Fan, Luna Liu, Zhen Wang   +8 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Compartmentation of glycogen metabolism revealed from 13C isotopologue distributions [PDF]

, 2011
Background: Stable isotope tracers are used to assess metabolic flux profiles in living cells. The existing methods of measurement average out the isotopic isomer distribution in metabolites throughout the cell, whereas the knowledge of compartmental ...
Marin, Silvia, Loranne Agius, Selivanov, Vitaly, Marta Cascante, Roca Elias, Josep, Oresic, Matej, Cascante i Serratosa, Marta, Cascante, Marta, Igor Marin de Mas, Josep Roca, Marín Martínez, Silvia, Selivanov, Vitaly A., de Mas, Igor Marin, Silvia Marin, Agius, Loranne, Vitaly A Selivanov, Matej Orešič, Marín de Mas, Igor Bartolomé, Roca, Josep   +18 more
core   +1 more source