Results 131 to 140 of about 853,847 (318)

Differential impact of N-Methyl-D-Aspartate Receptor antagonists on genes involved in synaptic plasticity and neural glucose metabolism: implication for psychosis.

, 2011
Background: NMDA-R-hypofunction (NRH) is considered one of the putative molecular mechanism involved in psychosis. Several studies show that an imbalance of dopamine–glutamate transmission has a key role in psychosis pathophysiology.
Sarappa, Chiara
core  

An oral nanocombinatorial agent exhibits pleiotropic improvement in diabetic nephropathy via modulation of the SCAP/SREBPs pathway

Journal of Nanobiotechnology
The multifaceted pathogenesis and multi-cellular involvement of diabetic nephropathy (DN) stand in stark contrast to the inadequacy of conventional single-target therapeutic strategies.
Yu Su, Haobo Wen, Ke Hu, Cuiping Wen, Ping Wang, Lulu Zhao, Gang Zou, Wei Jiang, Yaxi Chen, Yunfei Zhao, Qiu Li   +10 more
doaj   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Metabolic dysregulation and biological age acceleration in Hashimoto’s thyroiditis: a cross-sectional study based on clinical biomarker aging indices and metabolomics

Frontiers in Endocrinology
BackgroundHashimoto’s thyroiditis (HT) is a common autoimmune thyroid disease characterized by thyroid autoantibody positivity, chronic lymphocytic inflammation, and varying degrees of thyroid dysfunction.
Xinyu Zhao, QunHao Li, Tao Luo, Wenxuan Fang, Qian Liu, Hao Li, Jie Su, Xiao Jiang, Jialan Yu   +8 more
doaj   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

Systematic Evaluation of the Impact of a Wide Range of Dietary Habits on Myocardial Infarction: A Two‐Sample Mendelian Randomization Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Myocardial infarction is a cardiovascular disease that significantly contributes to global morbidity and disability. Given the significant role of diet in the pathogenesis and prevention of cardiovascular diseases, this study rigorously ...
Qian Yang, Man Li, Pengcheng Chen, Naixin Dou, Mei Liu, Peng Lu, Chunxiao Yu   +6 more
doaj   +1 more source

Glucose metabolism in acromegaly [PDF]

Diabetologia, 1987
M, Vranic, S, Efendic
openaire   +2 more sources

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Tracking Spatiotemporal Extracellular Matrix Evolution and Tissue Fusion in 3D Microtissues via Click Chemistry‐Based Metabolic Labelling

Advanced Healthcare Materials, EarlyView.
Metabolic labeling of nascent proteins in 3D microtissue spheroids provides a powerful analytical approach for large‐scale tissue engineering. Incorporation of non‐canonical amino acids with fluorescent tagging enables spatiotemporal investigation of extracellular matrix deposition and its evolution during multicellular tissue development and fusion ...
Theresa Koenig, F. Max Yavitt, Laura Veenendaal, Tim B. F. Woodfield   +3 more
wiley   +1 more source

Adaptable Covalent Organic Framework‐Hydrogel Microneedles for Glucose‐Responsive Isoliquiritigenin Delivery in Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
We develop a covalent organic framework‐loaded Traditional Chinese Medicine monomer nanodrug delivery system (ISL@bCOF) via boron‐oxygen bonds, a smart response to glucose for delivering AI‐driven isoliquiritigenin (ISL) targeting ZBP1. This dynamic release mechanism, combined with transdermal delivery technology via potent microneedles, can modulate ...
Menghan Zhou, Zongjie Hu, Xiuwen Li, Huaman Geng, Yang Liu, Yajie Wang, Yunshu Yang, Guangdong Zhou, Yujie Hua, Di Wang   +9 more
wiley   +1 more source