Results 21 to 30 of about 2,165,842 (306)

Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity [PDF]

, 2011
The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) enhances oxidative metabolism in skeletal muscle. Excessive lipid oxidation and electron transport chain activity can, however, lead to the accumulation of harmful metabolites and ...
Troxler, H., Christoph Handschin, Serge Summermatter, Summermatter, S., Summermatter, S, Handschin, C., Santos, G., Gesa Santos, Santos, G, Handschin, C, Heinz Troxler, Troxler, H   +11 more
core   +1 more source

Crossroads between drug and energy metabolism : role of constitutive androstane receptor and AMP-activated kinase [PDF]

, 2010
Phenobarbital (PB) is a prototype inducer of genes encoding drug metabolizing enzymes including the cytochromes P450 (CYPs). Additionally, phenobarbital was found to repress genes that encode enzymes involved in gluconeogenesis such as ...
Harach, Taoufiq
core   +1 more source

Carbohydrate and lipid metabolism in insulin resistant states and the development of in vivo magnetic resonance spectroscopic techniques for the analysis of gluconeogenesis and glycogen synthesis [PDF]

, 1995
PhDThis thesis will provide new information on carbohydrate and lipid metabolic control in various related physiological states both in vitro and in vivo in the rat model.
Changani, K.K., Changani, Kishore Kumar
core   +4 more sources

Abnormal whole-brain voxelwise structure-function coupling and its association with cognitive dysfunction in patients with different cerebral small vessel disease burdens

Frontiers in Aging Neuroscience, 2023
Cerebral small vessel disease (CSVD) is a universal neurological disorder in older adults that occurs in connection with cognitive dysfunction and is a chief risk factor for dementia and stroke.
Xinyue Zhang, Changhu Liang, Na Wang, Yuanyuan Wang, Yian Gao, Chaofan Sui, Haotian Xin, Mengmeng Feng, Lingfei Guo, Hongwei Wen   +9 more
doaj   +1 more source

The level of mendione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion

, 2012
Pancreatic β-cells release insulin in response to elevation of glucose from basal (4–7 mM) to stimulatory (8–16 mM) levels. Metabolism of glucose by the β-cell results in the production of low levels of reactive oxygen intermediates (ROI), such as ...
Womack, Trayce, Gray, Joshua P., Joshua P. Gray, Peter J.S. Smith, Smith, Peter J. S., Meridith Palo, Heart, Emma, Trayce Womack, Emma Heart   +8 more
core   +1 more source

Circulating free fatty acids, insulin, and glucose during chemical stimulation of hypothalamus in rats [PDF]

, 1984
The aim of this study was to investigate plasma free fatty acids (FFA), insulin, and blood glucose during chemical stimulation of the lateral and ventromedial hypothalamic areas (LHA and VMH) in rats.
Steffens, A.B., P. G. Luiten, van der Gugten, J., Steffens, A.B.,, Gugten, J. van der,, J. van der Gugten, Luiten, P.G.M., A. B. Steffens, Luiten, P.G.M.,, Damsma, G., G. Damsma, Damsma, G.,   +11 more
core   +1 more source

Pre-exercise galactose and glucose ingestion on fuel utilization during exercise [PDF]

, 2012
Purpose: This study determined the effect of ingesting galactose and glucose 30 minutes prior to exercise on exogenous and endogenous fuel utilization during exercise.
Cooke, C.B., Preston, T., King, R.F.G.J., King, RF, King, Roderick F.G.J., Cooke, CB, O'Hara, J.P., Cooke, Carlton B., Preston, T, Carroll, S, Preston, Thomas, Morrison, D.J., O'Hara, J, Carroll, S., Carroll, Sean, Morrison, Douglas J., Cooke, Carlton, King, Roderick F G J, Morrison, DJ, O'Hara, John P.   +19 more
core   +1 more source

Serum Lipidome and Metabolome Alterations in Obese Patients Undergoing Targeted Diet and Exercise Interventions: A Marker of Thyroid Function Recovery?

International Journal of Endocrinology
Trial Registration: Chinese Registry of Clinical Trials ...
Changxu Zhou, Heng Wang, Qingtao Yu, Jingxin Xin, Huiqi Chen, Ran Zhang, Qingbo Guan, Shanshan Shao   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source