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Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

Cardiovascular autonomic dysfunction is linked with arterial stiffness across glucose metabolism: the Maastricht study. [PDF]

BMJ Open Diabetes Res Care
Schaarup JR, Bjerg L, Hansen CS, Andersen ST, van Greevenbroek MM, Schram MT, De Galan BE, Stehouwer C, Witte DR.   +8 more
europepmc   +1 more source

Triglycerides, Glucose Metabolism, and Type 2 Diabetes. [PDF]

Int J Mol Sci
Wang Y.
europepmc   +1 more source

The mechanisms in glucose metabolism of aging hippocampus. [PDF]

Ibrain
He R, Zhao F, Yang Z, Wang T, Zhang Y, Quan J, Zhu G.   +6 more
europepmc   +1 more source

ETS Variant Transcription Factor 6 Promotes Glucose Metabolism Reprogramming in HCC. [PDF]

J Cell Mol Med
Guo C, Xie L, Yin H, Yi L, Jin L, Liu X, Zhang Q, Li Z, Liu S, Sun MZ.   +9 more
europepmc   +1 more source

Regulatory Effects of Pumpkin Seed Extract on Glucose Metabolism and Insulin Signaling in Diabetic Models. [PDF]

ACS Omega
Lin YC, Hsu PK, Pan MH.
europepmc   +1 more source

Transcriptomic responses and molecular mechanisms of glucagon-regulated glucose metabolism in Japanese flounder (<i>Paralichthys olivaceus</i>). [PDF]

Front Physiol
Zhang T, Wang H, Xiao T, Yang M, Zhang W.   +4 more
europepmc   +1 more source

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Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism

Cell Metabolism, 2023
Isha Jain
exaly