Results 1 to 10 of about 853,847 (318)

Overexpression of SCAP inhibits autophagy and promotes lipid accumulation in vascular smooth muscle cells

Di-san junyi daxue xuebao, 2022
Objective To determine the effect of sterol regulatory element binding proteins cleavage activating protein (SCAP) on foam cell formation in vascular smooth muscle cells (VSMCs). Methods LV-SCAP were constructed with LV-SCAP, and LV-Control group served
RAO Yuhan, LI Danyang, HOU Xiaoli, YAO Yincheng, SU Yu   +4 more
doaj   +1 more source

Clinical Characteristics of Inpatients With New-Onset Diabetes Mellitus in Eastern China: Based on Novel Clustering Analysis

Frontiers in Endocrinology, 2022
IntroductionThis study aimed to explore the novel classification of inpatients with new-onset diabetes in Eastern China by the cluster-based classification method and compare the clinical characteristics among the different subgroups.MethodsA total of ...
Xueke Song, Xueke Song, Yingqi Lv, Yingqi Lv, Nan Huang, Nan Huang, Jinfang Sun, Ting Yang, Ting Yang, Xiaoyuan Wang, Xiaoyuan Wang, Jianan Zhang, Jianan Zhang, Ziwei Zhou, Ziwei Zhou, Huihua Gao, Jie Li, Wei Zhang, Han Yin, Han Yin, Qiong Wei, Qiong Wei, Kun Wang, Ling Li, Ling Li   +24 more
doaj   +1 more source

Glucose metabolism in bone [PDF]

Bone, 2018
The adult human skeleton is a multifunctional organ undergoing constant remodeling through the opposing activities of the bone-resorbing osteoclast and the bone-forming osteoblast. The exquisite balance between bone resorption and bone formation is responsible for bone homeostasis in healthy adults.
Courtney M. Karner, Fanxin Long
openaire   +2 more sources

CCR5 as a prognostic biomarker correlated with immune infiltrates in head and neck squamous cell carcinoma by bioinformatic study

Hereditas, 2022
Background C-C chemokine receptor 5 (CCR5) has recently been recognized as an underlying therapeutic target for various malignancies. However, the association of CCR5 with prognosis in the head and neck squamous cell carcinoma (HNSC) patients and tumor ...
Chunhong Li, Shanlin Chen, Chuanyu Liu, Chune Mo, Weiwei Gong, Jiahua Hu, Min He, Lei Xie, Xianliang Hou, Jianhong Tang, Minglin Ou   +10 more
doaj   +1 more source

Glucose metabolism and hyperglycemia [PDF]

The American Journal of Clinical Nutrition, 2008
Islet dysfunction and peripheral insulin resistance are both present in type 2 diabetes and are both necessary for the development of hyperglycemia. In both type 1 and type 2 diabetes, large, prospective clinical studies have shown a strong relation between time-averaged mean values of glycemia, measured as glycated hemoglobin (HbA1c), and vascular ...
GIUGLIANO, Dario, CERIELLO A, ESPOSITO, Katherine   +2 more
openaire   +4 more sources

The association of soluble cluster of differentiation 36 with metabolic diseases: A potential biomarker and therapeutic target

Pediatric Discovery, 2023
A cluster of differentiation 36 (CD36), also known as fatty acid translocase, plays an important role in developing and progressing metabolic diseases. Soluble CD36 (sCD36), a circulating form of CD36, is identified in human plasma.
Yun Li, Yaxi Chen, Xiong Z. Ruan
doaj   +1 more source

FAM65A as a novel prognostic biomarker in human tumors reveal by a pan-cancer analysis

Discover Oncology, 2021
Background Family with sequence similarity 65 member A (FAM65A), also known as RIPOR1, is differentially expressed between human tumor and non-tumor tissues in kinds of cancers.
Wenken Liang, Chune Mo, Jianfen Wei, Wei Chen, Weiwei Gong, Jianling Shi, Xianliang Hou, Chunhong Li, Yecheng Deng, Minglin Ou   +9 more
doaj   +1 more source

Neonatal overfeeding in mice aggravates the development of methionine and choline-deficient diet-induced steatohepatitis in adulthood

Genes and Diseases, 2019
Overfeeding in early life is associated with obesity and insulin resistance in adulthood. In the present study, a well-characterized mouse model was used to investigate whether neonatal overfeeding increases susceptibility to the development of non ...
Juan Du, Xuemei Cao, Junlin Diao, Qijuan Zhang, Chuan Peng, Jibin Li, Xiaoqiu Xiao   +6 more
doaj   +1 more source

Microarray and bioinformatic analysis reveal the parental genes of m6A modified circRNAs as novel prognostic signatures in colorectal cancer

Frontiers in Oncology, 2022
BackgroundAccumulating evidences have revealed that the abnormal N6-methyladenosine (m6A) modification is closely associated with the occurrence, development, progression and prognosis of cancer.
Wenken Liang, Wenken Liang, Liyuan Deng, Chune Mo, Wei Chen, Yu Sha, Jianling Shi, Xianliang Hou, Yuping Zhang, Min Yang, Minglin Ou   +10 more
doaj   +1 more source

Glucose Metabolism and Glucose Transporters in Breast Cancer [PDF]

Frontiers in Cell and Developmental Biology, 2021
Breast cancer is the most common malignancy in women worldwide and is associated with high mortality rates despite the continuously advancing treatment strategies. Glucose is essential for cancer cell metabolism owing to the Warburg effect. During the process of glucose metabolism, various glycolytic metabolites, such as serine and glycine metabolites,
Eunah Shin, Ja Seung Koo
openaire   +4 more sources