Results 31 to 40 of about 853,847 (318)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Metabolic Fluxes and Stoichiometry of Glucose Metabolism [PDF]

Biophysical Journal, 2008
I would like to comment on a recent article by Bertram et al. titled “Interaction of Glycolysis and Mitochondrial Respiration in Metabolic Oscillations of Pancreatic Islets”(1xInteraction of glycolysis and mitochondrial respiration in metabolic oscillations of pancreatic islets.
openaire   +2 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Alteration of de novo glucose production contributes to fasting hypoglycaemia in fyn deficient mice [PDF]

, 2013
Previous studies have demonstrated that glucose disposal is increased in the Fyn knockout (FynKO) mice due to increased insulin sensitivity. FynKO mice also display fasting hypoglycaemia despite decreased insulin levels, which suggested that hepatic ...
Bastie, Claire C., Kurland, Irwin J., Elena Tarabra, Gustavo Palacios, Jeffrey E Pessin, Yang Yingjuan, Bastie Claire C., Tarabra, Elena, Gong-She Yang (490794), Claire C. Bastie (187271), Palacios Gustavo, Yingjuan Yang (490792), Irwin J. Kurland (177409), Claire C Bastie, Yingjuan Yang, Yang Gong-She, Yang, Gong-She, Irwin J Kurland, Vaitheesvaran, Bhavapriya, Palacios, Gustavo, Pessin Jeffrey E., Jeffrey E. Pessin (187274), Vaitheesvaran Bhavapriya, Yang, Yingjuan, Bhavapriya Vaitheesvaran (177385), Elena Tarabra (490793), Tarabra Elena, Bhavapriya Vaitheesvaran, Gustavo Palacios (67191), Kurland Irwin J., Gong-She Yang, Pessin, Jeffrey E.   +31 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease. [PDF]

, 2014
Unlike most other cell types, neurons preferentially metabolize glucose via the pentose phosphate pathway (PPP) to maintain their antioxidant status. Inhibiting the PPP in neuronal cell models causes cell death.
Allen, GF, Holton, Janice L., Dunn, L, Pope, Simon, Li, A, Lees, A, Li, Abi, Ling, Helen, Lees, Andrew, Allen, George FG., Heales, SJ, Duberley, KE, Hargreaves, Iain P., Dunn, Laura, Allen, George F. G., Mamais, A, Mamais, Adamantios, Bandopadhyay, Rina, Hargreaves, IP, Holton, JL, Bandopadhyay, R, Ling, H, Duberley, Kate E., Pope, S, Heales, Simon J.   +24 more
core   +1 more source

Associations of insulin resistance-related indices with incident carotid plaques by cardiovascular risk profiles: a prospective cohort study

Lipids in Health and Disease
Background Evidence has linked insulin resistance (IR) with atherosclerotic disorders, but their relationship by different cardiovascular risk profiles remains indistinct.
Peiyao Liu, Hailing Wang, Xu Han, Ruichun Jin, Jiao Li, Shiqing Song, Weihua Zhao, Yanan Song, Yongli Pan, Xiaotong Ma, Xiang Wang, Chengxuan Qiu, Qinjian Sun   +12 more
doaj   +1 more source

High-throughput sequencing reveals Jatrorrhizine inhibits colorectal cancer growth by ferroptosis-related genes

BMC Medical Genomics, 2023
Background Colorectal cancer is a malignant tumor that poses a serious threat to human health. The main objective of this study is to investigate the mechanism by which Jatrorrhizine (JAT), a root extract from Stephania Epigaea Lo, exerts its anticancer ...
Lingyu Huang, Yu Sha, Wenken Liang, Chune Mo, Chunhong Li, Yecheng Deng, Weiwei Gong, Xianliang Hou, Minglin Ou   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source